Chemotherapy is one of the conventional treatments for cancer in clinical practice.However,poor delivery efficiency,systemic toxicity,and the lack of pharmacokinetic monitoring during treatment are the critical limita...Chemotherapy is one of the conventional treatments for cancer in clinical practice.However,poor delivery efficiency,systemic toxicity,and the lack of pharmacokinetic monitoring during treatment are the critical limitations of current chemotherapy.Herein,we reported a brand-new antitumor drug delivery strategy that harnesses an optical fiber endoscopically therapeutic probe.The fiber probe carries photosensitizers in the fiber core and antitumor agents on the fiber surface mediated by a temperature-responsive hydrogel film,giving rise to an activable photothermalchemotherapy that orchestrates the localized hyperthermia and thermal-stimuli drug release to the tumor lesion.Furthermore,the dynamical drug release and in-situ temperature can be real-time supervised through the built-in fiber sensors,including the reflective Mach–Zehnder interferometer and fiber Bragg grating,to visualize the therapy process and thus improve the safety of treatment.Compared with conventional methods,the fiber-optic drug delivery can adequately take advantage of the chemotherapeutics through collaboratively recruiting the photoheating-mediated enhanced permeability and the hydrogel particle-assisted high drug retention,shedding new light on a“central-toperipheral”drug pervasion and retention mechanism to destroy tumors completely.The fiber-optic chemotherapy strategy incorporates precise drug delivery,accurate controllability of drug release,high drug permeability and retention in tumor,low off-target rate,and real-time drug release and temperature feedback,performing a straightforward and precise photothermal-chemotherapy pathway.More than that,the proposed strategy holds tremendous promise to provide a revolutionized on-demand drug delivery platform for the highly efficient evaluation and screening of antitumor pharmaceuticals.展开更多
Cancer has been one of the most serious diseases,resulting in more than 10 million deaths every year.Fiber-optic sensors have great potential for diagnosing and treating cancer due to their flexibility,precise positio...Cancer has been one of the most serious diseases,resulting in more than 10 million deaths every year.Fiber-optic sensors have great potential for diagnosing and treating cancer due to their flexibility,precise positioning,real-time monitoring,and minimally invasive characteristics.Compared to traditional central laboratory examination,fiber-optic biosensors can provide high sensitivity,miniaturization,and versatility,which feature the point-of-care diagnostic capability.Herein,we focus on recent advances in fiber-optic biosensors for cancer theranostics.It is primarily concerned with advancements in the design of various fiber sensing approaches,fiber cancer sensing,and therapy sensors.With fiber-optic biosensors,cancer marker detection,cancerous cell differentiation,ex vivo tumor model validation,and in vivo tumor detection can be achieved.And the medical fiber also can be used to provide photothermal therapy,photodynamic therapy,and combination therapy for solid tumors.Additionally,cancer sensing and therapy can be integrated into the fiber,which demonstrates the multiplexing capabilities of fiber-optic biosensors.Lastly,we systematically summarize the fiber biosensor applications from in vitro to in vivo,and conclude with the challenges in development and prospects.展开更多
Recent years have witnessed a rapid spread of multi-modality microblogs like Twitter and Sina Weibo composed of image, text and emoticon. Visual sentiment prediction of such microblog based social media has recently a...Recent years have witnessed a rapid spread of multi-modality microblogs like Twitter and Sina Weibo composed of image, text and emoticon. Visual sentiment prediction of such microblog based social media has recently attracted ever-increasing research focus with broad application prospect. In this paper, we give a systematic review of the recent advances and cutting-edge techniques for visual senti- ment analysis. To this end, in this paper we review the most recent works in this topic, in which detailed comparison as well as experimental evaluation are given over the cuttingedge methods. We further reveal and discuss the future trends and potential directions for visual sentiment prediction.展开更多
基金supported by the National Natural Science Foundation of China(62335010)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2019BT02X105)Fundamental Research Funds for the Central Universities(21623203).
文摘Chemotherapy is one of the conventional treatments for cancer in clinical practice.However,poor delivery efficiency,systemic toxicity,and the lack of pharmacokinetic monitoring during treatment are the critical limitations of current chemotherapy.Herein,we reported a brand-new antitumor drug delivery strategy that harnesses an optical fiber endoscopically therapeutic probe.The fiber probe carries photosensitizers in the fiber core and antitumor agents on the fiber surface mediated by a temperature-responsive hydrogel film,giving rise to an activable photothermalchemotherapy that orchestrates the localized hyperthermia and thermal-stimuli drug release to the tumor lesion.Furthermore,the dynamical drug release and in-situ temperature can be real-time supervised through the built-in fiber sensors,including the reflective Mach–Zehnder interferometer and fiber Bragg grating,to visualize the therapy process and thus improve the safety of treatment.Compared with conventional methods,the fiber-optic drug delivery can adequately take advantage of the chemotherapeutics through collaboratively recruiting the photoheating-mediated enhanced permeability and the hydrogel particle-assisted high drug retention,shedding new light on a“central-toperipheral”drug pervasion and retention mechanism to destroy tumors completely.The fiber-optic chemotherapy strategy incorporates precise drug delivery,accurate controllability of drug release,high drug permeability and retention in tumor,low off-target rate,and real-time drug release and temperature feedback,performing a straightforward and precise photothermal-chemotherapy pathway.More than that,the proposed strategy holds tremendous promise to provide a revolutionized on-demand drug delivery platform for the highly efficient evaluation and screening of antitumor pharmaceuticals.
基金supported by the National Natural Science Foundation of China(Grant No.62335010)Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(Grant No.2019BT02X105)Fundamental Research Funds for the Central Universities(Grant No.21623203).
文摘Cancer has been one of the most serious diseases,resulting in more than 10 million deaths every year.Fiber-optic sensors have great potential for diagnosing and treating cancer due to their flexibility,precise positioning,real-time monitoring,and minimally invasive characteristics.Compared to traditional central laboratory examination,fiber-optic biosensors can provide high sensitivity,miniaturization,and versatility,which feature the point-of-care diagnostic capability.Herein,we focus on recent advances in fiber-optic biosensors for cancer theranostics.It is primarily concerned with advancements in the design of various fiber sensing approaches,fiber cancer sensing,and therapy sensors.With fiber-optic biosensors,cancer marker detection,cancerous cell differentiation,ex vivo tumor model validation,and in vivo tumor detection can be achieved.And the medical fiber also can be used to provide photothermal therapy,photodynamic therapy,and combination therapy for solid tumors.Additionally,cancer sensing and therapy can be integrated into the fiber,which demonstrates the multiplexing capabilities of fiber-optic biosensors.Lastly,we systematically summarize the fiber biosensor applications from in vitro to in vivo,and conclude with the challenges in development and prospects.
文摘Recent years have witnessed a rapid spread of multi-modality microblogs like Twitter and Sina Weibo composed of image, text and emoticon. Visual sentiment prediction of such microblog based social media has recently attracted ever-increasing research focus with broad application prospect. In this paper, we give a systematic review of the recent advances and cutting-edge techniques for visual senti- ment analysis. To this end, in this paper we review the most recent works in this topic, in which detailed comparison as well as experimental evaluation are given over the cuttingedge methods. We further reveal and discuss the future trends and potential directions for visual sentiment prediction.
