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Agnuside Reduces Visceral Adipocyte Size,Improves Insulin Sensitivity and Reverses Hepatic Steatosis in Ovariectomized Rats
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作者 Franciele Neves Moreno Eduardo Hideo Gilglioni +6 位作者 Rosangela Fernandes Garcia Naiara Cristina Lucredi Sandra Mara Ferreira Nilton Almeida Brito Marcia do Nascimento Brito emy luiza ishii-iwamoto Clairce Luzia Salgueiro-Pagadigorria 《Journal of Pharmacy and Pharmacology》 2019年第4期133-147,共15页
This study aimed to investigate the effects of agnuside(AGN),a phytoestrogen in Vitex agnus-castus,on cellular and metabolic alterations induced by ovariectomy in rats.Ovariectomized(OVX)Wistar rats were used as an an... This study aimed to investigate the effects of agnuside(AGN),a phytoestrogen in Vitex agnus-castus,on cellular and metabolic alterations induced by ovariectomy in rats.Ovariectomized(OVX)Wistar rats were used as an animal model of postmenopausal metabolic syndrome.The visceral and subcutaneous adipocyte sizes,the peripheral insulin sensitivity and the occurrence of nonalcoholic fatty liver disease(NAFLD)and liver oxidative damage were evaluated.The results were compared with those obtained from control rats(sham-operated)and OVX rats treated daily with AGN.Obese OVX rats exhibited visceral adipocyte hypertrophy and developed glucose intolerance,hyperinsulinemia,NAFLD and dyslipidemia.AGN exerted beneficial effects on several metabolic parameters in OVX rats,including the improvement in glucose intolerance,hyperinsulinemia and NAFLD.Besides,AGN promoted a general improvement in the liver redox state.Although the reduction of the mesenteric adipocyte size is very likely to be an important mode of action of AGN,some actions of AGN could also involve the interaction with estrogen receptors. 展开更多
关键词 METABOLIC syndrome OVARIECTOMIZED rats ADIPOCYTE size NAFLD agnuside
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Tibolone Reverses NAFLD in Ovariectomised Rats by Reducing Adiposity and Insulin Resistance
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作者 Lilian Brites Campos-Shimada Eduardo Hideo Gilglioni +5 位作者 Danielle Aparecida Munhos Hermoso Ana Julia dos Reis Buzzo Rosangela Fernandes Garcia Elismari Rizato Martins-Maciel emy luiza ishii-iwamoto Clairce Luzia Salgueiro-Pagadigorria 《Journal of Pharmacy and Pharmacology》 2019年第4期148-164,共17页
This study aimed to investigate the effects of tibolone,a synthetic steroid,on several metabolic dysfunctions induced by oestrogen deficiency,in rats.Ovariectomised(OVX)rats were used as animal model of postmenopausal... This study aimed to investigate the effects of tibolone,a synthetic steroid,on several metabolic dysfunctions induced by oestrogen deficiency,in rats.Ovariectomised(OVX)rats were used as animal model of postmenopausal metabolic syndrome.The OVX rats were treated with daily doses of tibolone(0.16 mg/kg)and the results were compared with control(sham-operated)and OVX untreated rats.Tibolone reduced the adiposity and the visceral adipocyte size in OVX rats.The insulin sensitivity was also improved,and a decrease in the activity of the adipose tissue hormone-sensitive lipase enzyme was recorded.The lower lipolysis by visceral adipocytes,associated with the recovery of peroxisomalβ-oxidation by tibolone may have contributed to the reversion of NAFLD in treated OVX rats.The reduction of liver lipid contents resulted in a general improvement in the liver redox state.In addition,tibolone reduced the mitochondrial ROS generation and restored the activity of glucose-6-phosphate dehydrogenase.Tibolone also exerted antioxidant effects on inguinal adipose tissue.Tibolone exerted several beneficial effects on cellular and metabolic dysfunctions induced by ovariectomy in rats.One important mode of action of tibolone was the reduction of the visceral adipocyte size,corroborating the relationship between this one and the development and progression of several comorbidities associated with metabolic syndrome. 展开更多
关键词 TIBOLONE OVARIECTOMY hepatic STEATOSIS obesity OXIDATIVESTRESS
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