Purpose: To investigate whether type of glaucoma or use of acetazolamide are a ssociated with main cause of death and comorbidity. Material and Methods: The su rvival data, including date and cause of death, for 1147 ...Purpose: To investigate whether type of glaucoma or use of acetazolamide are a ssociated with main cause of death and comorbidity. Material and Methods: The su rvival data, including date and cause of death, for 1147 patients with capsular or simple glaucoma who were ultimately hospitalized at the Eye Department, Natio nal Hospital, Oslo, between 1961 and 1970, were analysed. Binary logistic regres sion was carried out to investigate the patterns of death causes and comorbidity in subgroup analyses. Results: Patients with exfoliative glaucoma (XFG) and tho se with primary open-angle glaucoma (POAG)-showed no significant differences i n rates of death caused by acute cerebrovascular diseases, cardiac diseases and cancer. Interestingly, we found that chronic cerebral diseases such as senile de mentia, cerebral atrophy and chronic cerebral ischaemia (n=81) were more common in patients with XFG than in those with POAG(P=0.01) and in the group of acetazo lamide users (P=0.03). Patients with XFG had a higher probability of developing an acute cerebrovascular disease than patients with POAG (n=228, P=0.03). Conclu sion: In this retrospective study, we found that comorbidity with acute cerebrov ascular disease and chronic cerebral diseases (senile dementia, cerebral atrophy and chronic cerebral ischaemia) were more common in patients with XFG than in p atients with POAG. Prospective data are needed in order to conclude upon the ass ociations found in this study.展开更多
Purpose: To compare the survival rates of patients with exfoliative glaucoma ( XFG) and those with primary open-angle glaucoma (POAG), and to establish whethe r the use of acetazolamide has any influence on survival. ...Purpose: To compare the survival rates of patients with exfoliative glaucoma ( XFG) and those with primary open-angle glaucoma (POAG), and to establish whethe r the use of acetazolamide has any influence on survival. Methods: The survival data, including date and cause of death, for 1147 patients with XFG or POAG who were ultimately hospitalized at the Eye Department, National Hospital, Oslo, bet ween 1961 and 1970, were analysed retrospectively. The Cox proportional hazard m odel was used in the survival analyses. Results: No statistically significant di fferences in survival were found between patients with XFG and those with POAG ( P=0.85). As expected, female gender and younger age at diagnosis were associated with longer survival periods. Surprisingly, we found that patients with more re cent birth dates had relatively lower survival rates than patients with earlier birth dates; when this was included in the analyses, the use of acetazolamide wa s found to be associated with reduced survival (n=492, P=0.02).展开更多
文摘Purpose: To investigate whether type of glaucoma or use of acetazolamide are a ssociated with main cause of death and comorbidity. Material and Methods: The su rvival data, including date and cause of death, for 1147 patients with capsular or simple glaucoma who were ultimately hospitalized at the Eye Department, Natio nal Hospital, Oslo, between 1961 and 1970, were analysed. Binary logistic regres sion was carried out to investigate the patterns of death causes and comorbidity in subgroup analyses. Results: Patients with exfoliative glaucoma (XFG) and tho se with primary open-angle glaucoma (POAG)-showed no significant differences i n rates of death caused by acute cerebrovascular diseases, cardiac diseases and cancer. Interestingly, we found that chronic cerebral diseases such as senile de mentia, cerebral atrophy and chronic cerebral ischaemia (n=81) were more common in patients with XFG than in those with POAG(P=0.01) and in the group of acetazo lamide users (P=0.03). Patients with XFG had a higher probability of developing an acute cerebrovascular disease than patients with POAG (n=228, P=0.03). Conclu sion: In this retrospective study, we found that comorbidity with acute cerebrov ascular disease and chronic cerebral diseases (senile dementia, cerebral atrophy and chronic cerebral ischaemia) were more common in patients with XFG than in p atients with POAG. Prospective data are needed in order to conclude upon the ass ociations found in this study.
文摘Purpose: To compare the survival rates of patients with exfoliative glaucoma ( XFG) and those with primary open-angle glaucoma (POAG), and to establish whethe r the use of acetazolamide has any influence on survival. Methods: The survival data, including date and cause of death, for 1147 patients with XFG or POAG who were ultimately hospitalized at the Eye Department, National Hospital, Oslo, bet ween 1961 and 1970, were analysed retrospectively. The Cox proportional hazard m odel was used in the survival analyses. Results: No statistically significant di fferences in survival were found between patients with XFG and those with POAG ( P=0.85). As expected, female gender and younger age at diagnosis were associated with longer survival periods. Surprisingly, we found that patients with more re cent birth dates had relatively lower survival rates than patients with earlier birth dates; when this was included in the analyses, the use of acetazolamide wa s found to be associated with reduced survival (n=492, P=0.02).
