OBJECTIVE To investigate the relationship between body mass index (BMI) and lung cancer risk among men in urban Shanghai, China. METHODS Between January 1,1986 and September 30,1989, a total of 18,244 male residents o...OBJECTIVE To investigate the relationship between body mass index (BMI) and lung cancer risk among men in urban Shanghai, China. METHODS Between January 1,1986 and September 30,1989, a total of 18,244 male residents of urban Shanghai were recruited in the prospective cohort study. The eligible study subjects were those aged 45 to 64 years and without history of cancer. Through July 10^th, 2003 (17 years follow-up), 467 new cases of lung cancer were identified in the cohort. Cox regression models were used to estimate the adjusted relative risks (RRs) and 95% confidence intervals (Cls). RESULTS The risk of lung cancer decreased with increasing in BMI. After adjustment for some potential confounding factors, a relative risk of 0.6 (highest versus lowest quintile of BMI) was observed (P-trend =0.01). Stratified by smoking status, an inverse association of body mass index with lung cancer risk still existed among current smokers. There were too few cases of lung cancer to draw a valid result among men who never smoked. The results also showed that the association of BMI with the risk of lung adenocarcinoma was more apparent than with other histological subtypes. CONCLUSION An inverse association of BMI with lung cancer risk may exist among men in Shanghai.展开更多
OBJECTIVE To investigate the relationship between BMI, WHR and biliary tract cancers (CBT).METHODS A population-based case-control study was conducted in urban Shanghai from June 1, 1997 to May 31,2001 involving inter...OBJECTIVE To investigate the relationship between BMI, WHR and biliary tract cancers (CBT).METHODS A population-based case-control study was conducted in urban Shanghai from June 1, 1997 to May 31,2001 involving interviews with 627 new cases of biliary tract cancers aged 35 to 74 years and 959 frequency-matched population controls by gender and age in five-year groups. All subjects were interviewed in person by trained interviewers using a structured questionnaire. An unconditional logistic regression was performed to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS Obesity was associated with an increased risk of gallbladder cancer across adulthood at ages 20-29 and 30-39 in females. Compared with subjects in the lowest quartile of WHR, ORs for the highest quartile and P for trend for cancers of gallbladder and extrahepatic bile duct both reached significant levels among males and females.CONCLUSION Our observations in urban Shanghai suggested that obesity in early adult life may contribute to the risk of gallbladder cancer, and increased WHR may substantially elevated risk of cancers of the gallbladder and extrahepatic bile duct.展开更多
文摘OBJECTIVE To investigate the relationship between body mass index (BMI) and lung cancer risk among men in urban Shanghai, China. METHODS Between January 1,1986 and September 30,1989, a total of 18,244 male residents of urban Shanghai were recruited in the prospective cohort study. The eligible study subjects were those aged 45 to 64 years and without history of cancer. Through July 10^th, 2003 (17 years follow-up), 467 new cases of lung cancer were identified in the cohort. Cox regression models were used to estimate the adjusted relative risks (RRs) and 95% confidence intervals (Cls). RESULTS The risk of lung cancer decreased with increasing in BMI. After adjustment for some potential confounding factors, a relative risk of 0.6 (highest versus lowest quintile of BMI) was observed (P-trend =0.01). Stratified by smoking status, an inverse association of body mass index with lung cancer risk still existed among current smokers. There were too few cases of lung cancer to draw a valid result among men who never smoked. The results also showed that the association of BMI with the risk of lung adenocarcinoma was more apparent than with other histological subtypes. CONCLUSION An inverse association of BMI with lung cancer risk may exist among men in Shanghai.
文摘OBJECTIVE To investigate the relationship between BMI, WHR and biliary tract cancers (CBT).METHODS A population-based case-control study was conducted in urban Shanghai from June 1, 1997 to May 31,2001 involving interviews with 627 new cases of biliary tract cancers aged 35 to 74 years and 959 frequency-matched population controls by gender and age in five-year groups. All subjects were interviewed in person by trained interviewers using a structured questionnaire. An unconditional logistic regression was performed to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS Obesity was associated with an increased risk of gallbladder cancer across adulthood at ages 20-29 and 30-39 in females. Compared with subjects in the lowest quartile of WHR, ORs for the highest quartile and P for trend for cancers of gallbladder and extrahepatic bile duct both reached significant levels among males and females.CONCLUSION Our observations in urban Shanghai suggested that obesity in early adult life may contribute to the risk of gallbladder cancer, and increased WHR may substantially elevated risk of cancers of the gallbladder and extrahepatic bile duct.
