he immune system can robustly respond to pathogens, while it is capableor malntaining Itolerance to self and innocu- ous antigens, so that the body is not jeopar- dized by autoimmune reactivity. Under certain circumst...he immune system can robustly respond to pathogens, while it is capableor malntaining Itolerance to self and innocu- ous antigens, so that the body is not jeopar- dized by autoimmune reactivity. Under certain circumstances, nonetheless, control of homeostasis of the immune system is sus- pended, and the body subsequently fails to recognize its own constituent parts as self, which contributes to homeostatic peripheral expansion and autoimmune diseases. Although autoimmunity is extensively studied, the ori- gins of this increasing public health challenge remain not well understood.展开更多
文摘he immune system can robustly respond to pathogens, while it is capableor malntaining Itolerance to self and innocu- ous antigens, so that the body is not jeopar- dized by autoimmune reactivity. Under certain circumstances, nonetheless, control of homeostasis of the immune system is sus- pended, and the body subsequently fails to recognize its own constituent parts as self, which contributes to homeostatic peripheral expansion and autoimmune diseases. Although autoimmunity is extensively studied, the ori- gins of this increasing public health challenge remain not well understood.
