Background Antimicrobial resistance(AMR)in livestock and the environment likely contribute to the prevalence of AMR in humans with potential detrimental effects on human health.As such,annual mandatory monitoring of A...Background Antimicrobial resistance(AMR)in livestock and the environment likely contribute to the prevalence of AMR in humans with potential detrimental effects on human health.As such,annual mandatory monitoring of AMR in livestock occurs within the European Union(EU),according to harmonised methods.Extended-spectrum cephalosporins-resistant(ESC-resistant)Escherichia coli,including extended-spectrumβ-lactamases(ESBL),AmpCβ-lactamases(AmpC)and carbapenemase producing E.coli,are considered of particular importance and are therefore included in the monitoring program.Methods Using results from the annual monitoring of ESC-resistant E.coli from 2014-2022,trends in prevalence per animal sector were determined over the complete time period,as well as potential seasonal effects.Results During these nine years,significant changes were observed in the prevalence of ESC-resistant E.coli,in broilers,dairy cattle and veal calves,while no changes in prevalence were seen in slaughter pigs.Furthermore,the prevalence of ESC-resistant E.coli is positively correlated with warmer seasons(summer and autumn)for both dairy cattle and veal calves,while no associations were found for broilers and slaughter pigs.While temperature itself may play a role in the prevalence of ESC-resistant E.coli,other factors affecting the selective landscape,such as antibiotic usage,will also play a role.Conclusion A combined analysis of antimicrobial usage and prevalence of ESC-resistant E.coli through the year,both in livestock and human samples,would be an interesting follow-up of this study.展开更多
基金funding from the Ministry of Agriculture,Nature and Food Quality in the Netherlands(grant number WOT-01-002-03.02)the Medical Research Council(MRC),Biotechnology and Biological Sciences Research Council(BBSRC)+1 种基金Natural Environmental Research Council(NERC),which are all councils of UK Research and Innovation(grant number MR/W030578/1)from ZonMw(grant number 10570132110004)under the umbrella of the JPIAMR(Joint Programming Initiative on Antimicrobial Resistance)project STRESST.
文摘Background Antimicrobial resistance(AMR)in livestock and the environment likely contribute to the prevalence of AMR in humans with potential detrimental effects on human health.As such,annual mandatory monitoring of AMR in livestock occurs within the European Union(EU),according to harmonised methods.Extended-spectrum cephalosporins-resistant(ESC-resistant)Escherichia coli,including extended-spectrumβ-lactamases(ESBL),AmpCβ-lactamases(AmpC)and carbapenemase producing E.coli,are considered of particular importance and are therefore included in the monitoring program.Methods Using results from the annual monitoring of ESC-resistant E.coli from 2014-2022,trends in prevalence per animal sector were determined over the complete time period,as well as potential seasonal effects.Results During these nine years,significant changes were observed in the prevalence of ESC-resistant E.coli,in broilers,dairy cattle and veal calves,while no changes in prevalence were seen in slaughter pigs.Furthermore,the prevalence of ESC-resistant E.coli is positively correlated with warmer seasons(summer and autumn)for both dairy cattle and veal calves,while no associations were found for broilers and slaughter pigs.While temperature itself may play a role in the prevalence of ESC-resistant E.coli,other factors affecting the selective landscape,such as antibiotic usage,will also play a role.Conclusion A combined analysis of antimicrobial usage and prevalence of ESC-resistant E.coli through the year,both in livestock and human samples,would be an interesting follow-up of this study.
