Tribovoltaic nanogenerators(TVNGs)have the characteristics of high current density,low matched impedance and continuous output,which is expected to solve the problem of power supply for small electronic devices.Howeve...Tribovoltaic nanogenerators(TVNGs)have the characteristics of high current density,low matched impedance and continuous output,which is expected to solve the problem of power supply for small electronic devices.However,wear occurrence in friction interface will seriously reduce the performance of TVNGs as well as lifetime.Here,we employ MXene solution as lubricate to improve output current density and lifetime of TVNG simultaneously,where a high value of 754 mA m^(-2)accompanied with a record durability of 90,000 cycles were achieved.By comparing multiple liquid lubricates with different polarity,we show that conductive polar liquid with MXene as additive plays a crucial role in enhancing the electrical output performance and durability of TVNG.Moreover,the universality of MXene solution is well demonstrated in various TVNGs with Cu and P-type Si,and Cu and N-GaAs as material pairs.This work may guide and accelerates the practical application of TVNG in future.展开更多
The major earthquakes often trigger unrest of surrounding volcanic magma chambers.In recent years,three major earthquakes occurred around the Changbaishan volcano,but it was unclear whether these earthquakes triggered...The major earthquakes often trigger unrest of surrounding volcanic magma chambers.In recent years,three major earthquakes occurred around the Changbaishan volcano,but it was unclear whether these earthquakes triggered the unrest of the magma chamber.Based on geodetic data,we analyzed the volcanic activity according to the Global Position System(GPS)and leveling sites time-series and reestimated the location and volume change of magma chamber from 2002 to 2005.Meanwhile,we calculated the dilatational strain variations of the deep magma chamber resulting from coseismic deformations caused by the 1999 Mw7.0 and 2002 Mw7.3 Wangqing deep earthquakes and the 2011 Mw9.0 Tohoku-oki earthquake.Our results show:(1)Changbaishan has experienced four stages of unrest since 1999,and the biggest unrest of the shallow magma chamber occurred from 2002 to 2005;(2)the parameters of the shallow magma chamber simulated by the Mogi and Point Compound Dislocation Model(p DCM)show that the magma chamber is located in the northern part of the crater,with a depth of approximately 7 km.The volume of the magma chamber increased by 25-28×10^(6) m from 2002 to2005;(3)the strain variation beneath the Changbaishan volcano corresponding to the 1999 Wangqing earthquake was small.The 2002 Wangqing earthquake produced an expansion strain of about 4.4 nanostrain on the magma chamber at a depth of 550 km,and probably promoted the unrest of the Changbaishan volcano.The 2011 Tohoku earthquake induced the expansion of the shallow magma chamber and compression of the deep magma chamber.Although this event promoted shallow magma unrest,it inhibited deep magma unrest.This may explain why the Changbaishan did not show obvious unrest after the 2011 Tohoku earthquake.Therefore,more attention should be paid to earthquakes that can promote deep magma unrest in the Changbaishan volcano.展开更多
Pharmacokinetics(PK)is the study of the absorption,distribution,metabolism,and excretion(ADME)processes of a drug.Understanding PK properties is essential for drug development and precision medication.In this review w...Pharmacokinetics(PK)is the study of the absorption,distribution,metabolism,and excretion(ADME)processes of a drug.Understanding PK properties is essential for drug development and precision medication.In this review we provided an overview of recent research on PK with focus on the following aspects:(1)an update on drug-metabolizing enzymes and transporters in the determination of PK,as well as advances in xenobiotic receptors and noncoding RNAs(ncRNAs)in the modulation of PK,providing new understanding of the transcriptional and posttranscriptional regulatory mechanisms that result in inter-individual variations in pharmacotherapy;(2)current status and trends in assessing drug-drug interactions,especially interactions between drugs and herbs,between drugs and therapeutic biologies,and microbiota-mediated interactions:(3)advances in understanding the effects of diseases on PK,particularly changes in metabolizing enzymes and transporters with disease progression;(4)trends in mathematical modeling including physiologically-based PK modeling and novel animal models such as CRISPR/Cas9-based animal models for DMPK studies:(5)emerging non-classical xenobiotic metabolic pathways and the involvement of novel metabolic enzymes,especially non-P450s.Existing challenges and perspectives on future directions are discussed,and may stimulate the development of new research models,technologies,and strategies towards the development of better drugs and improved clinical practice.展开更多
Chloroquine(CQ)phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019(COVID-19).To develop a physiologically-based pharmacokinetic(PBPK)model for predicting tissue distrib...Chloroquine(CQ)phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019(COVID-19).To develop a physiologically-based pharmacokinetic(PBPK)model for predicting tissue distribution of CQ and apply it to optimize dosage regimens,a PBPK model,with parameterization of drug distribution extrapolated from animal data,was developed to predict human tissue distribution of CQ.The physiological characteristics of time-dependent accumulation was mimicked through an active transport mechanism.Several dosing regimens were proposed based on PBPK simulation combined with known clinical exposure-response relationships.The model was also validated by clinical data from Chinese patients with COVID-19.The novel PBPK model allows indepth description of the pharmacokinetics of CQ in several key organs(lung,heart,liver,and kidney),and was applied to design dosing strategies in patients with acute COVID-19(Day 1:750 mg BID,Days 2-5:500 mg BID,CQ phosphate),patients with moderate COVID-19(Day 1:750 mg and 500 mg,Days 2-3:500 mg BID,Days 4-5:250 mg BID,CQ phosphate),and other vulnerable populations(e.g.,renal and hepatic impairment and elderly patients,Days 1-5:250 mg BID,CQ phosphate).A PBPK model of CQ was successfully developed to optimize dosage regimens for patients with COVID-19.展开更多
Dear Editor,Since December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been rapidly spreading worldwide.Hydroxychloroquine and chloroquine are candidates for the treatment of coronavirus diseas...Dear Editor,Since December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been rapidly spreading worldwide.Hydroxychloroquine and chloroquine are candidates for the treatment of coronavirus disease 2019(COVID-19)owing to its antiviral effect and immunomodulation properties.展开更多
The chain length and hydrocarbon type significantly affect the production of light olefins during the catalytic pyrolysis of naphtha.Herein,for a better catalyst design and operation parameters optimization,the reacti...The chain length and hydrocarbon type significantly affect the production of light olefins during the catalytic pyrolysis of naphtha.Herein,for a better catalyst design and operation parameters optimization,the reaction pathways and equilibrium yields for the catalytic pyrolysis of C_(5-8)n/iso/cyclo-paraffins were analyzed thermodynamically.The results revealed that the thermodynamically favorable reaction pathways for n/iso-paraffins and cyclo-paraffins were the protolytic and hydrogen transfer cracking pathways,respectively.However,the formation of light paraffin severely limits the maximum selectivity toward light olefins.The dehydrogenation cracking pathway of n/iso-paraffins and the protolytic cracking pathway of cyclo-paraffins demonstrated significantly improved selectivity for light olefins.The results are thus useful as a direction for future catalyst improvements,facilitating superior reaction pathways to enhance light olefins.In addition,the equilibrium yield of light olefins increased with increasing the chain length,and the introduction of cyclo-paraffin inhibits the formation of light olefins.High temperatures and low pressures favor the formation of ethylene,and moderate temperatures and low pressures favor the formation of propylene.n-Hexane and cyclohexane mixtures gave maximum ethylene and propylene yield of approximately 49.90%and 55.77%,respectively.This work provides theoretical guidance for the development of superior catalysts and the selection of proper operation parameters for the catalytic pyrolysis of C_(5-8)n/iso/cyclo-paraffins from a thermodynamic point of view.展开更多
基金Research was supported by the National Key R&D Project from Minister of Science and Technology(2021YFA1201602)National Natural Science Foundation of China(Grant no.61774016,22109013,62204017)+1 种基金Fundamental Research Funds for the Central Universities(E1E46802)China Postdoctoral Science Foundation(2021M703172,2021M703171).
文摘Tribovoltaic nanogenerators(TVNGs)have the characteristics of high current density,low matched impedance and continuous output,which is expected to solve the problem of power supply for small electronic devices.However,wear occurrence in friction interface will seriously reduce the performance of TVNGs as well as lifetime.Here,we employ MXene solution as lubricate to improve output current density and lifetime of TVNG simultaneously,where a high value of 754 mA m^(-2)accompanied with a record durability of 90,000 cycles were achieved.By comparing multiple liquid lubricates with different polarity,we show that conductive polar liquid with MXene as additive plays a crucial role in enhancing the electrical output performance and durability of TVNG.Moreover,the universality of MXene solution is well demonstrated in various TVNGs with Cu and P-type Si,and Cu and N-GaAs as material pairs.This work may guide and accelerates the practical application of TVNG in future.
基金support from the National Key Research and Development Program of China(2018YFC1503601)Scientific Research Fund of Institute of Seismology and Institute of Crustal Dynamics,China Earthquake Administration(IS201926297)。
文摘The major earthquakes often trigger unrest of surrounding volcanic magma chambers.In recent years,three major earthquakes occurred around the Changbaishan volcano,but it was unclear whether these earthquakes triggered the unrest of the magma chamber.Based on geodetic data,we analyzed the volcanic activity according to the Global Position System(GPS)and leveling sites time-series and reestimated the location and volume change of magma chamber from 2002 to 2005.Meanwhile,we calculated the dilatational strain variations of the deep magma chamber resulting from coseismic deformations caused by the 1999 Mw7.0 and 2002 Mw7.3 Wangqing deep earthquakes and the 2011 Mw9.0 Tohoku-oki earthquake.Our results show:(1)Changbaishan has experienced four stages of unrest since 1999,and the biggest unrest of the shallow magma chamber occurred from 2002 to 2005;(2)the parameters of the shallow magma chamber simulated by the Mogi and Point Compound Dislocation Model(p DCM)show that the magma chamber is located in the northern part of the crater,with a depth of approximately 7 km.The volume of the magma chamber increased by 25-28×10^(6) m from 2002 to2005;(3)the strain variation beneath the Changbaishan volcano corresponding to the 1999 Wangqing earthquake was small.The 2002 Wangqing earthquake produced an expansion strain of about 4.4 nanostrain on the magma chamber at a depth of 550 km,and probably promoted the unrest of the Changbaishan volcano.The 2011 Tohoku earthquake induced the expansion of the shallow magma chamber and compression of the deep magma chamber.Although this event promoted shallow magma unrest,it inhibited deep magma unrest.This may explain why the Changbaishan did not show obvious unrest after the 2011 Tohoku earthquake.Therefore,more attention should be paid to earthquakes that can promote deep magma unrest in the Changbaishan volcano.
基金supported by National Natural Science Foundation of China(grants:81573489,81522047,81730103,81320108027,81660618,and 81773808)the National Key Research and Development Program(grant:2017YFE0109900 and 2017YFC0909303,China)+5 种基金the 111 project(grant:B16047,China)the Key Laboratory Foundation of Guangdong Province(grant:2017B030314030,China)Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093,China)National Engineering and Technology Research Center for New drug Druggability Evaluation(Seed Program of Guangdong Province,2017B090903004,China)Natural Science Foundation of Guangdong(grant:2017A030311018 and 2015A030313124,China)National Institutes of Health(grants No.R01CA225958 and R01GM113888 to Ai-Ming Yu,USA).
文摘Pharmacokinetics(PK)is the study of the absorption,distribution,metabolism,and excretion(ADME)processes of a drug.Understanding PK properties is essential for drug development and precision medication.In this review we provided an overview of recent research on PK with focus on the following aspects:(1)an update on drug-metabolizing enzymes and transporters in the determination of PK,as well as advances in xenobiotic receptors and noncoding RNAs(ncRNAs)in the modulation of PK,providing new understanding of the transcriptional and posttranscriptional regulatory mechanisms that result in inter-individual variations in pharmacotherapy;(2)current status and trends in assessing drug-drug interactions,especially interactions between drugs and herbs,between drugs and therapeutic biologies,and microbiota-mediated interactions:(3)advances in understanding the effects of diseases on PK,particularly changes in metabolizing enzymes and transporters with disease progression;(4)trends in mathematical modeling including physiologically-based PK modeling and novel animal models such as CRISPR/Cas9-based animal models for DMPK studies:(5)emerging non-classical xenobiotic metabolic pathways and the involvement of novel metabolic enzymes,especially non-P450s.Existing challenges and perspectives on future directions are discussed,and may stimulate the development of new research models,technologies,and strategies towards the development of better drugs and improved clinical practice.
基金supported by the“13th Five-Year”National Science and Technology Major Project(grant Nos.2017ZX09101001-002-001 and 2017ZX09304012,China)Bill&Melinda Gates Foundation(OPP1204780,USA)
文摘Chloroquine(CQ)phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019(COVID-19).To develop a physiologically-based pharmacokinetic(PBPK)model for predicting tissue distribution of CQ and apply it to optimize dosage regimens,a PBPK model,with parameterization of drug distribution extrapolated from animal data,was developed to predict human tissue distribution of CQ.The physiological characteristics of time-dependent accumulation was mimicked through an active transport mechanism.Several dosing regimens were proposed based on PBPK simulation combined with known clinical exposure-response relationships.The model was also validated by clinical data from Chinese patients with COVID-19.The novel PBPK model allows indepth description of the pharmacokinetics of CQ in several key organs(lung,heart,liver,and kidney),and was applied to design dosing strategies in patients with acute COVID-19(Day 1:750 mg BID,Days 2-5:500 mg BID,CQ phosphate),patients with moderate COVID-19(Day 1:750 mg and 500 mg,Days 2-3:500 mg BID,Days 4-5:250 mg BID,CQ phosphate),and other vulnerable populations(e.g.,renal and hepatic impairment and elderly patients,Days 1-5:250 mg BID,CQ phosphate).A PBPK model of CQ was successfully developed to optimize dosage regimens for patients with COVID-19.
基金supported by MOST(Ministry of Science and Technology of the People's Republic of China)foundation for SARS-Co V-2 Research(2020YFC0844500)the“13th Five-Year”National Science and Technology Major Project of China(2017ZX09101001-002-001,2017ZX09304012)Peking University Health Center Foundation for Combating the Pandemic Programs(BMU2020HKYZX011)。
文摘Dear Editor,Since December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been rapidly spreading worldwide.Hydroxychloroquine and chloroquine are candidates for the treatment of coronavirus disease 2019(COVID-19)owing to its antiviral effect and immunomodulation properties.
基金The authors acknowledge the support from the National Natural Science Foundation of China(Grant No.22021004)the National Key Research and Development Program of China(Grant No.2020YFA0210900)。
文摘The chain length and hydrocarbon type significantly affect the production of light olefins during the catalytic pyrolysis of naphtha.Herein,for a better catalyst design and operation parameters optimization,the reaction pathways and equilibrium yields for the catalytic pyrolysis of C_(5-8)n/iso/cyclo-paraffins were analyzed thermodynamically.The results revealed that the thermodynamically favorable reaction pathways for n/iso-paraffins and cyclo-paraffins were the protolytic and hydrogen transfer cracking pathways,respectively.However,the formation of light paraffin severely limits the maximum selectivity toward light olefins.The dehydrogenation cracking pathway of n/iso-paraffins and the protolytic cracking pathway of cyclo-paraffins demonstrated significantly improved selectivity for light olefins.The results are thus useful as a direction for future catalyst improvements,facilitating superior reaction pathways to enhance light olefins.In addition,the equilibrium yield of light olefins increased with increasing the chain length,and the introduction of cyclo-paraffin inhibits the formation of light olefins.High temperatures and low pressures favor the formation of ethylene,and moderate temperatures and low pressures favor the formation of propylene.n-Hexane and cyclohexane mixtures gave maximum ethylene and propylene yield of approximately 49.90%and 55.77%,respectively.This work provides theoretical guidance for the development of superior catalysts and the selection of proper operation parameters for the catalytic pyrolysis of C_(5-8)n/iso/cyclo-paraffins from a thermodynamic point of view.