To develope two simple and accurate spectrophotometric methods for the determination of meloxicam( I )in presence of its degradation products, 5 -methyl -2 -aminothiazole ( II )and benzothiazine carboxylic acid( Ill )...To develope two simple and accurate spectrophotometric methods for the determination of meloxicam( I )in presence of its degradation products, 5 -methyl -2 -aminothiazole ( II )and benzothiazine carboxylic acid( Ill ). Method:Both methods are based on the formation of chelate complexes of the studied drug with uranyl acetate and ferric chloride at room temperature in a methanolic medium. Results:The resulting complexes are stable for 24 hrs and show absorption maxima at 406 nm and 580 nm for uranyl and ferric complexes respectively. These methods are applicable over the concentration ranges of 10 -100 and 37.5 -300 p^g ~ mL-1 with mean recoveries of (99.44 ~ 0. 48 ) % and (99. 42 ~ 0. 45 ) %, and molar absorptivity of 4.67 x 103 and 1. 029 x 103 respectively. Conclusion:Both methods are proved to be stability indicating as no interference was observed with the degradation products. The proposed methods were successfully applied to the determination of the frug in bulk powder, laboratory prepared mixtures containing different percentages of degradation products of the drug in bulk powand pharmaceutical dosage展开更多
文摘To develope two simple and accurate spectrophotometric methods for the determination of meloxicam( I )in presence of its degradation products, 5 -methyl -2 -aminothiazole ( II )and benzothiazine carboxylic acid( Ill ). Method:Both methods are based on the formation of chelate complexes of the studied drug with uranyl acetate and ferric chloride at room temperature in a methanolic medium. Results:The resulting complexes are stable for 24 hrs and show absorption maxima at 406 nm and 580 nm for uranyl and ferric complexes respectively. These methods are applicable over the concentration ranges of 10 -100 and 37.5 -300 p^g ~ mL-1 with mean recoveries of (99.44 ~ 0. 48 ) % and (99. 42 ~ 0. 45 ) %, and molar absorptivity of 4.67 x 103 and 1. 029 x 103 respectively. Conclusion:Both methods are proved to be stability indicating as no interference was observed with the degradation products. The proposed methods were successfully applied to the determination of the frug in bulk powder, laboratory prepared mixtures containing different percentages of degradation products of the drug in bulk powand pharmaceutical dosage
