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Assessing vulnerability to panic:a systematic review of psychological and physiological responses to biological challenges as prospective predictors of panic attacks and panic disorder 被引量:1
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作者 Donald J Robinaugh Meredith J Ward +4 位作者 Emma R Toner Mackenzie L Brown Olivia M Losiewicz eric bui Scott P Orr 《General Psychiatry》 CSCD 2019年第6期297-303,共7页
Background Cognitive-behavioural theories of panic disorder posit that panic attacks arise from a positive feedback loop between arousal-related bodily sensations and perceived threat.In a recently develope computatio... Background Cognitive-behavioural theories of panic disorder posit that panic attacks arise from a positive feedback loop between arousal-related bodily sensations and perceived threat.In a recently develope computational model formalising these theories of pani attacks,it was observed that the response to a simulate perturbation to arousal provided a strong indicator of vulnerability to panic attacks and panic disorder.In this/review,we evaluate whether this observation is borne o in the empirical literature that has examined responses biological challenge(eg,C02 inhalation)and their relatio to subsequent panic attacks and panic disorder.Method We searched PubMed,Web of Science and PsycINFO using keywords denoting provocation agents(eg,sodium lactate)and procedures(eg,infusion)combined with keywords relevant to panic disorder(eg,panic).Articles were eligible if they used response to a biologic challenge paradigm to prospectively predict panic attac or panic disorder.Results We identified four eligible studies.Pooled effect sizes suggest that there is biological challenge response a moderate prospective association with subsequent pani attacks,but no prospective relationship with panic disorde Conclusions These findings provide support for the prediction derived from cognitive-behavioural theories an some preliminary evidence that response to a biological challenge may have clinical utility as a marker of vulnerab to panic attacks pending further research and developme Trial registration number 135908. 展开更多
关键词 behaviour subsequent SIZES
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Pharmacotherapy of anxiety disorders in the 21st century:a call for novel approaches 被引量:1
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作者 eric bui Franklin King Andrew Melaragno 《General Psychiatry》 CSCD 2019年第6期304-308,共5页
While limited advances have occurred in the past 30 years in the pharmacological management of anxiety and stressrelated disorders,novel molecular pathways both within and without the monoamine systems are currently u... While limited advances have occurred in the past 30 years in the pharmacological management of anxiety and stressrelated disorders,novel molecular pathways both within and without the monoamine systems are currently under investigation and offer promising new avenues for more effective future treatments.Enhancing psychotherapy approaches with pharmacological compounds offers the potential to not only transform the standard of care of these conditions,but more broadly would introduce a paradigm shift in the way medications and their role in psychiatric care are conceptualised.Although further human trials and more translational research are sorely needed,continuing to pursue innovative mechanisms and treatments is hoped to yield substantial results in the coming decades and a departure from the reliance on chemical agents of the 20th century. 展开更多
关键词 DEPARTURE ANXIETY INNOVATIVE
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Influence of intranasal oxytocin on fear consolidation in healthy humans
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作者 Elizabeth Hoge eric bui +4 位作者 Peter Rosencrans Scott Orr Rachel Ross Rebecca Ojserkis Naomi Simon 《General Psychiatry》 CSCD 2019年第6期327-334,共8页
Background Although recent data in healthy humans suggestthat treatment with intranasal oxytocin(0T)may facilitate extinction recall,to date,little is known about the effects of 0T on memory consolidationprocesses.Aim... Background Although recent data in healthy humans suggestthat treatment with intranasal oxytocin(0T)may facilitate extinction recall,to date,little is known about the effects of 0T on memory consolidationprocesses.Aim To examine the effect of intranasal administration of OT compared with placebo on memory consolidation blockade of a de novo fear memory in a classical 2-day fear conditioning procedure.Results There were no significant differences between the 0T and the placebo groups on the first two extinction trials(mean(SD)=0.01(0.39)vs 0.15(0.31),t=-1.092,p=0.28).Similarly,during early extinction,analysis of variance for repeated measures failed to show significant main effects of extinction trials:trials(F(4,112)=1.58,p=0.18),drug(F(1,112)=0.13,p=0.72)or drug x trials interaction(F(4,112)=0.76,p=0.56).Conclusion Our results suggest that 0T administered in a double-blind fashion immediately after fear conditioning does not significantly reduce consolidation of fear learning as measured by a differential skin conductance response tested at the beginning of extinction. 展开更多
关键词 EXTINCTION CONSOLIDATION measures
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Acceptability of an adjunct equine-assisted activities and therapies program for veterans with posttraumatic stress disorder and/or traumatic brain injury 被引量:2
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作者 Louisa Sylvia Emerson West +7 位作者 Allyson M.Blackburn Carina Gupta eric bui Tara Mahoney Geraldine Duncan Edward C.Wright Simon Lejeune Thomas J.Spencer 《Journal of Integrative Medicine》 SCIE CAS CSCD 2020年第2期169-173,共5页
Objective: Equine-assisted activities and therapies(EAATs) have been a growing adjunctive integrative health modality, as they allow participants to practice mindfulness, emotional regulation, and self-mastery or self... Objective: Equine-assisted activities and therapies(EAATs) have been a growing adjunctive integrative health modality, as they allow participants to practice mindfulness, emotional regulation, and self-mastery or self-esteem building skills. Preliminary evidence suggests that these programs may be helpful in reducing posttraumatic stress disorder(PTSD), anxiety, and depressive symptoms. The current study examines the acceptability of integrating an EAAT program as part of a two-week, intensive clinical program for veterans with PTSD and/or traumatic brain injury(TBI).Methods: A family member or support person could accompany veterans and participate in the program.One hundred and six participants(veteran n = 62, family n = 44) left the urban environment in an intensive outpatient program(IOP) to attend a two-day, weekend EAAT in rural New Hampshire. Satisfaction surveys were conducted on the last day of the program and examined using thematic analysis.Results: The following themes were reported in the surveys: ability of horses to catalyze emotional rehabilitation, effectiveness of immersion in equine-assisted activities, program’s ability to foster interpersonal relationships and necessity of education about PTSD for staff. Participants also reported enjoying the program as highlighted by qualitative feedback, a mean score of 9.76(standard deviation[SD] = 0.61) as reported by veterans and a mean score of 9.91(SD = 0.29) as reported by family members on a 10-point visual analog scale with higher scores indicating a greater overall experience.Conclusion: These data offer preliminary evidence that an adjunct EAAT program is acceptable for veterans with PTSD and/or TBI participating in an IOP. 展开更多
关键词 POSTTRAUMATIC stress disorder Military personnel Traumatic brain injury Complementary and alternative medicine Equine-assisted therapy
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