Clinical study on Salvia Miltiorrhiza + calcium dobesilate treatment of early retinopathy of type 2 diabetes mellitus

Objective:To study the efficacy of Salvia Miltiorrhiza+calcium dobesilate for early retinopathy of type 2 diabetes mellitus.Methods:The patients with non-proliferative diabetic retinopathy admitted to our hospital between August 2016 and February 2018 were chosen and randomly divided into the observation group receiving Salvia Miltiorrhiza+calcium dobesilate treatment and the control group receiving calcium dobesilate treatment.Before treatment and 3 months after treatment,ophthalmologic examination was conducted to measure the hemangioma volume,macular thickness and blood spot area,and serum was collected to measure the contents of angiogenesis molecules,inflammation molecules and oxidative stress molecules.Results:The hemangioma volume,macular thickness and blood spot area as well as serum hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor(VEGF),erythropoietin(EPO),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),intercellular adhesion molecule-1(ICAM-1),malondialdehyde(MDA)and advanced oxidation protein product(AOPP)levels of both groups were significantly lower whereas serum pigment epithelium-derived factor(PEDF),heme oxygenase-1(HO-1),vitamin E(VitE)and total antioxidant capacity(TAC)levels were significantly higher after treatment,and the hemangioma volume,macular thickness and blood spot area as well as serum HIF-1α,VEGF,EPO,IL-1β,TNF-α,ICAM-1,MDA and AOPP levels of observation group after treatment were significantly lower than those of control group whereas serum PEDF,HO-1,VitE and TAC levels were significantly higher than those of control group.Conclusion:Salvia Miltiorrhiza+calcium dobesilate treatment of early retinopathy of type 2 diabetes mellitus is more effective than calcium dobesilate alone in improving the condition and inhibiting the angiogenesis,inflammation and oxidative stress.