Background It has been reported that the mitochondrial respiratory dysfunction(MRD)is important mechanisms affecting the heart failure(HF)pathogenesis.We sought to evaluate the potential role of MRD of peripheral bloo...Background It has been reported that the mitochondrial respiratory dysfunction(MRD)is important mechanisms affecting the heart failure(HF)pathogenesis.We sought to evaluate the potential role of MRD of peripheral blood mononuclear cells(PBMC)in severity prediction in patients with cardioverter-defibrillator implantation indications.HF Methods In this single-center study patients with HF of New York Heart Association(NYHA)Ⅰ-Ⅲ functional class(FC)and ca-rdioverter-defibrillator implantation indications underwent transthoracic echocardiography(TTE)and MRD assessment using PB-MC.Mitochondrial respiration rate(MRR)indicators(pyruvate+malate+adenosine diphosphate;succinate+adenosine diphos-phate;pyruvate+malate–adenosine diphosphate[V_(4.1)];succinate–adenosine diphosphate)were calculated.Correlations betwe-en HF NYHA FC,TTE and MRR indicators were evaluated.Based on our data,we developed a risk model regarding HF severi-ty.Results Of 53(100.0%)HF patients,33(62.3%)had mild exercise intolerance(1^(st) group)and 20(37.7%)had moderate-to-severe ex-ercise intolerance(2^(nd) group).Patients with mild exercise intolerance were likely to have a higher V_(4.1)(P<0.001)values.V_(4.1) was ind-ependently associated with moderate-to-severe exercise intolerance in univariate and multivariate logistic regression(OR=0.932,CI:0.891–0.975,P<0.001).95%Conclusions The severity of HF is associated with PBMC mitochondrial respiratory dysfunction in patients with cardioverter-de-fibrillator implantation indications.Our HF severity risk model including V_(4.1) parameters is able to distinguish patients with mild and moderate-to-severe exercise intolerance.Further investigations of their predictive significance are warranted.展开更多
文摘Background It has been reported that the mitochondrial respiratory dysfunction(MRD)is important mechanisms affecting the heart failure(HF)pathogenesis.We sought to evaluate the potential role of MRD of peripheral blood mononuclear cells(PBMC)in severity prediction in patients with cardioverter-defibrillator implantation indications.HF Methods In this single-center study patients with HF of New York Heart Association(NYHA)Ⅰ-Ⅲ functional class(FC)and ca-rdioverter-defibrillator implantation indications underwent transthoracic echocardiography(TTE)and MRD assessment using PB-MC.Mitochondrial respiration rate(MRR)indicators(pyruvate+malate+adenosine diphosphate;succinate+adenosine diphos-phate;pyruvate+malate–adenosine diphosphate[V_(4.1)];succinate–adenosine diphosphate)were calculated.Correlations betwe-en HF NYHA FC,TTE and MRR indicators were evaluated.Based on our data,we developed a risk model regarding HF severi-ty.Results Of 53(100.0%)HF patients,33(62.3%)had mild exercise intolerance(1^(st) group)and 20(37.7%)had moderate-to-severe ex-ercise intolerance(2^(nd) group).Patients with mild exercise intolerance were likely to have a higher V_(4.1)(P<0.001)values.V_(4.1) was ind-ependently associated with moderate-to-severe exercise intolerance in univariate and multivariate logistic regression(OR=0.932,CI:0.891–0.975,P<0.001).95%Conclusions The severity of HF is associated with PBMC mitochondrial respiratory dysfunction in patients with cardioverter-de-fibrillator implantation indications.Our HF severity risk model including V_(4.1) parameters is able to distinguish patients with mild and moderate-to-severe exercise intolerance.Further investigations of their predictive significance are warranted.
