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Long-term outcome of ketoconazole and tacrolimus coadministration in kidney transplant patients 被引量:1
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作者 enver khan Mary Killackey +7 位作者 Damodar Kumbala Heather LaGuardia Yong-Jun Liu Huai-Zhen Qin Brent Alper Anil Paramesh Joseph Buell Rubin Zhang 《World Journal of Nephrology》 2014年第3期107-113,共7页
AIM: To study the long-term outcome of ketoconazole and tacrolimus combination in kidney transplant recipi-ents. METHODS: From 2006 to 2010, ketoconazole was given in 199 patients and was continued for at least 1 y... AIM: To study the long-term outcome of ketoconazole and tacrolimus combination in kidney transplant recipi-ents. METHODS: From 2006 to 2010, ketoconazole was given in 199 patients and was continued for at least 1 year or until graft failure (Group 1), while 149 patients did not receive any ketoconazole (Group 2). A combina-tion of tacrolimus, mycophenolate and steroid was used as maintenance therapy. High risk patients received basiliximab induction. RESULTS: Basic demographic data was similar be-tween the 2 groups. The 5-year cumulative incidence of biopsy-confrmed and clinically-treated acute rejection was signifcantly higher in Group 1 than in Group 2 (34% vs 18%, P = 0.01). The 5-year Kaplan-Meier estimated graft survival (74.3% vs 76.4%, P = 0.58) and patient survival (87.8% vs 87.5%, P = 0.93) were not different between the 2 groups. Multivariable analyses identifed ketoconazole usage as an independent risk of acute rejection (HR = 2.33, 95%CI: 1.33-4.07; P = 0.003) while tacrolimus dose in the 2nd month was protective (HR = 0.89, 95%CI: 0.75-0.96; P = 0.041). CONCLUSION: Co-administration of ketoconazole and tacrolimus is associated with significantly higher inci-dence of acute rejection in kidney transplant recipients. 展开更多
关键词 Kidney transplant REJECTION Survival Tacrolimus Ketoconazole Pharmacokinetics Cytochrome P450
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