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Acute myocardial infarction and sub-acute stent thrombosis associated with occult essential thrombocythemia 被引量:2
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作者 Zafer Isilak Mehmet Tezcan +1 位作者 Murat Atalay ejder kardesoglu 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第19期3512-3513,共2页
70-year-old female with no Aprevious cardiac history resented with complaints of severe chest and back pain lasting for 20 minutes. She had a past history of type 2 diabetes mellitus for five years and hypertension fo... 70-year-old female with no Aprevious cardiac history resented with complaints of severe chest and back pain lasting for 20 minutes. She had a past history of type 2 diabetes mellitus for five years and hypertension for twenty years, but denied a history of hyperlipidemia, smoking or hemorrhagic disorder. There was no family history of coronary artery or hematologic disease. On physical examination, the blood pressure was 145/90 mmHg and the heart rate was 102 beats/rain. Cardiac examination revealed normal S1 and $2 sounds. There were no murmors or clicks. The lungs were clear on auscultation. Hepatosplenomegaly or lymphadenopathy was not detected. Her electrocardiogram showed ST elevations in lead V1-V6, consistent with acute anterior MI and echocardiogram supported the diagnosis with a slight reduction in wall motion in the anterior region. Complete blood count revealed a white blood cell count of 9 000/mm3 with a normal differential, red blood cell count of 3.5×106/mm3, hematocrit of 40.2%, and platelet count of 238 000/mm3. Emergent coronary angiography demonstrated proximal thrombotic occlusion of the left anterior descending artery (LAD) (Figure 1A). A loading dose of 600 mg clopidogrel and 300 mg acetylsalicylic asid (ASA) was given immediately. After administration of 10 000 U intravenous heparin, angioplasty was performed and a 3.0 mm×20.0 mm bare metal stent (BMS) was deployed to the LAD. Repeat angiogram revealed TIMI III flow in the LAD (Figure 1B). Five days later, the patient was discharged without any bleeding or thrombotic complications. She was receiving dual antiplatelet therapy with ASA and clopidogrel 150 mg daily. However, she was admitted to our hospital again with severe chest pain just one day after dischargement. Her platelet count of 487 000/mm3 was remarkable in comparison with her previous complete blood count. Electrocardiogram showed ST elevations in leads V1-V6, suggestive of an acute anterior reinfarction. Coronary angiography revealed in- stent thrombosis in the LAD (Figure 1C). After balloon angioplasty (Figure 1D), TIMI III flow was achieved and no residual stenosis was seen. During her follow-up, complete blood cell counts showed gradually increasing platelets up to 818 000/ram3, on the fourth day of sub- acute stent thrombosis. Peripheral blood smear examination was performed and showed markedly increased large thrombocytes with anisothrombia, consistent with essential thrombocythemia (ET). Soon after, platelet-loweringtherapy with hydroxyurea (500 mg/d) was initiated, One week after the initiation of hydroxyurea, the platelet count was decreased to 220 000/ram3. The patient remained on hydroxyurea and dual antiplatelet therapy. She was free of symptoms for three months during the follow-up period and her platelet counts remained within the normal range. 展开更多
关键词 acute myocardial infarction essential thromboeythemia sub-acute stent thrombosis
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Inhibition of vascular smooth muscle cell proliferation: an indispensable target in treatment
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作者 ejder kardesoglu Murat Yalcin +2 位作者 Zafer lsilak Omer Uz Murat Atalay 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第19期3600-3600,共1页
To the Editor: We carefully read with interest an original article by Wang et al,^1 entitled "Different effects of telmisartan andvalsartan on human aortic vascular smooth muscle cell proliferation", published in a... To the Editor: We carefully read with interest an original article by Wang et al,^1 entitled "Different effects of telmisartan andvalsartan on human aortic vascular smooth muscle cell proliferation", published in a recent issue of the Chinese Medical Journal. In this study, the effects of angiotensin receptor blokers (ARBs) including telmisartan and valsartan on human aortic vascular smooth muscle cell proliferation (VSMC) in cell culture were investigated and compared. Telmisartan was shown to inhibit the VSMC proliferation even without stimulation of angiotensin Ⅱ (Ang Ⅱ). 展开更多
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