Dear Editor,A series of novel coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)since the end of 2019 is ongoing and triggering a global public health crisis.The es...Dear Editor,A series of novel coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)since the end of 2019 is ongoing and triggering a global public health crisis.The estimated case fatality rate is approximately 3.4%in China.However,some patients experience dyspnea within 1 week and develop rapidly to organ injury and even death within 2 weeks after dyspnea.1 In addition,early organ injury could lead to higher risks of mortality.Thus,early identification of patients at risk of organ injury and death is crucial,which saves the patients from classified and invasive treatment,improving clinical outcome and prognosis.The human immune system plays significant roles in the resistance of foreign pathogens and the progress of pneumonia.Recent studies have mentioned that T cells were decreased in COVID-19 patients,excessive activated immune response was caused by pathogenic Th1 cells,and inflammatory CD14+CD16+monocytes may connect to pulmonary immunopathology,leading to deleterious clinical manifestations and even acute mortality after SARS-CoV-2 infections.2 SARS-CoV-2 might damage lymphocytes,especially T lymphocytes,and the immune system was impaired during the period of disease to cause tissue injury.展开更多
One of the major challenges when fabricating high gamut colour-converted micro-light-emitting diodes(LEDs)displays is severe crosstalk effect among adjacent pixels because of the wide view-angle feature of micro-LED c...One of the major challenges when fabricating high gamut colour-converted micro-light-emitting diodes(LEDs)displays is severe crosstalk effect among adjacent pixels because of the wide view-angle feature of micro-LED chips.In this study,potential factors that contribute to the crosstalk effect were systematically simulated.We observed that precisely filling the space between each micro-LED chip with a light blocking matrix(LBM)can be a promising solution to alleviate this risk.After careful investigations,a press-assisted moulding technique was demonstrated to be an effective approach of fabricating the LBM.Nevertheless,experimental observations further revealed that residual black LBM on the surface of micro-LEDs severely reduces the brightness,thereby compromising the display performance.This problem was successfully addressed by employing a plasma etching technique to efficiently extract the trapped light.Eventually,a top-emitting blue micro-LED-based backlight fine-moulded with a black LBM was developed and combined with red and green quantum dot colour-conversion layers for full-colour display.The colour gamut of our manufactured display prototype can cover as high as 122%that of the National Television Standards Committee.展开更多
基金This work was supported by the National Natural Science Foundation of China （Nos. 21373097 and 51072067） and the National Basic Research Program of China （No. 2011CB935800）.
文摘Dear Editor,A series of novel coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)since the end of 2019 is ongoing and triggering a global public health crisis.The estimated case fatality rate is approximately 3.4%in China.However,some patients experience dyspnea within 1 week and develop rapidly to organ injury and even death within 2 weeks after dyspnea.1 In addition,early organ injury could lead to higher risks of mortality.Thus,early identification of patients at risk of organ injury and death is crucial,which saves the patients from classified and invasive treatment,improving clinical outcome and prognosis.The human immune system plays significant roles in the resistance of foreign pathogens and the progress of pneumonia.Recent studies have mentioned that T cells were decreased in COVID-19 patients,excessive activated immune response was caused by pathogenic Th1 cells,and inflammatory CD14+CD16+monocytes may connect to pulmonary immunopathology,leading to deleterious clinical manifestations and even acute mortality after SARS-CoV-2 infections.2 SARS-CoV-2 might damage lymphocytes,especially T lymphocytes,and the immune system was impaired during the period of disease to cause tissue injury.
基金This work was financially supported by the Guangdong Basic and Applied Basic Research Foundation(No.2021A1515110085)Key-Area Research and Development Program of Guangdong Province(No.2019B010924003)+2 种基金Shenzhen Hong Kong Innovation Circle Joint R&D Project(SGDX20190918105201704)Shenzhen Fundamental Research Program(No.GXWD20201231165807007-20200810113811001)Shenzhen Science and Technology Research Grant(JCYJ20170818085627903).
文摘One of the major challenges when fabricating high gamut colour-converted micro-light-emitting diodes(LEDs)displays is severe crosstalk effect among adjacent pixels because of the wide view-angle feature of micro-LED chips.In this study,potential factors that contribute to the crosstalk effect were systematically simulated.We observed that precisely filling the space between each micro-LED chip with a light blocking matrix(LBM)can be a promising solution to alleviate this risk.After careful investigations,a press-assisted moulding technique was demonstrated to be an effective approach of fabricating the LBM.Nevertheless,experimental observations further revealed that residual black LBM on the surface of micro-LEDs severely reduces the brightness,thereby compromising the display performance.This problem was successfully addressed by employing a plasma etching technique to efficiently extract the trapped light.Eventually,a top-emitting blue micro-LED-based backlight fine-moulded with a black LBM was developed and combined with red and green quantum dot colour-conversion layers for full-colour display.The colour gamut of our manufactured display prototype can cover as high as 122%that of the National Television Standards Committee.
