The effects of two chlorinated chiral stationary phases, namely, Lux Cellulose-2 and Lux i-Cellulose-5, flow-rate, percentage of co-solvent and chemical structures of the compounds on retention and resolution were stu...The effects of two chlorinated chiral stationary phases, namely, Lux Cellulose-2 and Lux i-Cellulose-5, flow-rate, percentage of co-solvent and chemical structures of the compounds on retention and resolution were studied within this article. In this work a backpressure of 150 bar, a temperature of 40 ℃ and 10% of methanol as co-solvent were chosen as operating conditions. The optimum flow-rate was 2 mL/min. The percentage of co-solvent was studied between 7.5% and 15%.We have observed that 15% of methanol gave the best results for most of the compounds. For all the derivatives, the Lux Cellulose-2 provided better resolutions going from 1.50 to 3.59 compared with Lux i-Cellulose-5.展开更多
The first International Symposium on Advances in Pharmaceutical Analysis (APA 2017) was started and held successfully in Wuhan University, China from November 17 to 19, 2017. The organization of the 2nd International ...The first International Symposium on Advances in Pharmaceutical Analysis (APA 2017) was started and held successfully in Wuhan University, China from November 17 to 19, 2017. The organization of the 2nd International Symposium on Advances in Pharmaceutical Analysis in the capital city of Flanders, Lille, was both an exciting and challenging project because the idea of an annual meeting between our two long cooperating Schools of Pharmaceutical Sciences of Wuhan and Lille, stood to reason.展开更多
基金supported by the State as part of the "Programme d’Investissement d’Avenir",under reference ANR10-IEED-0004-01
文摘The effects of two chlorinated chiral stationary phases, namely, Lux Cellulose-2 and Lux i-Cellulose-5, flow-rate, percentage of co-solvent and chemical structures of the compounds on retention and resolution were studied within this article. In this work a backpressure of 150 bar, a temperature of 40 ℃ and 10% of methanol as co-solvent were chosen as operating conditions. The optimum flow-rate was 2 mL/min. The percentage of co-solvent was studied between 7.5% and 15%.We have observed that 15% of methanol gave the best results for most of the compounds. For all the derivatives, the Lux Cellulose-2 provided better resolutions going from 1.50 to 3.59 compared with Lux i-Cellulose-5.
文摘The first International Symposium on Advances in Pharmaceutical Analysis (APA 2017) was started and held successfully in Wuhan University, China from November 17 to 19, 2017. The organization of the 2nd International Symposium on Advances in Pharmaceutical Analysis in the capital city of Flanders, Lille, was both an exciting and challenging project because the idea of an annual meeting between our two long cooperating Schools of Pharmaceutical Sciences of Wuhan and Lille, stood to reason.
