Migraine pathophysiology possibly involves deficient mitochondrial energy res erve and diminished cortical habituation. Using functional magnetic resonance sp ectroscopic imaging (fMRSI), we studied cortical lactate c...Migraine pathophysiology possibly involves deficient mitochondrial energy res erve and diminished cortical habituation. Using functional magnetic resonance sp ectroscopic imaging (fMRSI), we studied cortical lactate changes during prolonge d visual stimulation to search for different pathophysiological mechanisms in cl inically distinct subgroups of migraine with aura. Eleven healthy volunteers (HV ) and 10 migraine patients were investigated interictally: five with visual aura (MA) and five with visual symptoms and at least one of the following: paraesthe sia, paresis or dysphasia (MAplus). Using MRSI (Philips, 1.5 T) 1H- spectra wer e repeatedly obtained from a 25 mm- thick slice covering visual and non- visua l cortex, with the first and fifth measurements in darkness and the second to fo urth with 8- Hz checkerboard stimulation. In MAplus lactate increased only duri ng stimulation, only in visual cortex; in MA resting lactate was high in visual cortex, without further increase during stimulation. This is compatible with an abnormal metabolic strain during stimulation in MAplus, possibly due to dishabit uation, and a predominant mitochondrial dysfunction in MA.展开更多
文摘Migraine pathophysiology possibly involves deficient mitochondrial energy res erve and diminished cortical habituation. Using functional magnetic resonance sp ectroscopic imaging (fMRSI), we studied cortical lactate changes during prolonge d visual stimulation to search for different pathophysiological mechanisms in cl inically distinct subgroups of migraine with aura. Eleven healthy volunteers (HV ) and 10 migraine patients were investigated interictally: five with visual aura (MA) and five with visual symptoms and at least one of the following: paraesthe sia, paresis or dysphasia (MAplus). Using MRSI (Philips, 1.5 T) 1H- spectra wer e repeatedly obtained from a 25 mm- thick slice covering visual and non- visua l cortex, with the first and fifth measurements in darkness and the second to fo urth with 8- Hz checkerboard stimulation. In MAplus lactate increased only duri ng stimulation, only in visual cortex; in MA resting lactate was high in visual cortex, without further increase during stimulation. This is compatible with an abnormal metabolic strain during stimulation in MAplus, possibly due to dishabit uation, and a predominant mitochondrial dysfunction in MA.
