系统性红斑狼疮患者血清PS-PLA1、CCL19、IL-17、IL-23表达水平与病情活动度的相关性分析

目的分析系统性红斑狼疮患者血清磷脂酰丝氨酸特异性磷脂酶A1(serum phosphatidylserine-specific phospholipase A1,PS-PLA1)、趋化因子配体19(chemokine ligand 19,CCL19)、白细胞介素17(interleukin-17,IL-17)、白细胞介素23(interleukin-23,IL-23)表达水平与病情活动度的相关性。方法回顾性收集系统性红斑狼疮患者103例的临床资料,根据患者系统性红斑狼疮疾病活动度评分(systemic lupus erythematosus disease activity score,SLEDAI)将其分为轻度亚组(31例)、中度亚组(50例)、重度亚组(22例),另选择同期健康体检人群62例作为对照组。比较研究组和对照组血常规[白细胞计数(white blood cell count,WBC)、淋巴细胞百分比(lymphocyte percentage,LY%)、血小板(platelet,PLT)、血红蛋白(hemoglobin,Hb)]及免疫功能[血清免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白M(immunoglobulin M,IgM)、补体C3、补体C4]相关指标水平,比较研究组和对照组、各亚组血清PS-PLA1、CCL19、IL-17、IL-23水平。通过Pearson相关性分析法分析PS-PLA1、CCL19、IL-17、IL-23与血常规、免疫功能相关指标的相关性。结果研究组全血WBC、LY%、PLT、Hb、补体C3、补体C4水平低于对照组,血清IgG、IgA、IgM水平高于对照组(P<0.05)。研究组血清PS-PLA1、CCL19、IL-17、IL-23水平高于对照组(P<0.05)。重度亚组血清PS-PLA1、CCL19、IL-17、IL-23水平高于轻度亚组、中度亚组,中度亚组血清PS-PLA1、CCL19、IL-17、IL-23水平高于轻度亚组(P<0.05)。Pearson相关性分析法结果显示,PS-PLA1与IgG表达呈正相关(P<0.05),CCL19、IL-17、IL-23与IgG、IgA、IgM表达呈正相关(P<0.05),IL-17、IL-23与补体C3表达呈负相关(P<0.05)。结论系统性红斑狼疮患者血清PS-PLA1、CCL19、IL-17、IL-23水平升高,且其水平与患者病情活动度及细胞免疫功能障碍有关,可能作为系统性红斑狼疮临床诊治的新靶点。

Therapeutic observation on tuina at head and abdomen for headache due to phlegm turbidity

Objective:To observe the clinical efficacy of tuina at head and abdomen for headache due to phlegm turbidity.Methods:A total of 56 patients with headache due to phlegm turbidity were randomized into a tuina group and a Chinese medicine group by the random number table,with 28 cases in each group.The tuina group was treated mainly with tuina at the head and abdomen,while the Chinese medicine group was treated with oral administration of Ban Xia Bai Zhu Tian Ma Tang(Pinellio,Atractylodes Mocrocepholo and Gastrodio Decoction).The course of treatment was 30 d.The scores of headache index,traditional Chinese medicine syndrome scale,and the therapeutic efficacy were observed.Results:There were 2 dropouts in each group during treatment.The total effective rate was 92.3%in the tuina group,significantly higher than 76.9%in the Chinese medicine group(P<0.05).The scores of headache index and traditional Chinese medicine syndrome scale in both groups decreased after treatment(both P<0.05),and scores in the tuina group were lower than those in the Chinese medicine group(both P<0.05).Conclusion:Tuina mainly at head and abdomen is effective in treating headache due to phlegm turbidity,and has a better effect than Ban Xia Bai Zhu Tian Ma Tang(Pinellia,Atractylodes Macrocephalo and Gastrodio Decoction).