Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population

AIM: To investigate features of Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) among a Mexican population.METHODS: Cases of primary gastric adenocarcinoma were retrieved from the files of the Departments of anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer. EBV-encoded small non-polyadenylated RNA-1 (EBER-1)in situ hybridization was conducted to determine the presence of EBV in neoplastic cells.RESULTS: We studied 330 consecutive, non-selected,primary gastric carcinomas. Among these, there were173 male and 157 female patients (male/female ratio1.1/1). EBER-1 was detected in 24 (7.3%) cases (male/female ratio: 1.2/1). The mean age for the entire group was 58.1 years (range: 20-88 years), whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years (range: 50-84 years). Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared. EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively.CONCLUSION: Among Latin-American countries, Mexico has the lowest frequency of EBVaGC. Indeed, the Mexican population ＞50 years of age was selectively affected. Ethnic variations are responsible for the epidemiologic behavior of EBVaGC among the worldwide population.

Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: Experience in a Mexican institution

瞄准：在墨西哥 ulcerative (UC ) 的一件样品估计流行和 p-ANCA 的临床的价值病人。方法：在一个未来的、同意 IRB 的协议， p-ANCA 与 UC 在 80 个病人被决定(吝啬的年龄， 32 +/- 12.9 年) 。疾病的严厉和延期被临床的方法决定，寻找有 p-ANCA 地位的一个统计协会。结果：p-ANCA 在 41 被检测(51%) 病人。疾病的严厉是统计上与他们的存在联系的唯一的临床的变量(P 【 0.0001；或 = 9；CI 95%= 3.2-24.7 ) 。结论：p-ANCA 的流行类似于在另外的国家报导了那。他们的存在被联系到 UC 严厉，但是比提供了没有更多的信息由临床的方法获得了。