Polyacrylamide gel migration after injection for breast augmentation:A case report

Polyacrylamide hydrogel(PAAG)was once considered a safe,reliable,and compatible injected filler and was widely used in breast augmentation,rhinoplasty,and other cosmetic surgeries.However,numerous complications,such as implant migration,have been observed after PAAG injections.Herein,we report a rare case of distant implant migration after PAAG injection for breast augmentation in which the material became displaced along the abdominal wall to the perineum and pelvic extraperitoneal space.After a well-prepared preoperative evaluation involving magnetic resonance imaging(MRI)and computed tomography(CT)examinations and threedimensional hologram,debridement surgery was performed to remove the injected material.After the operation,the patient was followed up for two years and was not scheduled for a second operation.Postoperative complications of breast augmentation after PAAG injection,especially gel migration,still affect thousands of patients.Once material migration occurs,surgical removal becomes difficult.Early diagnosis and treatment are recommended.

Discussion on the mechanism of Salvia miltiorrhiza in treating pathological scars based on network pharmacology

In the present study, we aimed to explore the mechanism of Salvia miltiorrhiza in the treatment of pathological scars(PS) by network pharmacology. The active ingredients and drug targets of Salvia miltiorrhiza were screened out through TCMSP database, the disease targets of PS in Gene Cards database were obtained, and Venn diagram analysis on drug targets and disease targets was performed, and the intersection was used as the target of Salvia miltiorrhiza for the treatment of PS. Cytoscape software was used to construct a drug-ingredient-target-disease network diagram. A protein-protein interaction network was constructed through String website, its key protein modules and hub genes were screened with Cytoscape software, and GO and KEGG enrichment analyses were performed in DAVID database. Fifty-nine active ingredients, 138 drug targets, and 90 targets of Salvia miltiorrhiza for the treatment of PS were screened out. Core ingredients, such as luteolin and tanshinone IIA, were obtained. The hub genes, such as VEGFA, TP53, JUN, STAT3, AKT1, MAPK1, and PTGS2, and signaling pathways, such as HIF-1, TNF, MAPK, PI3 K-Akt, and Jak-STAT, were screened out. Salvia miltiorrhiza might improve PS hypoxia, inflammation, and balance of proliferation and apoptosis of fibroblasts by regulating HIF-1, TNF, MAPK, PI3 K-Akt, and Jak-STAT signaling pathways. Moreover, it had the characteristics of multiple centers, multiple targets, and multiple pathways.

Synthesis and properties of novel organogelators functionalized with 5-iodo-1,2,3-triazole and azobenzene groups

Two series of 5-iodo-l,2,3-triazole derivatives containing azobenzene group（s） were synthesized and their gelling properties were tested. Those containing two azobenzene groups （B series） have better gelation performance than those containing one azobenzene group （A series）. The microstructure of organogels and the driving force of gelation were investigated by scanning electron microscopy and 1H NMR, respectively. It was found that π-π stacking, van der Waals interaction, and dipole-dipole interaction were the main forces of gelation. All the tested organogels are photoresponsive and those from B series are smarter than that from A series. Henry δp-δb diagrams of compounds A1, A2, and B2 were constructed on the basis of their gelation performance and the Hansen solubility parameters of related solvents. The constructed Henry δp-δh diagrams can be used to estimate the behavior of three compounds in any untested solvent.

High-Resolution Projections of Mean and Extreme Precipitation over China by Two Regional Climate Models

In this study, we employ two regional climate models(RCMs or RegCMs), which are RegCM4 and PRECIS(Providing Regional Climates for Impact Studies), with a horizontal grid spacing of 25 km, to simulate the precipitation dynamics across China for the baseline climate of 1981–2010 and two future climates of 2031–2060 and 2061–2090. The global climate model(GCM)—Hadley Centre Global Environment Model version 2-Earth Systems(HadGEM2-ES) is used to drive the two RCMs. The results of baseline simulations show that the two RCMs can correct the obvious underestimation of light rain below 5 mm day^-1 and the overestimation of precipitation above 5 mm day^-1 in Northwest China and the Qinghai–Tibetan Plateau, as being produced by the driving GCM. While PRECIS outperforms RegCM4 in simulating annual precipitation and wet days in several sub-regions of Northwest China, its underperformance shows up in eastern China. For extreme precipitation, the two RCMs provide a more accurate simulation of continuous wet days(CWD) with reduced biases and more realistic spatial patterns compared to their driving GCM. For other extreme precipitation indices, the RCM simulations show limited benefit except for an improved performance in some localized regions. The future projections of the two RCMs show an increase in the annual precipitation amount and the intensity of extreme precipitation events in most regions. Most areas of Southeast China will experience fewer number of wet days, especially in summer, but more precipitation per wet day(≥ 30 mm day^-1). By contrast, number of wet days will increase in the Qinghai–Tibetan Plateau and some areas of northern China. The increase in both the maximum precipitation for five consecutive days and the regional extreme precipitation will lead to a higher risk of increased flooding. The findings of this study can facilitate the efforts of climate service institutions and government agencies to improve climate services and to make climate-smart decisions.