<span style="font-family:Verdana;">Phytochemical analysis shows that mahkota dewa fruit contains polyphenols. Mahkota dewa polyphenols have the ability to disrupt or reverse the stages of cancer or a c...<span style="font-family:Verdana;">Phytochemical analysis shows that mahkota dewa fruit contains polyphenols. Mahkota dewa polyphenols have the ability to disrupt or reverse the stages of cancer or a carcinogenesis process by affecting the intracellular signaling tissue molecules involved in an initiation and/or promotion. This chemopreventive potential is highly anticipating. The use, effectiveness, and benefits of the polyphenol have been empirically and pre-clinically proved without side effects. A multivariate analysis using Spearman’s test was conducted to examine the correlation between variables. Meanwhile, to determine which dependent variables played the strong role, a discriminant function analysis was performed with a significance level of p < 0.05 and a reliability level of 95%. The results showed that the mahkota dewa polyphenols acted as the suppressor agent by inducing apoptosis. This finding proved that polyphenols addition might result in death signal transduction through an apoptosis pathway which is either mediated by death receptor or mitochondria. The results of this study indicate that there is a relationship between apoptotic cell death mediated by death receptor and mitochondria through the administration of mahkota dewa polyphenols, it can be argued that mahkota dewa polyphenols can function in lung cancer chemoprevention in mice strain Balb/c.</span>展开更多
Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease.The active compound of mangosteen fruit pericarps,α-mangostin,has been commonly used as traditional med...Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease.The active compound of mangosteen fruit pericarps,α-mangostin,has been commonly used as traditional medicine and dietary supplement.We examined the effect ofα-mangostin against dengue virus(DENV)infection in human peripheral blood mononuclear cells(PBMC)by the measurement of virus titer and TNF-αand IFN-γcytokines concentration post infection.Increasing concentration ofα-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24-and 48-h post infection.Our results support the potential use ofα-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.展开更多
文摘<span style="font-family:Verdana;">Phytochemical analysis shows that mahkota dewa fruit contains polyphenols. Mahkota dewa polyphenols have the ability to disrupt or reverse the stages of cancer or a carcinogenesis process by affecting the intracellular signaling tissue molecules involved in an initiation and/or promotion. This chemopreventive potential is highly anticipating. The use, effectiveness, and benefits of the polyphenol have been empirically and pre-clinically proved without side effects. A multivariate analysis using Spearman’s test was conducted to examine the correlation between variables. Meanwhile, to determine which dependent variables played the strong role, a discriminant function analysis was performed with a significance level of p < 0.05 and a reliability level of 95%. The results showed that the mahkota dewa polyphenols acted as the suppressor agent by inducing apoptosis. This finding proved that polyphenols addition might result in death signal transduction through an apoptosis pathway which is either mediated by death receptor or mitochondria. The results of this study indicate that there is a relationship between apoptotic cell death mediated by death receptor and mitochondria through the administration of mahkota dewa polyphenols, it can be argued that mahkota dewa polyphenols can function in lung cancer chemoprevention in mice strain Balb/c.</span>
文摘Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease.The active compound of mangosteen fruit pericarps,α-mangostin,has been commonly used as traditional medicine and dietary supplement.We examined the effect ofα-mangostin against dengue virus(DENV)infection in human peripheral blood mononuclear cells(PBMC)by the measurement of virus titer and TNF-αand IFN-γcytokines concentration post infection.Increasing concentration ofα-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24-and 48-h post infection.Our results support the potential use ofα-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.
