The combination of electrophysiology and optogenetics enables the exploration of how the brain operates down to a single neuron and its network activity.Neural probes are in vivo invasive devices that integrate sensor...The combination of electrophysiology and optogenetics enables the exploration of how the brain operates down to a single neuron and its network activity.Neural probes are in vivo invasive devices that integrate sensors and stimulation sites to record and manipulate neuronal activity with high spatiotemporal resolution.State-of-the-art probes are limited by tradeoffs involving their lateral dimension,number of sensors,and ability to access independent stimulation sites.Here,we realize a highly scalable probe that features three-dimensional integration of small-footprint arrays of sensors and nanophotonic circuits to scale the density of sensors per cross-section by one order of magnitude with respect to state-of-the-art devices.For the first time,we overcome the spatial limit of the nanophotonic circuit by coupling only one waveguide to numerous optical ring resonators as passive nanophotonic switches.With this strategy,we achieve accurate on-demand light localization while avoiding spatially demanding bundles of waveguides and demonstrate the feasibility with a proof-of-concept device and its scalability towards high-resolution and low-damage neural optoelectrodes.展开更多
文摘The combination of electrophysiology and optogenetics enables the exploration of how the brain operates down to a single neuron and its network activity.Neural probes are in vivo invasive devices that integrate sensors and stimulation sites to record and manipulate neuronal activity with high spatiotemporal resolution.State-of-the-art probes are limited by tradeoffs involving their lateral dimension,number of sensors,and ability to access independent stimulation sites.Here,we realize a highly scalable probe that features three-dimensional integration of small-footprint arrays of sensors and nanophotonic circuits to scale the density of sensors per cross-section by one order of magnitude with respect to state-of-the-art devices.For the first time,we overcome the spatial limit of the nanophotonic circuit by coupling only one waveguide to numerous optical ring resonators as passive nanophotonic switches.With this strategy,we achieve accurate on-demand light localization while avoiding spatially demanding bundles of waveguides and demonstrate the feasibility with a proof-of-concept device and its scalability towards high-resolution and low-damage neural optoelectrodes.
