Background:Persistent organic pollutants(POPs)are subject of particular attention and in-depth studies which demonstrate their toxicity towards humans and biotope in general.POPs are therefore addressed by the Stockho...Background:Persistent organic pollutants(POPs)are subject of particular attention and in-depth studies which demonstrate their toxicity towards humans and biotope in general.POPs are therefore addressed by the Stockholm Convention globally with human milk or blood as matrix for effectiveness evaluation.Objectives:The objective of this study was to assess plasma concentrations of certain chlorinated POPs in subjects from the urban population in Algiers.Methods:A total number of 207 adult subjects were recruited in Algiers and plasma concentrations of Hexachlorobenzene(HCB),p,p’Dichlorodiphenyl DichloroEthylene(4,40 DDE)and Polychlorinated Biphenyls(PCBs)were determined by gas chromatography with mass spectrometry detection(GC-MS).Results:The nanogram per gram of lipids(ng g^(-1) lipids)geometric means of plasma concentrations of studied compounds were:6.09 for HCB,131.60 for 4,40 DDE,8.61 for PCB153,7.95 for PCB138 and 8.39 for PCB180.PCB 180,PCB 153 and PCB 138 showed a high correlation with each other(r>0.5).4,40 DDE concentrations were significantly higher in women and in subject with low educational level,whereas POPs were higher in older participants(>65 years old).Organochlorine pesticides(OCPs)and PCB153 concentrations were higher in overweight and obese subjects.There was no significant difference between POPs concentrations according to breastfeeding history,smoking status or fish consumption.Conclusions:Chlorinated POPs were detected in the blood plasma of adults living in Algiers.Plasma concentrations were consistent with those of several studies in the world.However,further investigations are needed to assess the exposure profile of subjects living near contaminated sites.展开更多
文摘Background:Persistent organic pollutants(POPs)are subject of particular attention and in-depth studies which demonstrate their toxicity towards humans and biotope in general.POPs are therefore addressed by the Stockholm Convention globally with human milk or blood as matrix for effectiveness evaluation.Objectives:The objective of this study was to assess plasma concentrations of certain chlorinated POPs in subjects from the urban population in Algiers.Methods:A total number of 207 adult subjects were recruited in Algiers and plasma concentrations of Hexachlorobenzene(HCB),p,p’Dichlorodiphenyl DichloroEthylene(4,40 DDE)and Polychlorinated Biphenyls(PCBs)were determined by gas chromatography with mass spectrometry detection(GC-MS).Results:The nanogram per gram of lipids(ng g^(-1) lipids)geometric means of plasma concentrations of studied compounds were:6.09 for HCB,131.60 for 4,40 DDE,8.61 for PCB153,7.95 for PCB138 and 8.39 for PCB180.PCB 180,PCB 153 and PCB 138 showed a high correlation with each other(r>0.5).4,40 DDE concentrations were significantly higher in women and in subject with low educational level,whereas POPs were higher in older participants(>65 years old).Organochlorine pesticides(OCPs)and PCB153 concentrations were higher in overweight and obese subjects.There was no significant difference between POPs concentrations according to breastfeeding history,smoking status or fish consumption.Conclusions:Chlorinated POPs were detected in the blood plasma of adults living in Algiers.Plasma concentrations were consistent with those of several studies in the world.However,further investigations are needed to assess the exposure profile of subjects living near contaminated sites.
