X-linked agammaglobulinemia also known as Bruton’s disease, is a humoral immunodeficiency disease characterized by recurrent bacterial infections due to low levels or absence of serum immunoglobulins. It has been sho...X-linked agammaglobulinemia also known as Bruton’s disease, is a humoral immunodeficiency disease characterized by recurrent bacterial infections due to low levels or absence of serum immunoglobulins. It has been shown to be caused by mutations in the gene encoding Bruton tyrosine kinase. Although bacterial infections typically begins 6-9 months after birth when maternal IgG is reduced below the protective level, the diagnosis is established before 5 years of age. Here we report a case with Bruton’s disease and recurrent pneumonia?that is typical of the late diagnosed disease. This report suggests the importance of evaluating patients with recurrent infections for immunodeficiency diseases.展开更多
Background:The effects of Helicobacter pylori(H.pylori)infection on growth are a controversial issue.We investigated the effects of long-term H.pylori infection on height and weight in children.Methods:A total of 200 ...Background:The effects of Helicobacter pylori(H.pylori)infection on growth are a controversial issue.We investigated the effects of long-term H.pylori infection on height and weight in children.Methods:A total of 200 children of 7-18 years old suffering from dyspeptic complaints were classified into two groups:H.pylori positive and negative groups,respectively.Whether the infection was impoved was followed up while performing urea breath test,and according to exposure time to the infection,the children were further divided into group 1(≤1.5 months),group 2(>1.5-≤6 months)and group 3(>6 months).Antropometric measurements were obtained and repeated every six months.Results:Mean growth velocity scores in the H.pylori positive and negative groups were 0.49±3.85[95%confidence interval(CI):-0.21-1.18]and 1.98±4.42(95%CI:1-2.96),respectively.The difference between both groups was statistically significant(P=0.012).Mean growth velocity scores in groups 1,2 and 3 were 0.96±3.84,0.16±4.51 and-0.85±3.09,respectively.Mean growth velocity scores of group 3 were significantly lower than those of groups 0 and 1(P=0.005 and P=0.041).The mean weight scores in group 3 were similar to those in group 2,but the scores in group 3 were signifi cantly lower than those in group 1(-1.75±1.05,-1.21±1.37 and-0.88±1.49,respectively).Conclusion:As the duration of exposure is prolonged in children with H.pylori infection,the negative effect of the infection on both height and weight is evident.展开更多
文摘X-linked agammaglobulinemia also known as Bruton’s disease, is a humoral immunodeficiency disease characterized by recurrent bacterial infections due to low levels or absence of serum immunoglobulins. It has been shown to be caused by mutations in the gene encoding Bruton tyrosine kinase. Although bacterial infections typically begins 6-9 months after birth when maternal IgG is reduced below the protective level, the diagnosis is established before 5 years of age. Here we report a case with Bruton’s disease and recurrent pneumonia?that is typical of the late diagnosed disease. This report suggests the importance of evaluating patients with recurrent infections for immunodeficiency diseases.
文摘Background:The effects of Helicobacter pylori(H.pylori)infection on growth are a controversial issue.We investigated the effects of long-term H.pylori infection on height and weight in children.Methods:A total of 200 children of 7-18 years old suffering from dyspeptic complaints were classified into two groups:H.pylori positive and negative groups,respectively.Whether the infection was impoved was followed up while performing urea breath test,and according to exposure time to the infection,the children were further divided into group 1(≤1.5 months),group 2(>1.5-≤6 months)and group 3(>6 months).Antropometric measurements were obtained and repeated every six months.Results:Mean growth velocity scores in the H.pylori positive and negative groups were 0.49±3.85[95%confidence interval(CI):-0.21-1.18]and 1.98±4.42(95%CI:1-2.96),respectively.The difference between both groups was statistically significant(P=0.012).Mean growth velocity scores in groups 1,2 and 3 were 0.96±3.84,0.16±4.51 and-0.85±3.09,respectively.Mean growth velocity scores of group 3 were significantly lower than those of groups 0 and 1(P=0.005 and P=0.041).The mean weight scores in group 3 were similar to those in group 2,but the scores in group 3 were signifi cantly lower than those in group 1(-1.75±1.05,-1.21±1.37 and-0.88±1.49,respectively).Conclusion:As the duration of exposure is prolonged in children with H.pylori infection,the negative effect of the infection on both height and weight is evident.
