Exploration of natural sources for novel bioactive compounds has been an emerging field of medicine over the past decades,providing drugs or lead compounds of considerable therapeutic potential.This research has provi...Exploration of natural sources for novel bioactive compounds has been an emerging field of medicine over the past decades,providing drugs or lead compounds of considerable therapeutic potential.This research has provided exciting evidence on the isolation of microbe-derived metabolites having prospective biological activities.Mushrooms have been valued as traditional sources of natural bioactive compounds for many centuries and have been targeted as promising therapeutic agents.Many novel biologically active compounds have been reported as a result of research on medicinal mushrooms.In this review,we compile the information on bioactive structure-elucidated metabolites from macrofungi discovered over the last decade and highlight their unique chemical diversity and potential benefits to novel drug discovery.The main emphasis is on their anti-Alzheimer,antidiabetic,anti-malarial,anti-microbial,anti-oxidant,antitumor,anti-viral and hypocholesterolemic activities which are important medicinal targets in terms of drug discovery today.Moreover,the reader’s attention is brought to focus on mushroom products and food supplements available in the market with claimed biological activities and potential human health benefits.展开更多
基金This study was supported by the grant of the 1551 French-Thai cooperation PHC SIAM 2011(project 25587RA)and the Mae Fah Luang University funded grant“Taxonomy,Phylogeny and cultivation of Lentinus species in northern Thailand”(MFU/54101020048)this study was financially supported by the project“Value added products from basidiomycetes:Putting Thailand’s biodiversity to use”(BRN049/2553)by the National Research Council of Thailand(NRCT)to study medicinal fungi+1 种基金the National Research Council of Thailand(NRCT),project-Taxonomy,Phylogeny and cultivation of Lentinus species in northern Thailand(NRCT/55201020007)the Thailand Research Fund grant-Taxonomy,Phylogeny and biochemistry of Thai Basidiomycetes(BRG 5580009).The authors would also like to acknowledge University Malaya research grants:CG037-2013 Phylogeny,taxonomy,relationships and biotechnological potential of sooty moulds and RG203-12SUS Isolation and structural elucidation of antimicrobial compounds for saprophytic and endophytic fungi of Peninsular Malaysia through bioassay guided fractionation of secondary metabolites extract.
文摘Exploration of natural sources for novel bioactive compounds has been an emerging field of medicine over the past decades,providing drugs or lead compounds of considerable therapeutic potential.This research has provided exciting evidence on the isolation of microbe-derived metabolites having prospective biological activities.Mushrooms have been valued as traditional sources of natural bioactive compounds for many centuries and have been targeted as promising therapeutic agents.Many novel biologically active compounds have been reported as a result of research on medicinal mushrooms.In this review,we compile the information on bioactive structure-elucidated metabolites from macrofungi discovered over the last decade and highlight their unique chemical diversity and potential benefits to novel drug discovery.The main emphasis is on their anti-Alzheimer,antidiabetic,anti-malarial,anti-microbial,anti-oxidant,antitumor,anti-viral and hypocholesterolemic activities which are important medicinal targets in terms of drug discovery today.Moreover,the reader’s attention is brought to focus on mushroom products and food supplements available in the market with claimed biological activities and potential human health benefits.
