Novel endogenous endoplasmic reticulum transmembrane protein SURF4 suppresses cell death by negatively regulating the STING-STAT6 axis inmyeloid leukemia

Dear Editor,Myeloid differentiation was shown to be associated with reduced leukemic cell burden and leukemia-initiating cells and improved survival[1].Reactive oxygen species(ROS)are associated with leukemia and can induce endoplasmic reticulum(ER)stress.ER stress induces several mechanisms,including cell death[2].The stimulator of interferon genes(STING)is also an ER transmembrane protein and promotes anti-tumor immunity by linking innate and adaptive immunity[3].Signal transducer and activator of transcription 6(STAT6)plays a prominent role in adaptive immunity by transducing signals fromextracellular cytokines and inducing apoptosis in cancer cells[4].

纯铜高压扭转压缩阶段塑性变形的实验及有限元分析(英文)

利用实验及有限元分析等手段,对纯铜高压扭转压缩阶段的塑性变形行为、硬度及显微组织分布进行了研究,结果表明,试样经压缩后,其硬度分布极为不均匀,边缘硬度高,轴心部位硬度低,而中间部位硬度变化较为平缓。模拟结果显示,试样在压缩过程中的应力应变呈不均匀变化,由此引起试样各部位显微组织及晶粒变形不均匀。进一步研究表明,试样与模具间的摩擦对于压缩阶段试样变形具有重要影响。