A facile,efficient and substrate-selective oxidation of the primary amines with NaClO as oxidant catalyzed by β-cyclodextrin(β-CD)has been developed in water for the first time,and the behavior of β-cyclodextrin th...A facile,efficient and substrate-selective oxidation of the primary amines with NaClO as oxidant catalyzed by β-cyclodextrin(β-CD)has been developed in water for the first time,and the behavior of β-cyclodextrin that catalyzed the primary amines to nitriles in water was investigated.It was found that the primary amines which could form host-guest complexes with β-cyclodextrin were oxidized to nitriles with excellent yields at ambient temperature.The results show that β-cyclodextrin worked not only as a solubilizing agent but also as a catalyst in these reactions.展开更多
基金The authors thank the National Natural Science Foundation of China(Grant No.20776053)the Program for New Century Excellent Talents in University(NCET-06-740)for providing financial support for this project.
文摘A facile,efficient and substrate-selective oxidation of the primary amines with NaClO as oxidant catalyzed by β-cyclodextrin(β-CD)has been developed in water for the first time,and the behavior of β-cyclodextrin that catalyzed the primary amines to nitriles in water was investigated.It was found that the primary amines which could form host-guest complexes with β-cyclodextrin were oxidized to nitriles with excellent yields at ambient temperature.The results show that β-cyclodextrin worked not only as a solubilizing agent but also as a catalyst in these reactions.
