Hammerhead ribozymes are small RNA moleculesthat bind to a complementary sequence of RNA andcleave that sequence at a conserved triplet NUX (N =G, A, X = A, U, C). ln comparison with ilntisensemolecuIes, ribozymes not...Hammerhead ribozymes are small RNA moleculesthat bind to a complementary sequence of RNA andcleave that sequence at a conserved triplet NUX (N =G, A, X = A, U, C). ln comparison with ilntisensemolecuIes, ribozymes not only bind to target RNA butalso cleave the target at predicted sites. They havebeen used as molecular agents to destroy either viralRNA or oncogene transcripts in human cancers. Manyhuman cervical and oral carcinomas express RNA展开更多
Gene therapy of human cancer is likely to bemost effective when it is directed at targets that areexpressed in cancer cells but are lacking from othercells. Human papillomaviruses (HPV) can providesuch target, since t...Gene therapy of human cancer is likely to bemost effective when it is directed at targets that areexpressed in cancer cells but are lacking from othercells. Human papillomaviruses (HPV) can providesuch target, since these viruses are present in manycervical and oral cancers, and likely to be etiologicagents of the tumor. The oncogenic ability of HPVhas been assigned primarily to its two early genes, E6and E7. Continued expression of these two genes展开更多
文摘Hammerhead ribozymes are small RNA moleculesthat bind to a complementary sequence of RNA andcleave that sequence at a conserved triplet NUX (N =G, A, X = A, U, C). ln comparison with ilntisensemolecuIes, ribozymes not only bind to target RNA butalso cleave the target at predicted sites. They havebeen used as molecular agents to destroy either viralRNA or oncogene transcripts in human cancers. Manyhuman cervical and oral carcinomas express RNA
文摘Gene therapy of human cancer is likely to bemost effective when it is directed at targets that areexpressed in cancer cells but are lacking from othercells. Human papillomaviruses (HPV) can providesuch target, since these viruses are present in manycervical and oral cancers, and likely to be etiologicagents of the tumor. The oncogenic ability of HPVhas been assigned primarily to its two early genes, E6and E7. Continued expression of these two genes
