原发性中枢神经系统淋巴瘤MRI图像参数与分子病理的关联性分析

目的:研究原发性中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)MRI图像参数与分子病理的关联性。方法:回顾性分析2020年1月至2023年6月就诊于哈尔滨医科大学附属第一医院26例PCNSL患者资料,根据细胞来源、BCL-2表达、Ki-67指数,MAP+布鲁顿酪氨酸激酶抑制剂(Bruton's tyrosine kinase inhibitor,BTKi)治疗反应性将患者归纳至非生发中心B细胞(non-germinal center B-cell,non-GCB)组和生发中心B细胞(germinal center B-cell,GCB)组、Ki-67≥75%组和Ki-67<75%组、BCL-2+组和BCL-2-组、对MAP+BTKi方案治疗有反应组和无反应组。提取患者基线期MRI图像一阶参数如平均值、标准差、方差、变异系数、偏度、峰度、熵,比较其在两组间的差异。结果:方差、峰度、偏度、变异系数等4个参数在组间差异无统计学意义;平均数、标准差、熵这3个参数在Ki-67表达、BCL-2表达组间的差异具有统计学意义;平均数、熵这两个参数在细胞来源、治疗是否有反应性两组间差异具有统计学意义(P<0.05);对于Ki-67指数,3个参数的曲线下面积(AUC)分别为0.731、0.831、0.913;对于BCL-2表达,平均数、标准差的曲线下面积(AUC)分别为0.889和0.938。多参数联合分析时其鉴识效果较利用单个纹理分析定量参数更高。结论:平均值、标准差、熵等3个MRI参数有助于预测PCNSL患者Ki-67、BCL-2的表达,对于治疗具有一定评估作用,有利于术前无创性评估肿瘤的恶性程度并为预后和治疗提供新的依据。

Research on the Communication and Development of Heilongjiang Cultural and Creative Industry under the Background of“Belt and Road”

This paper focuses on the research on the dissemination and development of cultural and creative industries in Heilongjiang Province under the background of“Belt and Road.”Firstly,the paper analyzes the main characteristics of cultural and creative industries in Heilongjiang Province and then puts forward the leading advantages of the government to promote the development of cultural and creative industries.The government gives full play to its regional advantages and creates Longjiang cultural products,while also accelerating regional industrial cooperation and innovative cultural communication forms.In-depth discussion is made on integrating scientific and technological means of the times and strengthening the cultivation of innovative talents.The government optimizes the communication and development path of the Heilongjiang cultural entrepreneurship industry and brings positive influence to the stable development of the Heilongjiang region in the future.

TRIM59在非小细胞肺癌中的表达及其与预后的关系

背景与目的TRIM家族蛋白是E3泛素连接酶的重要成员,诸多研究证实TRIM家族成员在多种肿瘤的发生发展中发挥了重要作用。前期我们通过高通量测序发现TRIM59 mRNA在非小细胞肺癌组织中表达明显升高。本研究旨在探讨TRIM59在非小细胞肺癌中的表达变化及其与患者临床病理特征和预后的关系。方法检索高通量芯片表达谱数据库(Gene Expression Omnibus,GEO)和肿瘤基因组计划(The Cancer Genome Atlas,TCGA)数据库中的非小细胞肺癌基因表达谱数据和临床数据,分析TRIM59 mRNA的表达与非小细胞肺癌患者预后的关系;采用免疫组织化学染色的方法检测TRIM59蛋白在90例肺癌组织及癌旁组织中表达,分析TRIM59蛋白的表达与患者临床病理参数及预后的关系。结果TRIM59 mRNA在肺癌组织中表达明显升高并提示预后不良;TRIM59蛋白在肺癌组织中高表达,在癌旁组织低表达或不表达,TRIM59蛋白的表达与肿瘤大小(P=0.007)、病理分级(P=0.009)、肿瘤原发灶-淋巴结-转移(tumor-node-metastasis,TNM)分期(P=0.003)和淋巴结转移(P=0.003)密切相关。TRIM59蛋白高表达的患者预后较差,Cox多因素回归分析发现TRIM59蛋白的表达和TNM分期是影响患者预后的独立危险因素。结论TRIM59的表达水平与非小细胞肺癌的预后密切相关,是影响患者预后的独立危险因素。

ADRC based control for a class of input time delay systems

This paper is concerned with the control design and the theoretical analysis for a class of input time-delay systems with stable, critical stable or unstable poles. In order to overcome the time delay, a novel feed-forward compensation active disturbance rejection control(FFC-ADRC) approach is proposed. It combines advantages of the Smith predictor and the traditional active disturbance rejection control(ADRC). The tracking differentiator(TD) is designed to predict the control signal, which adds an anticipatory control to the control signal and allows a higher observer bandwidth to obtain better disturbance rejection. The modified extended state observer(ESO) is designed to estimate both system states and the total disturbances(internal disturbance, uncertainties and delayed disturbance). Then the Lyapunov theory and the theory of the input-output stability are applied to prove the asymptotic stability of the closed-loop control system. Finally, numerical simulations show the effectiveness and practicality of the proposed design.

Characterization of interfaces: Lessons from the past for the future of perovskite solar cells

A photovoltaic technology historically goes through two major steps to evolve into a mature technology. The first step involves advances in materials and is usually accompanied by the rapid improvement of power conversion efficiency. The second step focuses on interfaces and is usually accompanied by significant stability improvement. As an emerging generation of photovoltaic technology, perovskite solar cells are transitioning to the second step of their development when a significant focus shifts toward interface studies and engineering. While various interface engineering strategies have been developed, interfacial characterization is crucial to show the effectiveness of interfacial modification. Here, we review the characterization techniques that have been utilized in studying interface properties in perovskite solar cells. We first summarize the main roles of interfaces in perovskite solar cells, and then we discuss some typical characterization methodologies for morphological, optical,and electrical studies of interfaces. Successful experiences and existing problems are analyzed when discussing some commonly used methods. We then analyze the challenges and provide an outlook for further development of interfacial characterizations. This review aims to evoke strengthened research devotion on novel and persuasive interfacial engineering.

Inflammation responsive tofacitinib loaded albumin nanomedicine for targeted synergistic therapy in ulcerative colitis

Patients with ulcerative colitis(UC)often loss responses over long term usage of conventional therapies.Tofacitinib,a pan-Janus kinases(JAK)inhibitor is approved for moderate to severe UC treatment,while dose-limiting systemic side effects including infections,cancers and lymphoma limit its popularity of clinical application.This study sought to construct an anti-mucosal vascular addressin cell-adhesion molecule-1(anti-MAdCAM-1)antibody modified reactive oxygen species(ROS)responsive human serum albumin-based nanomedicine denoted as THM,to improve the therapeutic efficacy of tofacitinib for UC treatment.THM has the drug releasing properties in response to ROS stimulation.In vitro studies show that THM selectively adhered to the endothelial cells and had obvious anti-inflammatory effect on macrophages.Meanwhile,the nanomedicine can inhibit the phenotypic switching of M1 macrophages and promote M2 polarization to produce anti-inflammatory medicators during wound healing.In addition,in vivo fluorescence imaging verified that THM exhibited enhanced preferential accumulation and extended retention in inflamed colon.Moreover,THM significantly reduced the production of proinflammatory cytokines in the colon and suppressed the homing of T cells to the gut in dextran sodium sulfate induced experimental colitis.This work elucidates that the inflamed colon-targeted delivery of tofacitinib by nanomedicine is promising for UC treatment and sheds light on addressing the unmet medical need.

Design and experiment of a novel pneumatic soft arm based on a deployable origami exoskeleton

Soft arms have shown great application potential because of their flexibility and compliance in unstructured environments.However,soft arms made from soft materials exhibit limited cargo-loading capacity,which restricts their ability to manipulate objects.In this research,a novel soft arm was developed by coupling a rigid origami exoskeleton with soft airbags.The joint module of the soft arm was composed of a deployable origami exoskeleton and three soft airbags.The motion and load performance of the soft arm of the eight-joint module was tested.The developed soft arm withstood at least 5 kg of load during extension,contraction,and bending motions;exhibited bistable characteristics in both fully contracted and fully extended states;and achieved a bending angle of more than 240°and a contraction ratio of more than 300%.In addition,the high extension,contraction,bending,and torsional stiffnesses of the soft arm were experimentally demonstrated.A kinematic-based trajectory planning of the soft arm was performed to evaluate its error in repetitive motion.This work will provide new design ideas and methods for flexible manipulation applications of soft arms.

High loading cotton cellulose-based aerogel self-standing electrode for Li-S batteries

Lithium-sulfur(Li-S) batteries have attracted considerable attention due to their high energy density(2600 Wh kg-1). However, its commercialization is hindered seriously by the low loading and utilization rate of sulfur cathodes. Herein, we designed the cellulose-based graphene carbon composite aerogel(CCA) self-standing electrode to enhance the performance of Li-S batteries. The CCA contributes to the mass loading and utilization efficiency of sulfur, because of its unique physical structure: low density(0.018 g cm-3), large specific surface area(657.85 m2 g-1), high porosity(96%), and remarkable electrolyte adsorption(42.25 times). Compared to Al(about 49%), the CCA displayed excellent sulfur use efficiency(86%) and could reach to high area capacity of 8.60 mAh cm-2 with 9.11 mgS loading. Meanwhile,the CCA exhibits the excellent potential for pulse sensing applications due to its flexibility and superior sensitivity to electrical response signals.

Influence of Tip Clearance on Performance of a Contra-Rotating Fan

Influences of tip clearance on the tip flow and associated loss mechanism in a contra-rotating axial flow fan hasbeen studied in the paper, based on three dimensional numerical results. The results with different tip clearanceare compared in terms of stage efficiency, relative total pressure loss coefficient, flow angle. It is found that theefficiency of the contra-rotating fan changes almost linearly with increment of the tip clearance, however, efficiencyof the rear rotor is observed to decrease more dramatically than that of the forward rotor given same tipclearance variation. The analysis on the flow structure indicates that the tip region flow field is qualitatively similarin both rotors. However, with the same clearance value, the leakage flow in the rear rotor is effected by a tipleakage vortex of greater intensity caused by relative loading levels and the inter rotor interaction.

Effects of processing additives in non-fullerene organic bulk heterojunction solar cells with efficiency >11%

Here we investigate processing additive-dependent photovoltaic performance and charge recombination in organic bulk heterojunction(BHJ) solar cells based on a polymeric donor of PBDB-T blended with a non-fullerene acceptor m-ITIC. We find that PBDB-T:m-ITIC solar cells exhibit good compatibilities with the utilized additives(DIO, CN, DPE, and NMP) in optimal conditions, can have a high charge dissociation probability approaching 100%(with DIO), leading to ultimate efficiency >11%. Regardless of additives, we observe a dominant 1 st order monomolecular recombination with insignificant bi-molecular recombination or space-charge effects in these solar cells. Despite of impressive power conversion efficiency(PCE), it is of surprise that Shockley-Read-Hall recombination is identified to play a role in device operation. Thus, it points to the necessity to mitigate the influences of traps to further boost the efficiency in non-fullerene based organic solar cells.

Molecular dispersion enhances photovoltaic efficiency and thermal stability in quasi-bilayer organic solar cells

In comparison to widely adopted bulk heterojunction(BHJ)structures for organic solar cells(OSC),exploiting the sequential deposition to form planar heterojunction(PHJ)structures enables to realize the favorable vertical phase separation to facilitate charge extraction and reduce charge recombination in OSCs.However,effective tunings on the power conversion efficiency(PCE)in PHJ-OSCs are still restrained by the currently available methods.Based on a polymeric donor PBDBT-2 F(PBDBT=Poly[[4,8-bis[5-(2-ethylhexyl)-4-fluoro-2-thienyl]benzo[1,2-b:4,5-b′]dithiophene-2,6-diyl]-2,5-thiophenediyl[5,7-bis(2-ethylhexyl)-4,8-dioxo-4 H,8 H-benzo[1,2-c:4,5-c′]dithiophene-1,3-diyl]-2,5-thiophenediyl])and a non-fullerene(NF)acceptor Y6,we proposed a strategy to improve the properties of photovoltaic performances in PHJ-based OSCs through dilute dispersions of the PBDBT-2 F donor into the acceptor-dominant phase with the sequential film deposition.With the control of donor dispersions,the charge transport balance in the PHJ-OSCs is improved,leading to the expedited photocarrier sweep-out with reduced bimolecular charge recombination.As a result,a PCE of 15.4%is achieved in the PHJ-OSCs.Importantly,the PHJ solar cells with donor dispersions exhibit better thermal stability than corresponding BHJ devices,which is related to the better film morphology robustness and less affected charge sweep-out during the thermal aging.

Advanced near-infrared light approaches for neuroimaging and neuromodulation

Almost all physiological processes of animals are controlled by the brain,including language,cognitive,memory,learning,emotion and so forth.Minor brain dysfunction usually leads to brain diseases and disorders.Therefore,it'is greatly meaningful and urgent for scientists to have a better understanding of brain structure and function.Optical approaches can provide powerful tools for imaging and modulating physiological processes of the brain.In particular,optical approaches in the near-infrared(NIR)window(700-1700 nm)exhibit excellent prosperities of deep tissue penetration and low tissue scattering and absorption compared with those of visible windows(400-700 nm),which provides a promising approach for scientists to develop desired methods of neuroimaging and neuromodulation in deep brain tissues.In this review,variable types of NIR light approaches for imaging and modulating neural ions,membrane potential,neurotransmitters,and other critical molecules for brain functions and diseases are summarized.In particular,the latest breakthrough research of brain imaging and brain regulation in the NIR-II window(1000-1700 nm)are highlighted.Finally,we conclude the challenges and prospects of NIR light-based neuroimaging and neuromodulation for both basic brain research and further clinical translation.