Hepatic stellate cell （HSC） activation is an essential event during liver fibrogene- sis. Phosphatase and tension homolog deleted on chromosome 10 （PTEN）, a tumor suppressor, is a negative regulator of this proces...Hepatic stellate cell （HSC） activation is an essential event during liver fibrogene- sis. Phosphatase and tension homolog deleted on chromosome 10 （PTEN）, a tumor suppressor, is a negative regulator of this process. PTEN promoter hypermethylation is a major epigenetic si- lencing mechanism in tumors. The present study aimed to investigate whether PTEN promoter methylation was involved in HSCs activation and liver fibrosis, we observed that hypermethyla- tion of PTEN gene was responsible for the decrease of PTEN expression during HSCs展开更多
文摘Hepatic stellate cell （HSC） activation is an essential event during liver fibrogene- sis. Phosphatase and tension homolog deleted on chromosome 10 （PTEN）, a tumor suppressor, is a negative regulator of this process. PTEN promoter hypermethylation is a major epigenetic si- lencing mechanism in tumors. The present study aimed to investigate whether PTEN promoter methylation was involved in HSCs activation and liver fibrosis, we observed that hypermethyla- tion of PTEN gene was responsible for the decrease of PTEN expression during HSCs
