Introduction. Many cutaneous complications have been reported in patients treated with cyclosporine. Alterations of the pilosebaceous follicle are particularly frequent. Hypertrichosis, follicular keratosis, acne and ...Introduction. Many cutaneous complications have been reported in patients treated with cyclosporine. Alterations of the pilosebaceous follicle are particularly frequent. Hypertrichosis, follicular keratosis, acne and folliculitis are very common. Nevertheless,theoccurrenceofsebaceoushyperplasiaisexceptional. Observation. A 27 year- old man consulted in February 2003 for a papulous eruption of the face. He was treated by cyclosporine and prednisone since his renal transplantation in 1993. The lesions flowed together on the cheeks, forehead and temples. The histological analysis confirmed the diagnosis of sebaceous hyperplasia. There was a perceptible improvement of the cutaneous state after one month of isotretinoin treatment. Discussion. Sebaceous hyperplasia appears in about 10 p. 100 of patients treated with cyclosporine. This side effect occurs only in men of a mean age of 40 years. An increase in sebaceous gland size is often described, but profuse forms are uncommon. Our case report is exceptional because of the young age of the patient, and the occurrence of diffuse sebaceous hyperplasia that appeared a long time after the introduction of cyclosporine.展开更多
We report two patients with orthotopic liver transplantation (OLT) who develop ed a syndrome that fulfilled criteria for definite chronic inflammatory demyelin ating polyradiculoneuropathy (CIDP). One patient had OLT ...We report two patients with orthotopic liver transplantation (OLT) who develop ed a syndrome that fulfilled criteria for definite chronic inflammatory demyelin ating polyradiculoneuropathy (CIDP). One patient had OLT because of alcoholic ci rrhosis and one following hepatitis C induced hepatic failure. Both had immunos uppressive therapy, with cyclosporine and prednisolone in one case and tacrolimu s in the other case. Treatment with intravenous immune globulin (IVIG) significa ntly improved the neuropathy in both patients. In patients with OLT developing d isabling sensorimotor neuropathies, CIDP should be considered as should the use of potentially beneficial immunosuppressive treatment.展开更多
文摘Introduction. Many cutaneous complications have been reported in patients treated with cyclosporine. Alterations of the pilosebaceous follicle are particularly frequent. Hypertrichosis, follicular keratosis, acne and folliculitis are very common. Nevertheless,theoccurrenceofsebaceoushyperplasiaisexceptional. Observation. A 27 year- old man consulted in February 2003 for a papulous eruption of the face. He was treated by cyclosporine and prednisone since his renal transplantation in 1993. The lesions flowed together on the cheeks, forehead and temples. The histological analysis confirmed the diagnosis of sebaceous hyperplasia. There was a perceptible improvement of the cutaneous state after one month of isotretinoin treatment. Discussion. Sebaceous hyperplasia appears in about 10 p. 100 of patients treated with cyclosporine. This side effect occurs only in men of a mean age of 40 years. An increase in sebaceous gland size is often described, but profuse forms are uncommon. Our case report is exceptional because of the young age of the patient, and the occurrence of diffuse sebaceous hyperplasia that appeared a long time after the introduction of cyclosporine.
文摘We report two patients with orthotopic liver transplantation (OLT) who develop ed a syndrome that fulfilled criteria for definite chronic inflammatory demyelin ating polyradiculoneuropathy (CIDP). One patient had OLT because of alcoholic ci rrhosis and one following hepatitis C induced hepatic failure. Both had immunos uppressive therapy, with cyclosporine and prednisolone in one case and tacrolimu s in the other case. Treatment with intravenous immune globulin (IVIG) significa ntly improved the neuropathy in both patients. In patients with OLT developing d isabling sensorimotor neuropathies, CIDP should be considered as should the use of potentially beneficial immunosuppressive treatment.
