A novel Schiff base, benzylmethyl-4-methyl-3-thiosemicarbazone (BMM) de-rived from benzylmethylketone and 4-methylthiosemicarbazide was synthe-sized and characterized by elemental analysis, spectroscopic methods (IR, ...A novel Schiff base, benzylmethyl-4-methyl-3-thiosemicarbazone (BMM) de-rived from benzylmethylketone and 4-methylthiosemicarbazide was synthe-sized and characterized by elemental analysis, spectroscopic methods (IR, 1H NMR, 13C NMR) and physical means. The single crystal structure analysis of the Schiff base reveals that it crystallizes in a monoclinic system in the P21/c space group. BMM revealed moderate antibacterial activity on three bacterial strains with diameter zone of inhibition of 16 mm (E. coli), 14 mm (K. pneumonia) and 13 mm (S. epider-midis) compared with the standard drug, ciprofloxacin.展开更多
文摘A novel Schiff base, benzylmethyl-4-methyl-3-thiosemicarbazone (BMM) de-rived from benzylmethylketone and 4-methylthiosemicarbazide was synthe-sized and characterized by elemental analysis, spectroscopic methods (IR, 1H NMR, 13C NMR) and physical means. The single crystal structure analysis of the Schiff base reveals that it crystallizes in a monoclinic system in the P21/c space group. BMM revealed moderate antibacterial activity on three bacterial strains with diameter zone of inhibition of 16 mm (E. coli), 14 mm (K. pneumonia) and 13 mm (S. epider-midis) compared with the standard drug, ciprofloxacin.
