Innate immune signaling plays a significant role in the rapid cellular responses against foreign entities.An inflam-masome is a large cytosolic polymer of a pattern recognition receptor with/without an adaptor protein...Innate immune signaling plays a significant role in the rapid cellular responses against foreign entities.An inflam-masome is a large cytosolic polymer of a pattern recognition receptor with/without an adaptor protein,formed in response to these entities.Canonically,an inflammasome can recruit and lead to auto-activation of caspase-1,subsequent maturation and secretion of inflammatory cytokines,and pyroptosis.One particular inflammasome,the noncanonical inflammasome,is formed by caspase-4 or-5(mouse caspase-11)upon binding of lipopolysac-charide and is essential for controlling gram-negative bacterial infection.However,prolonged hyper-activation of the non-canonical inflammasome has been implicated in the pathogenesis of inflammatory diseases and endotox-emia sepsis.This review will summarize the recent advances on the noncanonical inflammasome,its mechanism of activation,key cellular regulators and role in health and disease.展开更多
基金funded in part by National Institutes of Health grants to P.W,R01AI132526,and an UConn Health startup fund to P.W.
文摘Innate immune signaling plays a significant role in the rapid cellular responses against foreign entities.An inflam-masome is a large cytosolic polymer of a pattern recognition receptor with/without an adaptor protein,formed in response to these entities.Canonically,an inflammasome can recruit and lead to auto-activation of caspase-1,subsequent maturation and secretion of inflammatory cytokines,and pyroptosis.One particular inflammasome,the noncanonical inflammasome,is formed by caspase-4 or-5(mouse caspase-11)upon binding of lipopolysac-charide and is essential for controlling gram-negative bacterial infection.However,prolonged hyper-activation of the non-canonical inflammasome has been implicated in the pathogenesis of inflammatory diseases and endotox-emia sepsis.This review will summarize the recent advances on the noncanonical inflammasome,its mechanism of activation,key cellular regulators and role in health and disease.
