Hemiplegia after stroke has become a major cause of the world's high disabilities,and it is vital to enhance our understanding of post-stroke neuroplasticity to develop e±cient rehabilitation programs.This st...Hemiplegia after stroke has become a major cause of the world's high disabilities,and it is vital to enhance our understanding of post-stroke neuroplasticity to develop e±cient rehabilitation programs.This study aimed to explore the brain activation and network reorganization of the motor cortex(MC)with functional near-infrared spectroscopy(fNIRS).The MC hemodynamic signals were gained from 22 stroke patients and 14 healthy subjects during a shoulder-touching task with the right hand.The MC activation pattern and network attributes analyzed with the graph theory were compared between the two groups.The results revealed that healthy controls presented dominant activation in the left MC while stroke patients exhibited dominant activation in the bilateral hemispheres MC.The MC networks for the two groups had small-world properties.Compared with healthy controls,patients had higher transitivity and lower global e±ciency(GE),mean connectivity,and long connections(LCs)in the left MC.In addition,both MC activation and network attributes were correlated with patient's upper limb motor function.The results showed the stronger compensation of the unaffected motor area,the better recovery of the upper limb motor function for patients.Moreover,the MC network possessed high clustering and relatively sparse inter-regional connections during recovery for patients.Our results promote the understanding of MC reorganization during recovery and indicate that MC activation and network could provide clinical assessment signi¯cance in stroke patients.Given the advantages of fNIRS,it shows great application potential in the assessment and rehabilitation of motor function after stroke.展开更多
Glucocorticoids(GC)are widely used to counter the adverse events during cancer therapy;nonetheless,previous studies pointed out that GC may reduce the efficacy of chemotherapy on cancer cells,especially in epidermal g...Glucocorticoids(GC)are widely used to counter the adverse events during cancer therapy;nonetheless,previous studies pointed out that GC may reduce the efficacy of chemotherapy on cancer cells,especially in epidermal growth factor receptor(EGFR)-targeted therapy of head and neck squamous cell carcinoma(HNSCC)remaining to be elucidated.The primary aim of the present study was to probe into the GC-induced resistance of EGFR-targeted drug afatinib and the underlying mechanism.HNSCC cell lines(HSC-3,SCC-25,SCC-9,and H-400)and the human oral keratinocyte(HOK)cell lines were assessed for GC receptor(GR)expression.The promoting tumor growth effect of GC was evaluated by the CCK-8 assay and flow cytometry.Levels of signaling pathways participants GR,mTOR,and EGFR were determined by quantitative polymerase chain reaction and western blotting.GC increased the proliferation of HNSCC cells in a GR-dependent manner and promoted AKT/mTOR signaling.But GC failed in counteracting the inhibition of rapamycin in the mTOR signaling pathway.Besides,GC also induced resistance to EGFR-targeted drug afatinib through AKT/mTOR instead of the EGFR/ERK signaling pathway.Thus,GCs reduce the efficacy of afatinib on HNSCC,implicating a cautious use of glucocorticoids in clinical practice.展开更多
Iron-dependent ferroptosis is a form of cell death dependent on iron levels.Cells that undergo ferroptosis have glutathione(GSH)deficiency,reduced Glutathione peroxidase-4(GPX4)activity and intracellular lipid peroxid...Iron-dependent ferroptosis is a form of cell death dependent on iron levels.Cells that undergo ferroptosis have glutathione(GSH)deficiency,reduced Glutathione peroxidase-4(GPX4)activity and intracellular lipid peroxidation,Mitochondria,lysosomes and many signal pathways are involved in the regulation of ferroptosis.More importantly,many tumor cells resistant to other cell death methods exhibit sensitivity to ferroptosis.Moreover,over recent years,a number of ferroptosis-induced drugs have been recommended for the treatment of malignant tumors.Therefore,the study of ferroptosis is of great significance for future cancer treatments.In this review,we discussed the metabolic process of ferroptosis,the role of different organelles,the typical signaling pathways involved in ferroptosis,as well as natural and synthetic compounds that can induce ferroptosis,aiming to point out new conceptual avenues for utilizing ferroptosis in future cancer treatments.展开更多
It is reported that SnSe_(2) consisting of the same elements as SnSe, is a new promising thermoelectric material with advantageous layered structure. In this work, the thermoelectric performance of polycrystalline SnS...It is reported that SnSe_(2) consisting of the same elements as SnSe, is a new promising thermoelectric material with advantageous layered structure. In this work, the thermoelectric performance of polycrystalline SnSe_(2) is improved through introducing SnSe phase and electron doping(Cl doped in Se sites). The anisotropic transport properties of SnSe_(2) are investigated. A great reduction of the thermal conductivity is achieved in SnSe_(2) through introducing SnSe phase, which mainly results from the strong SnSe_(2)–SnSe inter-phase scattering. Then the carrier concentration is optimized via Cl doping, leading to a great enhancement of the electrical transport properties, thus an extraordinary power factor of ^5.12 μW·cm^(-1)·K^(-2) is achieved along the direction parallel to the spark plasma sintering(SPS) pressure direction( P). Through the comprehensive consideration on the anisotropic thermoelectric transport properties, an enhanced figure of merit ZT is attained and reaches to ^ 0.6 at 773 K in SnSe_(2)-2% SnSe after 5% Cl doping along the P direction, which is much higher than ^ 0.13 and ^ 0.09 obtained in SnSe_(2)-2% SnSe and pristine SnSe_(2) samples, respectively.展开更多
Background:Coronavirus disease 2019(COVID-19) has shown explosive growth in cities in central China in recent days.Residents have the depression due to lack of corresponding prevention knowledge.Methods:A cross-sectio...Background:Coronavirus disease 2019(COVID-19) has shown explosive growth in cities in central China in recent days.Residents have the depression due to lack of corresponding prevention knowledge.Methods:A cross-sectional study was investigated 385 residents over 18 years of age.Structured questionnaire and DASS-21 scale used to explore the association between knowledge of prevention COVID-19 and depression among residents.Results:73 respondents (20.3%) suffered varying degrees of depression.The knowledge of the behavior of respondents most concerned (AOR 7.45,95%CI,1.87 ~ 29.77),the main symptoms of the COVID-19 (AOR 9.72,95%CI,1.19 ~ 79.12) and using special ambulances to transport patients or suspected patients (AOR 2.22,95%CI,1.07 ~ 4.62) was found to be significant related to depression.Conclusions:Although residents currently have a lower prevalence of depression,but there is a strong correlation between the knowledge and attitude of prevention COVID-19 and depression.Government agencies need to expand ways to spread the knowledge of prevention COVID-19.展开更多
Maize(Zea mays subspecies mays)is an important commercial crop across the world,and its flowering time is closely related to grain yield,plant cycle and latitude adaptation.FKF1 is an essential clock-regulated blue-li...Maize(Zea mays subspecies mays)is an important commercial crop across the world,and its flowering time is closely related to grain yield,plant cycle and latitude adaptation.FKF1 is an essential clock-regulated blue-light receptor with distinct functions on flowering time in plants,and its function in maize remains unclear.In this study,we identified two FKF1 homologs in the maize genome,named ZmFKF1a and ZmFKF1b,and indicated that ZmFKF1a and ZmFKF1b independently regulate reproductive transition through interacting with ZmCONZ1 and ZmGI1 to increase the transcription levels of ZmCONZ1 and ZCN8.We demonstrated that ZmFKF1b underwent artificial selection during modern breeding in China probably due to its role in geographical adaptation.Furthermore,our data suggested that ZmFKF1bHap_C7 may be an elite allele,which increases the abundance of ZmCONZ1 mRNA more efficiently and adapt to a wider range of temperature zone than that of ZmFKF1bHap_Z58 to promote maize floral transition.It extends our understanding of the genetic diversity of maize flowering.This allele is expected to be introduced into tropical maize germplasm to enrich breeding resources and may improve the adaptability of maize at different climate zones,especially at temperate region.展开更多
Silyl cobalt species are putative intermediates in cobalt-catalyzed transformations of hydrosilanes.However,their reactivity has remained poorly understood.Reported here is the investigation on four-coordinate disilyl...Silyl cobalt species are putative intermediates in cobalt-catalyzed transformations of hydrosilanes.However,their reactivity has remained poorly understood.Reported here is the investigation on four-coordinate disilyl Co(Ⅱ)complexes with N-hetereocyclic carbene ligation.The reactions of[(ICy)_(2)Co(vtms)](ICy=1,3-dicyclohexylimidazol-2-ylidene,vtms=vinyltrimethylsilane)with primary and secondary hydrosilanes(3 equiv.)furnish the four-coordinate disilyl complexes[trans-(ICy)_(2)Co(SiHRR')_(2)](SiHRR'=SiH_(2)Mes,1;SiH_(2)Ph,2;SiH_(2)Cy,3;SiHPh_(2),4;SiHEt_(2),5)in moderate to good yields.The structures of 1,2 and 4 were established by single-crystal X-ray diffraction.Solution magnetic susceptibility measurement and EPR spectroscopy indicate their low-spin nature(S=1/2).Reactivity studies on 4 led to the establishment of the conversions of 4 to the disilyl dihydride Co(Ⅲ)complex[K(THF)][(ICy)_(2)Co(H)_(2)(SiHPh_(2))_(2)]_n(6)and the fluorosilyl Co(Ⅱ)complex[(ICy)_(2)Co(THF)(SiFPh_(2))][BF_(4)](7)when 4 was treated with excess amount of K and AgBF_(4),respectively,in THF.These conversions hint at the high activity of low-valent and high-valent disilyl cobalt species[trans-(ICy)_(2)Co(SiHPh_(2))_(2)]^(1-)and[trans-(ICy)_(2)Co(SiHPh_(2))_(2)]^(2+).Complex 4 is reactive toward terminal alkynes,but inert toward alkenes and internal alkynes.The reactions of 4 with terminal alkynes CyC≡CH and Me_(3)SiC≡CH(3 equiv.)yield the Co(Ⅱ)complexes[(ICy)_(2)Co(C≡CCy)_(2)](8)and[(ICy)_(2)Co(C≡CSiMe_(3))((SiMe_(3))C=CH_(2))](9),respectively,along with H_(2)SiPh_(2)and alkynylsilanes RC≡CSiHPh_(2)(R=Cy,SiMe_(3)),whereas the reaction with 4-CF_(3)C_(6)H_(4)C≡CH(3 equiv.)produce[(ICy)_(2)Co(C≡CAr)((Ar)C=CH(SiHPh_(2))C=CHAr)](Ar=4-CF_(3)C_(6)H_(4))(10)and H_(2)SiPh_(2).These reactions are proposed to involveσ-bond metathesis reactions between alkyne C(sp)-H bonds and Co-Si bonds in 4.Complexes 6–10 have been characterized by NMR spectroscopy,X-ray diffraction study,and elemental analysis.展开更多
Topological photonics provides a platform for robust energy transport regardless of sharp corners and defects.Recently,the frequency multiplexing topological devices have attracted much attention due to the ability to...Topological photonics provides a platform for robust energy transport regardless of sharp corners and defects.Recently,the frequency multiplexing topological devices have attracted much attention due to the ability to separate optical signals by wavelength and hence the potential application in optical communication systems.Existing frequency multiplexing topological devices are generally based on the slow light effect.However,the resulting static local spatial mode or finely tuned flat band has zero-group velocity,making it difficult for both experimental excitation and channel out-coupling.Here,we propose and experimentally demonstrate an alternative prototype of asymmetric frequency multiplexing devices including a topological rainbow and frequency router based on floating topological edge mode(instead of localized ones);hence the multiple wavelength channels can be collectively excited with a point source and efficiently routed to separate output ports.The channel separation in our design is achieved by gradually tuning the band gap truncation on a topological edge band over a wide range of frequencies.A crucial feature lies in that the topological edge band is detached from bulk states and floating within the upper and lower photonic band gaps.More interestingly,due to the sandwiched morphology of the edge band,the top and bottom band gaps will each truncate into transport channels that support topological propagation towards opposite directions,and the asymmetrical transportation is realized for the frequency multiplexing topological devices.展开更多
The analysis of the eddy-current field in the wound core widely used in the field of transformer energy conservation is taken as the theme.Adopting the homogenisation idea to consider the unique geometry of the wound ...The analysis of the eddy-current field in the wound core widely used in the field of transformer energy conservation is taken as the theme.Adopting the homogenisation idea to consider the unique geometry of the wound core and features of its equivalent multi-stage circular cross-section magnetic boundary,a homogeneous model consisting of a columnar material with continuous homogeneous electromagnetic anisotropy is established by deriving the Maxwell equations of the magnetic quasi-static field in the columnar coordinate system.Finally,a homogeneous fine element model for the eddycurrent field in the wound core is established and the accuracy of the model has been verified by the test platform.The result shows that the homogeneous model can be effectively used for the analysis of the eddy-current field in the wound core,and the error of calculating the eddy-current loss under different excitation conditions is less than 6%under the premise of extremely saving the engineering calculation cost,which will help improve the operational performance of the wound core and contribute to the energysaving goal of the high-voltage equipment.展开更多
Noninvasive brain–computer interfaces (BCIs) show great potential in applications including sleep monitoring, fatigue alerts, neurofeedback training, etc. While noninvasive BCIs do not impose any procedural risk to u...Noninvasive brain–computer interfaces (BCIs) show great potential in applications including sleep monitoring, fatigue alerts, neurofeedback training, etc. While noninvasive BCIs do not impose any procedural risk to users (as opposed to invasive BCIs), the acquisition of high-quality electroencephalograms (EEGs) in the long term has been challenging due to the limitations of current electrodes. Herein, we developed a semidry double-layer hydrogel electrode that not only records EEG signals at a resolution comparable to that of wet electrodes but is also able to withstand up to 12 h of continuous EEG acquisition. The electrode comprises dual hydrogel layers: a conductive layer that features high conductivity, low skin-contact impedance, and high robustness;and an adhesive layer that can bond to glass or plastic substrates to reduce motion artifacts in wearing conditions. Water retention in the hydrogel is stable, and the measured skin-contact impedance of the hydrogel electrode is comparable to that of wet electrodes (conductive paste) and drastically lower than that of dry electrodes (metal pin). Cytotoxicity and skin irritation tests show that the hydrogel electrode has excellent biocompatibility. Finally, the developed hydrogel electrode was evaluated in both N170 and P300 event-related potential (ERP) tests on human volunteers. The hydrogel electrode captured the expected ERP waveforms in both the N170 and P300 tests, showing similarities in the waveforms generated by wet electrodes. In contrast, dry electrodes fail to detect the triggered potential due to low signal quality. In addition, our hydrogel electrode can acquire EEG for up to 12 h and is ready for recycled use (7-day tests). Altogether, the results suggest that our semidry double-layer hydrogel electrodes are able to detect ERPs in the long term in an easy-to-use fashion, potentially opening up numerous applications in real-life scenarios for noninvasive BCI.展开更多
Thermal characteristic is one of the key performances of dry-type on-board traction transformer(D-OBTT),which directly affects the operation safety of the new generation electric multiple units.However,due to the part...Thermal characteristic is one of the key performances of dry-type on-board traction transformer(D-OBTT),which directly affects the operation safety of the new generation electric multiple units.However,due to the particularity of train-induced wind cooling mode of D-OBTT,the existing efficient thermal modelling methods cannot be used under fluctuating air velocity and load.A time-saving transient thermal model for D-OBTT is proposed.First,the framework of the transient thermal network model(TTNM)is proposed considering the coexistence of non-fully and fully developed state of the train-induced wind and the addition heat flow in the solid domain.Then,a novel formula for calculating the length of non-fully developed section considering the geometric dimensions and heat flux density is proposed based on computational fluid dynamics(CFD)parametric sweeps for the first time.The accuracy of TTNM is validated by a D-OBTT experimental setup,and the time consumption is significantly reduced compared with CFD.展开更多
Hydrogermylation of alkenes and alkynes provides a straightforward synthetic route to organogermanium compounds that have been found applications in organic synthesis,medicinal chemistry,and material science.This pape...Hydrogermylation of alkenes and alkynes provides a straightforward synthetic route to organogermanium compounds that have been found applications in organic synthesis,medicinal chemistry,and material science.This paper reviews the advances in transition-metal-catalyzed hydrogermylation of unsaturated carbon-carbon bonds,including alkenes,alkynes,dienes,and allenes,with the objective of providing readers with the status of the field.Progress,problems,and perspectives in this field are discussed.展开更多
Chiral zeroth Landau levels are topologically protected bulk states.In particle physics and condensed matter physics,the chiral zeroth Landau level plays a significant role in breaking chiral symmetry and gives rise t...Chiral zeroth Landau levels are topologically protected bulk states.In particle physics and condensed matter physics,the chiral zeroth Landau level plays a significant role in breaking chiral symmetry and gives rise to the chiral anomaly.Previous experimental works on such chiral Landau levels are mainly based on three-dimensional Weyl degeneracies coupled with axial magnetic fields.Their realizations using two-dimensional Dirac point systems,being more promising for future applications,were never experimentally realized before.Here we propose an experimental scheme for realizing chiral Landau levels in a two-dimensional photonic system.By introducing an inhomogeneous effective mass through breaking local parity-inversion symmetries,a synthetic in-plane magnetic field is generated and coupled with the Dirac quasi-particles.Consequently,the zeroth-order chiral Landau levels can be induced,and the one-way propagation characteristics are experimentally observed.In addition,the robust transport of the chiral zeroth mode against defects in the system is also experimentally tested.Our system provides a new pathway for the realization of chiral Landau levels in two-dimensional Dirac cone systems,and may potentially be applied in device designs utilizing the chiral response and transport robustness.展开更多
Frequency domain dielectric spectroscopy(FDS)is an effective method reflecting the changes of ageing status of silicone oil‐immersed insulation paper.For better evaluating the ageing status of silicone oil‐immersed ...Frequency domain dielectric spectroscopy(FDS)is an effective method reflecting the changes of ageing status of silicone oil‐immersed insulation paper.For better evaluating the ageing status of silicone oil‐immersed insulation paper,an evaluation method was studied by analysing the ageing kinetic model and results of FDS.First,the method to separate the different polarization losses and conductivity loss from the results of FDS was studied.Then,based on the idea of ageing correction translation coefficient and timevarying pre exponential factor,the zero order ageing dynamic model was modified,which combines the ageing kinetic model with the results of FDS.Finally,the evaluation method for the degree of polymerisation(DP)of silicone oil‐immersed paper was proposed,and experiments were conducted to obtain the parameters in the modified model and then to verify the proposed method.The results show that the proposed method can be used to evaluate the DP effectively.展开更多
Sub-stoichiometric MoO_(3−x)nanostructures with plasmonic absorption via creating oxygen vacancies have attracted extensive attentions for many intriguing applications.However,the synthesis of one-dimensional(1D)plasm...Sub-stoichiometric MoO_(3−x)nanostructures with plasmonic absorption via creating oxygen vacancies have attracted extensive attentions for many intriguing applications.However,the synthesis of one-dimensional(1D)plasmonic MoO_(3−x)nanostructures with widely tunable plasmonic absorption has remained a significant challenge because of their serious morphological destruction and phase change with increasing the concentration of oxygen vacancies.Here we demonstrate a surface-ligand protected reduction strategy for the synthesis of 1D MoO_(3−x)nanobelts with tunable plasmonic absorption in a wide wavelength range from 200 to 2,500 nm.Polyethylene glycol(PEG-400)is used as both the reductant to produce oxygen vacancies and the surface protected ligands to maintain 1D morphology during the formation process of MoO_(3−x)nanobelts,enabling the widely tunable plasmonic absorption.Owing to their broad plasmonic absorption and unique 1D nanostructure,we further demonstrate the application of 1D MoO_(3−x)nanobelts as photothermal film for interfacial solar evaporator.The surface-ligand protected reduction strategy provides a new avenue for the developing plasmonic semiconductor oxides with maintained particle morphology and thus enriching their wide applications.展开更多
As a typical IV-VI compound,SnTe has aroused widely attentions in the thermoelectric community due its similar crystal and band structures with PbTe.However,both the large number of inherent Sn vacancies and high ther...As a typical IV-VI compound,SnTe has aroused widely attentions in the thermoelectric community due its similar crystal and band structures with PbTe.However,both the large number of inherent Sn vacancies and high thermal conductivity result in inferior thermoelectric performance in intrinsic SnTe over a broad temperature.In this work,we successfully improved those disadvantages of SnTe via stepwisely Pb heavily alloying and then In doping.A significantly wide fraction of Pb into SnTe(0-50%)achieves multiple effects:(a)the carrier concentration of SnTe is reduced through decreasing Sn vacancies via alloying high solution Pb atoms in the matrix;(b)the band structure is optimized through promoting the convergence of the two valence bands,simultaneously enhancing the Seebeck coefficient;(c)HAADF-STEM coupled with EDS results illustrate that guest Pb atoms randomly and uniformly occupied Sn atomic sites in the matrix,concurrently strengthening the phonon scattering.Furthermore,we introduced indium into Sn_(0.6)Pb_(0.4)Te system to create resonant states further enlarging the power factors at low-medium temperature.The integration of bands convergence and DOS distortion achieves a considerably high ZT_(ave) of~0.67 over the wide temperature range of 300-823 K in(Sn_(0.6)Pb_(0.4))_(0.995)In_(0.005)Te sample.展开更多
The train-mounted ethylene propylene rubber(EPR)cables of electric locomotive are partly restricted by the body structure and spatial layout and are in a combined envi-ronment of strong mechanical bending and thermal ...The train-mounted ethylene propylene rubber(EPR)cables of electric locomotive are partly restricted by the body structure and spatial layout and are in a combined envi-ronment of strong mechanical bending and thermal ageing.The degradation character-istics of the insulation layer have not yet received sufficient attention.In order to study the ageing characteristics of EPR cables of electric locomotive under the combined action of machine and thermal,this paper designs a bending-thermal combined ageing test platform for cables with a temperature of 135°C,bending diameter of 393.52 mm,590.28 mm and unbending cables,and tests after ageing.The product has been tested by infrared spectroscopy,scanning electron microscopy,elongation at break and broadband dielectric spectroscopy.The research results show that the bending outer part of the train-mounted EPR cable is a pain point.Under the combined action of bending and thermal,whether it is microstructure or macro performance,the degradation rate and degree of the bending of outer insulation layer are greater than the value under a single thermal ageing condition.Mechanical bending has an accelerating effect on the ageing of the EPR insulation layer.The research results can provide a reference for the ageing characteristics of the train-mounted EPR cable under the bending-thermal synergy and the evaluation of operating state of the train-mounted EPR cable under bending-thermal operating conditions.展开更多
Recently, bismuth sulfide (Bi2S3) has attracted much attention in the thermoelectric community owing to its abundance, low cost, and advanced properties. However, its poor electrical transport properties have prevente...Recently, bismuth sulfide (Bi2S3) has attracted much attention in the thermoelectric community owing to its abundance, low cost, and advanced properties. However, its poor electrical transport properties have prevented Bi2S3 devices from realizing high thermoelectric performance. In this work, our motivation is to decrease the large electrical resistivity, which is recognized as the origin of the low ZT value in undoped Bi2S3. We combined melting and spark plasma sintering (SPS) in a continuous fabrication process to produce Bi2S3–xSex (x = 0, 0.09, 0.15, 0.21) and Bi2S2.85–ySe0.15Cly (y = 0.0015, 0.0045, 0.0075, 0.015, 0.03) samples. Our results show that Se alloying at S sites can narrow the band gap and activate intrinsic electron conduction, leading to a high power factor of ~2.0 μW·cm–1·K–2 at room temperature in Bi2S2.85S0.15, about 100 times higher than that of undoped Bi2S3. Moreover, our further introduction of Cl atoms into the S sites resulted in a second-stage optimization of carrier concentration and simultaneously reduced the lattice thermal conductivity, which contributed to a high ZT value of ~0.6 at 723 K for Bi2S2.835Se0.15Cl0.015. Our results indicate that high thermoelectric performance could be realized in Bi2S3 with earth-abundant and low-cost elements.展开更多
基金was supported by the National Key Research and Development Program of China(Nos.2020YFC2004300,2020YFC2004303 and 2020YFC2004302)the National Natural Science Foundation of China(Nos.32000980 and 82171533)+1 种基金the Guangdong Basic and Applied Basic Research Foundation(Nos.2022A1515140142,2019A1515110427 and 2020B1515120014)the Key Laboratory Program of Guangdong Higher Education Institutes(No.2020KSYS001)。
文摘Hemiplegia after stroke has become a major cause of the world's high disabilities,and it is vital to enhance our understanding of post-stroke neuroplasticity to develop e±cient rehabilitation programs.This study aimed to explore the brain activation and network reorganization of the motor cortex(MC)with functional near-infrared spectroscopy(fNIRS).The MC hemodynamic signals were gained from 22 stroke patients and 14 healthy subjects during a shoulder-touching task with the right hand.The MC activation pattern and network attributes analyzed with the graph theory were compared between the two groups.The results revealed that healthy controls presented dominant activation in the left MC while stroke patients exhibited dominant activation in the bilateral hemispheres MC.The MC networks for the two groups had small-world properties.Compared with healthy controls,patients had higher transitivity and lower global e±ciency(GE),mean connectivity,and long connections(LCs)in the left MC.In addition,both MC activation and network attributes were correlated with patient's upper limb motor function.The results showed the stronger compensation of the unaffected motor area,the better recovery of the upper limb motor function for patients.Moreover,the MC network possessed high clustering and relatively sparse inter-regional connections during recovery for patients.Our results promote the understanding of MC reorganization during recovery and indicate that MC activation and network could provide clinical assessment signi¯cance in stroke patients.Given the advantages of fNIRS,it shows great application potential in the assessment and rehabilitation of motor function after stroke.
基金supported by the Research Funding(No.RCDWJS 2020-20)Research and Development Program(RD-02-202002)from West China School/Hospital of Stomatology Sichuan University+1 种基金the Natural Science Foundation of China(81902784&81872207)Sichuan Provincial Fund of China(2022YFSY0058).
文摘Glucocorticoids(GC)are widely used to counter the adverse events during cancer therapy;nonetheless,previous studies pointed out that GC may reduce the efficacy of chemotherapy on cancer cells,especially in epidermal growth factor receptor(EGFR)-targeted therapy of head and neck squamous cell carcinoma(HNSCC)remaining to be elucidated.The primary aim of the present study was to probe into the GC-induced resistance of EGFR-targeted drug afatinib and the underlying mechanism.HNSCC cell lines(HSC-3,SCC-25,SCC-9,and H-400)and the human oral keratinocyte(HOK)cell lines were assessed for GC receptor(GR)expression.The promoting tumor growth effect of GC was evaluated by the CCK-8 assay and flow cytometry.Levels of signaling pathways participants GR,mTOR,and EGFR were determined by quantitative polymerase chain reaction and western blotting.GC increased the proliferation of HNSCC cells in a GR-dependent manner and promoted AKT/mTOR signaling.But GC failed in counteracting the inhibition of rapamycin in the mTOR signaling pathway.Besides,GC also induced resistance to EGFR-targeted drug afatinib through AKT/mTOR instead of the EGFR/ERK signaling pathway.Thus,GCs reduce the efficacy of afatinib on HNSCC,implicating a cautious use of glucocorticoids in clinical practice.
基金This work was supported by the Innovation and Entrepreneurship Training Scheme for university students Program(No.C2021114631)from West China School/Hospital of Stomatology Sichuan University。
文摘Iron-dependent ferroptosis is a form of cell death dependent on iron levels.Cells that undergo ferroptosis have glutathione(GSH)deficiency,reduced Glutathione peroxidase-4(GPX4)activity and intracellular lipid peroxidation,Mitochondria,lysosomes and many signal pathways are involved in the regulation of ferroptosis.More importantly,many tumor cells resistant to other cell death methods exhibit sensitivity to ferroptosis.Moreover,over recent years,a number of ferroptosis-induced drugs have been recommended for the treatment of malignant tumors.Therefore,the study of ferroptosis is of great significance for future cancer treatments.In this review,we discussed the metabolic process of ferroptosis,the role of different organelles,the typical signaling pathways involved in ferroptosis,as well as natural and synthetic compounds that can induce ferroptosis,aiming to point out new conceptual avenues for utilizing ferroptosis in future cancer treatments.
基金supported by the Beijing Natural Science Foundation,China (Grant No. JQ18004)the National Key Research and Development Program of China(Grant Nos. 2018YFA0702100 and 2018YFB0703600)+5 种基金the National Natural Science Foundation of China (Grant No. 51772012)Shenzhen Peacock Plan Team (Grant No. KQTD2016022619565991)111 Project (Grant No. B17002)supported by the National Postdoctoral Program for Innovative Talents,China (Grant No. BX20200028)the high performance computing (HPC) resources at Beihang Universitythe support from the National Science Fund for Distinguished Young Scholars (Grant No. 51925101)。
文摘It is reported that SnSe_(2) consisting of the same elements as SnSe, is a new promising thermoelectric material with advantageous layered structure. In this work, the thermoelectric performance of polycrystalline SnSe_(2) is improved through introducing SnSe phase and electron doping(Cl doped in Se sites). The anisotropic transport properties of SnSe_(2) are investigated. A great reduction of the thermal conductivity is achieved in SnSe_(2) through introducing SnSe phase, which mainly results from the strong SnSe_(2)–SnSe inter-phase scattering. Then the carrier concentration is optimized via Cl doping, leading to a great enhancement of the electrical transport properties, thus an extraordinary power factor of ^5.12 μW·cm^(-1)·K^(-2) is achieved along the direction parallel to the spark plasma sintering(SPS) pressure direction( P). Through the comprehensive consideration on the anisotropic thermoelectric transport properties, an enhanced figure of merit ZT is attained and reaches to ^ 0.6 at 773 K in SnSe_(2)-2% SnSe after 5% Cl doping along the P direction, which is much higher than ^ 0.13 and ^ 0.09 obtained in SnSe_(2)-2% SnSe and pristine SnSe_(2) samples, respectively.
文摘Background:Coronavirus disease 2019(COVID-19) has shown explosive growth in cities in central China in recent days.Residents have the depression due to lack of corresponding prevention knowledge.Methods:A cross-sectional study was investigated 385 residents over 18 years of age.Structured questionnaire and DASS-21 scale used to explore the association between knowledge of prevention COVID-19 and depression among residents.Results:73 respondents (20.3%) suffered varying degrees of depression.The knowledge of the behavior of respondents most concerned (AOR 7.45,95%CI,1.87 ~ 29.77),the main symptoms of the COVID-19 (AOR 9.72,95%CI,1.19 ~ 79.12) and using special ambulances to transport patients or suspected patients (AOR 2.22,95%CI,1.07 ~ 4.62) was found to be significant related to depression.Conclusions:Although residents currently have a lower prevalence of depression,but there is a strong correlation between the knowledge and attitude of prevention COVID-19 and depression.Government agencies need to expand ways to spread the knowledge of prevention COVID-19.
基金supported by National Key Research and Development Program of China(2022YFF1003302)National Natural Science Foundation of China(32100491).
文摘Maize(Zea mays subspecies mays)is an important commercial crop across the world,and its flowering time is closely related to grain yield,plant cycle and latitude adaptation.FKF1 is an essential clock-regulated blue-light receptor with distinct functions on flowering time in plants,and its function in maize remains unclear.In this study,we identified two FKF1 homologs in the maize genome,named ZmFKF1a and ZmFKF1b,and indicated that ZmFKF1a and ZmFKF1b independently regulate reproductive transition through interacting with ZmCONZ1 and ZmGI1 to increase the transcription levels of ZmCONZ1 and ZCN8.We demonstrated that ZmFKF1b underwent artificial selection during modern breeding in China probably due to its role in geographical adaptation.Furthermore,our data suggested that ZmFKF1bHap_C7 may be an elite allele,which increases the abundance of ZmCONZ1 mRNA more efficiently and adapt to a wider range of temperature zone than that of ZmFKF1bHap_Z58 to promote maize floral transition.It extends our understanding of the genetic diversity of maize flowering.This allele is expected to be introduced into tropical maize germplasm to enrich breeding resources and may improve the adaptability of maize at different climate zones,especially at temperate region.
基金supported by the National Key Research and Development Program of the Ministry of Science and Technology of China(No.2021YFA1500203)Natural Science Foundation of China(Nos.22231010,22061160464,21821002,and 22201290)Shanghai Sailing Program(No.22YF1458200)。
文摘Silyl cobalt species are putative intermediates in cobalt-catalyzed transformations of hydrosilanes.However,their reactivity has remained poorly understood.Reported here is the investigation on four-coordinate disilyl Co(Ⅱ)complexes with N-hetereocyclic carbene ligation.The reactions of[(ICy)_(2)Co(vtms)](ICy=1,3-dicyclohexylimidazol-2-ylidene,vtms=vinyltrimethylsilane)with primary and secondary hydrosilanes(3 equiv.)furnish the four-coordinate disilyl complexes[trans-(ICy)_(2)Co(SiHRR')_(2)](SiHRR'=SiH_(2)Mes,1;SiH_(2)Ph,2;SiH_(2)Cy,3;SiHPh_(2),4;SiHEt_(2),5)in moderate to good yields.The structures of 1,2 and 4 were established by single-crystal X-ray diffraction.Solution magnetic susceptibility measurement and EPR spectroscopy indicate their low-spin nature(S=1/2).Reactivity studies on 4 led to the establishment of the conversions of 4 to the disilyl dihydride Co(Ⅲ)complex[K(THF)][(ICy)_(2)Co(H)_(2)(SiHPh_(2))_(2)]_n(6)and the fluorosilyl Co(Ⅱ)complex[(ICy)_(2)Co(THF)(SiFPh_(2))][BF_(4)](7)when 4 was treated with excess amount of K and AgBF_(4),respectively,in THF.These conversions hint at the high activity of low-valent and high-valent disilyl cobalt species[trans-(ICy)_(2)Co(SiHPh_(2))_(2)]^(1-)and[trans-(ICy)_(2)Co(SiHPh_(2))_(2)]^(2+).Complex 4 is reactive toward terminal alkynes,but inert toward alkenes and internal alkynes.The reactions of 4 with terminal alkynes CyC≡CH and Me_(3)SiC≡CH(3 equiv.)yield the Co(Ⅱ)complexes[(ICy)_(2)Co(C≡CCy)_(2)](8)and[(ICy)_(2)Co(C≡CSiMe_(3))((SiMe_(3))C=CH_(2))](9),respectively,along with H_(2)SiPh_(2)and alkynylsilanes RC≡CSiHPh_(2)(R=Cy,SiMe_(3)),whereas the reaction with 4-CF_(3)C_(6)H_(4)C≡CH(3 equiv.)produce[(ICy)_(2)Co(C≡CAr)((Ar)C=CH(SiHPh_(2))C=CHAr)](Ar=4-CF_(3)C_(6)H_(4))(10)and H_(2)SiPh_(2).These reactions are proposed to involveσ-bond metathesis reactions between alkyne C(sp)-H bonds and Co-Si bonds in 4.Complexes 6–10 have been characterized by NMR spectroscopy,X-ray diffraction study,and elemental analysis.
基金National Natural Science Foundation of China(62175180,62027820,62005193,11874245,12004425)Natural Science Foundation of Jiangsu Province(BK20200630).
文摘Topological photonics provides a platform for robust energy transport regardless of sharp corners and defects.Recently,the frequency multiplexing topological devices have attracted much attention due to the ability to separate optical signals by wavelength and hence the potential application in optical communication systems.Existing frequency multiplexing topological devices are generally based on the slow light effect.However,the resulting static local spatial mode or finely tuned flat band has zero-group velocity,making it difficult for both experimental excitation and channel out-coupling.Here,we propose and experimentally demonstrate an alternative prototype of asymmetric frequency multiplexing devices including a topological rainbow and frequency router based on floating topological edge mode(instead of localized ones);hence the multiple wavelength channels can be collectively excited with a point source and efficiently routed to separate output ports.The channel separation in our design is achieved by gradually tuning the band gap truncation on a topological edge band over a wide range of frequencies.A crucial feature lies in that the topological edge band is detached from bulk states and floating within the upper and lower photonic band gaps.More interestingly,due to the sandwiched morphology of the edge band,the top and bottom band gaps will each truncate into transport channels that support topological propagation towards opposite directions,and the asymmetrical transportation is realized for the frequency multiplexing topological devices.
基金National Natural Science Foundation of China under Grant,Grant/Award Number:U1834203Sichuan Science and Technology Program,Grant/Award Number:2020JDTD0009。
文摘The analysis of the eddy-current field in the wound core widely used in the field of transformer energy conservation is taken as the theme.Adopting the homogenisation idea to consider the unique geometry of the wound core and features of its equivalent multi-stage circular cross-section magnetic boundary,a homogeneous model consisting of a columnar material with continuous homogeneous electromagnetic anisotropy is established by deriving the Maxwell equations of the magnetic quasi-static field in the columnar coordinate system.Finally,a homogeneous fine element model for the eddycurrent field in the wound core is established and the accuracy of the model has been verified by the test platform.The result shows that the homogeneous model can be effectively used for the analysis of the eddy-current field in the wound core,and the error of calculating the eddy-current loss under different excitation conditions is less than 6%under the premise of extremely saving the engineering calculation cost,which will help improve the operational performance of the wound core and contribute to the energysaving goal of the high-voltage equipment.
基金This work is supported by the Ministry of Science and Technology of China(STI 2030—Major Projects 10700).
文摘Noninvasive brain–computer interfaces (BCIs) show great potential in applications including sleep monitoring, fatigue alerts, neurofeedback training, etc. While noninvasive BCIs do not impose any procedural risk to users (as opposed to invasive BCIs), the acquisition of high-quality electroencephalograms (EEGs) in the long term has been challenging due to the limitations of current electrodes. Herein, we developed a semidry double-layer hydrogel electrode that not only records EEG signals at a resolution comparable to that of wet electrodes but is also able to withstand up to 12 h of continuous EEG acquisition. The electrode comprises dual hydrogel layers: a conductive layer that features high conductivity, low skin-contact impedance, and high robustness;and an adhesive layer that can bond to glass or plastic substrates to reduce motion artifacts in wearing conditions. Water retention in the hydrogel is stable, and the measured skin-contact impedance of the hydrogel electrode is comparable to that of wet electrodes (conductive paste) and drastically lower than that of dry electrodes (metal pin). Cytotoxicity and skin irritation tests show that the hydrogel electrode has excellent biocompatibility. Finally, the developed hydrogel electrode was evaluated in both N170 and P300 event-related potential (ERP) tests on human volunteers. The hydrogel electrode captured the expected ERP waveforms in both the N170 and P300 tests, showing similarities in the waveforms generated by wet electrodes. In contrast, dry electrodes fail to detect the triggered potential due to low signal quality. In addition, our hydrogel electrode can acquire EEG for up to 12 h and is ready for recycled use (7-day tests). Altogether, the results suggest that our semidry double-layer hydrogel electrodes are able to detect ERPs in the long term in an easy-to-use fashion, potentially opening up numerous applications in real-life scenarios for noninvasive BCI.
基金National Natural Science Foundation of China,Grant/Award Numbers:U1834203,52207180Sichuan Science and Technology Plan Project(Youth Science and Technology Innovation Research Team Project),Grant/Award Number:2020JDTD0009Fundamental Research Funds for the Central Universities,Grant/Award Number:2682022CX015。
文摘Thermal characteristic is one of the key performances of dry-type on-board traction transformer(D-OBTT),which directly affects the operation safety of the new generation electric multiple units.However,due to the particularity of train-induced wind cooling mode of D-OBTT,the existing efficient thermal modelling methods cannot be used under fluctuating air velocity and load.A time-saving transient thermal model for D-OBTT is proposed.First,the framework of the transient thermal network model(TTNM)is proposed considering the coexistence of non-fully and fully developed state of the train-induced wind and the addition heat flow in the solid domain.Then,a novel formula for calculating the length of non-fully developed section considering the geometric dimensions and heat flux density is proposed based on computational fluid dynamics(CFD)parametric sweeps for the first time.The accuracy of TTNM is validated by a D-OBTT experimental setup,and the time consumption is significantly reduced compared with CFD.
基金supported by the National Key Research and Development Program of the Ministry of Science and Technology of China(2021YFA1500203)Natural Science Foundation of China(22201290,22061160464,and 21821002)Shanghai Sailing Program(22YF1458200).
文摘Hydrogermylation of alkenes and alkynes provides a straightforward synthetic route to organogermanium compounds that have been found applications in organic synthesis,medicinal chemistry,and material science.This paper reviews the advances in transition-metal-catalyzed hydrogermylation of unsaturated carbon-carbon bonds,including alkenes,alkynes,dienes,and allenes,with the objective of providing readers with the status of the field.Progress,problems,and perspectives in this field are discussed.
基金This work is supported by the Research Grants Council of Hong Kong through grants AoE/P-502/20,16307621,16307420,16310420 and Croucher Foundation(CAS20SCO1).
文摘Chiral zeroth Landau levels are topologically protected bulk states.In particle physics and condensed matter physics,the chiral zeroth Landau level plays a significant role in breaking chiral symmetry and gives rise to the chiral anomaly.Previous experimental works on such chiral Landau levels are mainly based on three-dimensional Weyl degeneracies coupled with axial magnetic fields.Their realizations using two-dimensional Dirac point systems,being more promising for future applications,were never experimentally realized before.Here we propose an experimental scheme for realizing chiral Landau levels in a two-dimensional photonic system.By introducing an inhomogeneous effective mass through breaking local parity-inversion symmetries,a synthetic in-plane magnetic field is generated and coupled with the Dirac quasi-particles.Consequently,the zeroth-order chiral Landau levels can be induced,and the one-way propagation characteristics are experimentally observed.In addition,the robust transport of the chiral zeroth mode against defects in the system is also experimentally tested.Our system provides a new pathway for the realization of chiral Landau levels in two-dimensional Dirac cone systems,and may potentially be applied in device designs utilizing the chiral response and transport robustness.
基金Sichuan Natural Science Foundation Project,Grant/Award Number:2023NSFSC0828Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2020B1515130001。
文摘Frequency domain dielectric spectroscopy(FDS)is an effective method reflecting the changes of ageing status of silicone oil‐immersed insulation paper.For better evaluating the ageing status of silicone oil‐immersed insulation paper,an evaluation method was studied by analysing the ageing kinetic model and results of FDS.First,the method to separate the different polarization losses and conductivity loss from the results of FDS was studied.Then,based on the idea of ageing correction translation coefficient and timevarying pre exponential factor,the zero order ageing dynamic model was modified,which combines the ageing kinetic model with the results of FDS.Finally,the evaluation method for the degree of polymerisation(DP)of silicone oil‐immersed paper was proposed,and experiments were conducted to obtain the parameters in the modified model and then to verify the proposed method.The results show that the proposed method can be used to evaluate the DP effectively.
基金supported by the Natural Science Foundation of Shandong Province(No.ZR2019JQ15)the National Natural Science Foundation of China(Nos.21671120 and 51972199).
文摘Sub-stoichiometric MoO_(3−x)nanostructures with plasmonic absorption via creating oxygen vacancies have attracted extensive attentions for many intriguing applications.However,the synthesis of one-dimensional(1D)plasmonic MoO_(3−x)nanostructures with widely tunable plasmonic absorption has remained a significant challenge because of their serious morphological destruction and phase change with increasing the concentration of oxygen vacancies.Here we demonstrate a surface-ligand protected reduction strategy for the synthesis of 1D MoO_(3−x)nanobelts with tunable plasmonic absorption in a wide wavelength range from 200 to 2,500 nm.Polyethylene glycol(PEG-400)is used as both the reductant to produce oxygen vacancies and the surface protected ligands to maintain 1D morphology during the formation process of MoO_(3−x)nanobelts,enabling the widely tunable plasmonic absorption.Owing to their broad plasmonic absorption and unique 1D nanostructure,we further demonstrate the application of 1D MoO_(3−x)nanobelts as photothermal film for interfacial solar evaporator.The surface-ligand protected reduction strategy provides a new avenue for the developing plasmonic semiconductor oxides with maintained particle morphology and thus enriching their wide applications.
基金supported by the National Key Research and Development Program of China(2018YFA0702100 and 2018YFB0703600)the National Natural Science Foundation of China(51772012 and 51632005)+5 种基金Shenzhen Peacock Plan team(KQTD2016022619565991)Beijing Natural Science Foundation(JQ18004)China Postdoctoral Science Foundation Grant(2019M650429)111 Project(B17002)the National Science Foundation for Distinguished Young Scholars(51925101)the financial support from Singapore Ministry of Education Tier 1grant(R-284-000-212-114)for Lee Kuan Yew Postdoctoral Fellowship。
基金supported by Beijing Natural Science Foundation (JQ18004)the National Key Research and Development Program of China (2018YFA0702100 and 2018YFB0703600)+4 种基金the National Natural Science Foundation of China (51772012)Shenzhen Peacock Plan team (KQTD2016022619565991)the National Postdoctoral Program for Innovative Talents (BX20200028)the 111 Project (B17002)support from the National Science Fund for Distinguished Young Scholars (51925101)。
基金supported by the National Key Research and Development Program of China(2018YFA0702100 and 2018YFB0703600)National Natural Science Foundation of China(51772012,51671015,52002011,52002042 and 61974042)+5 种基金Beijing Natural Science Foundation(JQ18004)National Training Program of Innovation and Entrepreneurship for undergraduates(202010006002)National Postdoctoral Programfor Innovative Talents(BX20200028)the support from the National Science Fund for Distinguished Young Scholars(51925101)the high performance computing(HPC)resources at Beihang Universitysupported by Natural Science Foundation of Chongqing,China,cstc2019jcyj-msxmX0554.
文摘As a typical IV-VI compound,SnTe has aroused widely attentions in the thermoelectric community due its similar crystal and band structures with PbTe.However,both the large number of inherent Sn vacancies and high thermal conductivity result in inferior thermoelectric performance in intrinsic SnTe over a broad temperature.In this work,we successfully improved those disadvantages of SnTe via stepwisely Pb heavily alloying and then In doping.A significantly wide fraction of Pb into SnTe(0-50%)achieves multiple effects:(a)the carrier concentration of SnTe is reduced through decreasing Sn vacancies via alloying high solution Pb atoms in the matrix;(b)the band structure is optimized through promoting the convergence of the two valence bands,simultaneously enhancing the Seebeck coefficient;(c)HAADF-STEM coupled with EDS results illustrate that guest Pb atoms randomly and uniformly occupied Sn atomic sites in the matrix,concurrently strengthening the phonon scattering.Furthermore,we introduced indium into Sn_(0.6)Pb_(0.4)Te system to create resonant states further enlarging the power factors at low-medium temperature.The integration of bands convergence and DOS distortion achieves a considerably high ZT_(ave) of~0.67 over the wide temperature range of 300-823 K in(Sn_(0.6)Pb_(0.4))_(0.995)In_(0.005)Te sample.
基金Sichuan Science and Technology Program,Grant/Award Number:2020JDTD0009。
文摘The train-mounted ethylene propylene rubber(EPR)cables of electric locomotive are partly restricted by the body structure and spatial layout and are in a combined envi-ronment of strong mechanical bending and thermal ageing.The degradation character-istics of the insulation layer have not yet received sufficient attention.In order to study the ageing characteristics of EPR cables of electric locomotive under the combined action of machine and thermal,this paper designs a bending-thermal combined ageing test platform for cables with a temperature of 135°C,bending diameter of 393.52 mm,590.28 mm and unbending cables,and tests after ageing.The product has been tested by infrared spectroscopy,scanning electron microscopy,elongation at break and broadband dielectric spectroscopy.The research results show that the bending outer part of the train-mounted EPR cable is a pain point.Under the combined action of bending and thermal,whether it is microstructure or macro performance,the degradation rate and degree of the bending of outer insulation layer are greater than the value under a single thermal ageing condition.Mechanical bending has an accelerating effect on the ageing of the EPR insulation layer.The research results can provide a reference for the ageing characteristics of the train-mounted EPR cable under the bending-thermal synergy and the evaluation of operating state of the train-mounted EPR cable under bending-thermal operating conditions.
基金supported by the National Key Research and Development Program of China under Grant No. 2018YFB0703600, the National Natural Science Foundation of China under Grant Nos. 51772012, 51671015, and 51571007the Beijing Municipal Science & Technology Commission under Grant No. Z171100002017002+2 种基金the Shenzhen Peacock Plan team under Grant No. KQTD2016022619565991111 Project under Grant No. B17002supported by the High Performance Computing Center of Henan Normal University.
文摘Recently, bismuth sulfide (Bi2S3) has attracted much attention in the thermoelectric community owing to its abundance, low cost, and advanced properties. However, its poor electrical transport properties have prevented Bi2S3 devices from realizing high thermoelectric performance. In this work, our motivation is to decrease the large electrical resistivity, which is recognized as the origin of the low ZT value in undoped Bi2S3. We combined melting and spark plasma sintering (SPS) in a continuous fabrication process to produce Bi2S3–xSex (x = 0, 0.09, 0.15, 0.21) and Bi2S2.85–ySe0.15Cly (y = 0.0015, 0.0045, 0.0075, 0.015, 0.03) samples. Our results show that Se alloying at S sites can narrow the band gap and activate intrinsic electron conduction, leading to a high power factor of ~2.0 μW·cm–1·K–2 at room temperature in Bi2S2.85S0.15, about 100 times higher than that of undoped Bi2S3. Moreover, our further introduction of Cl atoms into the S sites resulted in a second-stage optimization of carrier concentration and simultaneously reduced the lattice thermal conductivity, which contributed to a high ZT value of ~0.6 at 723 K for Bi2S2.835Se0.15Cl0.015. Our results indicate that high thermoelectric performance could be realized in Bi2S3 with earth-abundant and low-cost elements.