Under the background of“Internet plus”rapid development,the agricultural logistics industry should apply information technology to every link of the agricultural product logistics industry chain.By making full use o...Under the background of“Internet plus”rapid development,the agricultural logistics industry should apply information technology to every link of the agricultural product logistics industry chain.By making full use of the decision making module of the agricultural logistics information system,we can realize the full sharing of information and data resources,which makes the decision-making scheme of the agricultural logistics information system more optimized.In real economic society,the uncertainty and mismatch between the customer’s logistics service demand and the logistics service capability that the logistics service function provider can provide,that is,when the two information are asymmetric,how to use the third-party contract to coordinate the income and profit distribution of the two,to make the information system decision making more reasonable?This paper mainly studies the coordination scheme of agricultural logistics information system decision making under uncertain output and demand information by introducing the spot market.A joint coordination strategy based on revenue sharing and penalty feedback contracts proposes decentralized decision making based on game theory.Experiments show that the flexible ordering strategy proposed in this paper can reduce the logistics service supply chain’s uncertainty and significantly improve the logistics service supply chain’s overall income level through coordination contracts.展开更多
Background:Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer’s disease(AD),while how to initiate early cognitive stimulation is unclear.Given that the immature br...Background:Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer’s disease(AD),while how to initiate early cognitive stimulation is unclear.Given that the immature brain is more sensitive to environmental stimuli and that brain dynamics decrease with ageing,we reasoned that it would be effective to initiate cognitive stimulation against AD as early as the fetal period.Methods:After conception,maternal AD transgenic mice(3×Tg AD)were exposed to gestational environment enrichment(GEE)until the day of delivery.The cognitive capacity of the offspring was assessed by the Morris water maze and contextual fear-conditioning tests when the offspring were raised in a standard environment to 7 months of age.Western blotting,immunohistochemistry,real-time PCR,immunoprecipitation,chromatin immunoprecipitation(ChIP)assay,electrophysiology,Golgi staining,activity assays and sandwich ELISA were employed to gain insight into the mechanisms underlying the beneficial effects of GEE on embryos and 7–10-month-old adult offspring.Results:We found that GEE markedly preserved synaptic plasticity and memory capacity with amelioration of hallmark pathologies in 7–10-m-old AD offspring.The beneficial effects of GEE were accompanied by global histone hyperacetylation,including those at bdnf promoter-binding regions,with robust BDNF mRNA and protein expression in both embryo and progeny hippocampus.GEE increased insulin-like growth factor 1(IGF1)and activated its receptor(IGF1R),which phosphorylates Ca^(2+)/calmodulin-dependent kinase IV(CaMKIV)at tyrosine sites and triggers its nuclear translocation,subsequently upregulating histone acetyltransferase(HAT)and BDNF transcription.The upregulation of IGF1 mimicked the effects of GEE,while IGF1R or HAT inhibition during pregnancy abolished the GEE-induced CaMKIV-dependent histone hyperacetylation and BDNF upregulation.Conclusions:These findings suggest that activation of IGF1R/CaMKIV/HAT/BDNF signaling by gestational environment enrichment may serve as a promising strategy to delay AD progression.展开更多
Describing the correlation of a reservoir and earthquake slip remains a great challenge. Professor SHI Yaolin and his group at the Key Laboratory of Computational Geodynamics of the Chinese Academy of Sciences and the...Describing the correlation of a reservoir and earthquake slip remains a great challenge. Professor SHI Yaolin and his group at the Key Laboratory of Computational Geodynamics of the Chinese Academy of Sciences and the College of Science of the Graduate University of the Chinese Academy of Sciences are attempting to solve this problem. On the basis of the laboratory's parallel central processing unit (CPU)展开更多
基金The Agricultural Science and Technology Innovation Program(ASTIP-IAED-2021-08).
文摘Under the background of“Internet plus”rapid development,the agricultural logistics industry should apply information technology to every link of the agricultural product logistics industry chain.By making full use of the decision making module of the agricultural logistics information system,we can realize the full sharing of information and data resources,which makes the decision-making scheme of the agricultural logistics information system more optimized.In real economic society,the uncertainty and mismatch between the customer’s logistics service demand and the logistics service capability that the logistics service function provider can provide,that is,when the two information are asymmetric,how to use the third-party contract to coordinate the income and profit distribution of the two,to make the information system decision making more reasonable?This paper mainly studies the coordination scheme of agricultural logistics information system decision making under uncertain output and demand information by introducing the spot market.A joint coordination strategy based on revenue sharing and penalty feedback contracts proposes decentralized decision making based on game theory.Experiments show that the flexible ordering strategy proposed in this paper can reduce the logistics service supply chain’s uncertainty and significantly improve the logistics service supply chain’s overall income level through coordination contracts.
基金This work was supported in part by grants from the NSFC(91632305,91632111,31730035 and 81721005)by the Ministry of Science and Technology of China(2016YFC1305800).
文摘Background:Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer’s disease(AD),while how to initiate early cognitive stimulation is unclear.Given that the immature brain is more sensitive to environmental stimuli and that brain dynamics decrease with ageing,we reasoned that it would be effective to initiate cognitive stimulation against AD as early as the fetal period.Methods:After conception,maternal AD transgenic mice(3×Tg AD)were exposed to gestational environment enrichment(GEE)until the day of delivery.The cognitive capacity of the offspring was assessed by the Morris water maze and contextual fear-conditioning tests when the offspring were raised in a standard environment to 7 months of age.Western blotting,immunohistochemistry,real-time PCR,immunoprecipitation,chromatin immunoprecipitation(ChIP)assay,electrophysiology,Golgi staining,activity assays and sandwich ELISA were employed to gain insight into the mechanisms underlying the beneficial effects of GEE on embryos and 7–10-month-old adult offspring.Results:We found that GEE markedly preserved synaptic plasticity and memory capacity with amelioration of hallmark pathologies in 7–10-m-old AD offspring.The beneficial effects of GEE were accompanied by global histone hyperacetylation,including those at bdnf promoter-binding regions,with robust BDNF mRNA and protein expression in both embryo and progeny hippocampus.GEE increased insulin-like growth factor 1(IGF1)and activated its receptor(IGF1R),which phosphorylates Ca^(2+)/calmodulin-dependent kinase IV(CaMKIV)at tyrosine sites and triggers its nuclear translocation,subsequently upregulating histone acetyltransferase(HAT)and BDNF transcription.The upregulation of IGF1 mimicked the effects of GEE,while IGF1R or HAT inhibition during pregnancy abolished the GEE-induced CaMKIV-dependent histone hyperacetylation and BDNF upregulation.Conclusions:These findings suggest that activation of IGF1R/CaMKIV/HAT/BDNF signaling by gestational environment enrichment may serve as a promising strategy to delay AD progression.
文摘Describing the correlation of a reservoir and earthquake slip remains a great challenge. Professor SHI Yaolin and his group at the Key Laboratory of Computational Geodynamics of the Chinese Academy of Sciences and the College of Science of the Graduate University of the Chinese Academy of Sciences are attempting to solve this problem. On the basis of the laboratory's parallel central processing unit (CPU)
