The incidence of cathartic colon has been increasing,but satisfactory treatments are still lacking.In order to study the pathological mechanisms of the disorder and identify effective treatment methods,researchers hav...The incidence of cathartic colon has been increasing,but satisfactory treatments are still lacking.In order to study the pathological mechanisms of the disorder and identify effective treatment methods,researchers have established different animal models of cathartic colon.This minireview briefly summarizes several common cathartic colon animal models,induced with anthraquinone laxatives such as rhubarb,total anthraquinone,rhein,and emodin,or induced with diphenylmethane laxatives such as phenolphthalein.The advantages and limitations of these models are evaluated and analyzed.We hope that this review will facilitate the selection of suitable models and improve relevant modeling methods.We anticipate the development of more convenient and stable models that can reflect the characteristics of cathartic colon in humans,and serve as useful tools for further studies.展开更多
便秘型肠易激综合征(irritable bowel syndrome with constipation,IBS-C)病因病机仍未被完全阐明,缺乏令人满意的治疗手段,临床发病率不断上升,常常给患者的生活造成不同程度的影响.本文总结了近年来中医(traditional Chinese medicine...便秘型肠易激综合征(irritable bowel syndrome with constipation,IBS-C)病因病机仍未被完全阐明,缺乏令人满意的治疗手段,临床发病率不断上升,常常给患者的生活造成不同程度的影响.本文总结了近年来中医(traditional Chinese medicine,TCM)对IBS-C的病因病机的认识和常用的有效的治疗方法,为进一步研究TCM对IBS-C的作用提供一定的参考.展开更多
基金Supported by Xinglin Scholar,Xinglin Young Talent Program,No.RC-2017-02-07Shanghai Three-year Action Plan for Accelerating the Development of Traditional Chinese Medicine,No.ZY(2018-2020)-CCCX-2002-01and Research Fund of Longhua Hospital,No.2018YM05.
文摘The incidence of cathartic colon has been increasing,but satisfactory treatments are still lacking.In order to study the pathological mechanisms of the disorder and identify effective treatment methods,researchers have established different animal models of cathartic colon.This minireview briefly summarizes several common cathartic colon animal models,induced with anthraquinone laxatives such as rhubarb,total anthraquinone,rhein,and emodin,or induced with diphenylmethane laxatives such as phenolphthalein.The advantages and limitations of these models are evaluated and analyzed.We hope that this review will facilitate the selection of suitable models and improve relevant modeling methods.We anticipate the development of more convenient and stable models that can reflect the characteristics of cathartic colon in humans,and serve as useful tools for further studies.
文摘便秘型肠易激综合征(irritable bowel syndrome with constipation,IBS-C)病因病机仍未被完全阐明,缺乏令人满意的治疗手段,临床发病率不断上升,常常给患者的生活造成不同程度的影响.本文总结了近年来中医(traditional Chinese medicine,TCM)对IBS-C的病因病机的认识和常用的有效的治疗方法,为进一步研究TCM对IBS-C的作用提供一定的参考.
