Proteins are key players in various cellular processes.As the ultimate executors of cellular processes,they play essential roles in linking genotypes to phenotypes.Abnormalities in protein expression and post-translat...Proteins are key players in various cellular processes.As the ultimate executors of cellular processes,they play essential roles in linking genotypes to phenotypes.Abnormalities in protein expression and post-translational modifications(PTMs)are closely associated with the initiation and development of cancer,and they carry biological information inaccessible to genomics and transcriptomics1.Proteomics complements genomic and transcriptomic data,thus enabling comprehensive analysis of cancer pathogenesis and accelerating biomedical research2.展开更多
Esophageal cancer is one of the leading causes of cancer death in the world,with approximately half of the new cases occurring in China every year.^(1)Esophageal squamous cell carcinoma(ESCC)is the main subtype,accoun...Esophageal cancer is one of the leading causes of cancer death in the world,with approximately half of the new cases occurring in China every year.^(1)Esophageal squamous cell carcinoma(ESCC)is the main subtype,accounting for more than 90%,and the five-year survival rate is less than 10%.Using large-scale genome analysis,many driver mutations and key pathways associated with ESCC have been identified.However,these genomic signatures have not improved the clinical management of EscC patients,or established effective targeted therapy.^(2)Esophageal cancer still lacks representative molecular markers.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.81872372)the Natural Science Foundation of Heilongjiang Province(Grant No.LH2021F048)the National Fund cultivation special project(Grant No.2021GJ09)。
文摘Proteins are key players in various cellular processes.As the ultimate executors of cellular processes,they play essential roles in linking genotypes to phenotypes.Abnormalities in protein expression and post-translational modifications(PTMs)are closely associated with the initiation and development of cancer,and they carry biological information inaccessible to genomics and transcriptomics1.Proteomics complements genomic and transcriptomic data,thus enabling comprehensive analysis of cancer pathogenesis and accelerating biomedical research2.
基金supported by grants from National Natural ScienceFoundationof China(No.82002975 and No.82173011)Special Fund for Science and Technology of Guangdong Province(No.200105215896551).
文摘Esophageal cancer is one of the leading causes of cancer death in the world,with approximately half of the new cases occurring in China every year.^(1)Esophageal squamous cell carcinoma(ESCC)is the main subtype,accounting for more than 90%,and the five-year survival rate is less than 10%.Using large-scale genome analysis,many driver mutations and key pathways associated with ESCC have been identified.However,these genomic signatures have not improved the clinical management of EscC patients,or established effective targeted therapy.^(2)Esophageal cancer still lacks representative molecular markers.
