Natural cytotoxicity receptors(NCRs)are expressed on natural killer(NK)cells and other subsets of innate lymphoid cells(ILC).Three NCRs,NKp30,NKp44 and NKp46,are expressed on human NK cells.1 NKp46 is the only NCR sha...Natural cytotoxicity receptors(NCRs)are expressed on natural killer(NK)cells and other subsets of innate lymphoid cells(ILC).Three NCRs,NKp30,NKp44 and NKp46,are expressed on human NK cells.1 NKp46 is the only NCR shared by primates and rodents,suggesting an essential role for this receptor during evolution.2 While cellular ligands for NKp30 and NKp44 have been identified,a well-characterized non-microbial ligand for NKp46 is still lacking.However,in a recent paper in Science Immunology,Narni-Mancinelli et al.3 reported the identification of complement factor P(CFP,also known as properdin)as a ligand of NKp46.展开更多
基金by a grant from the Intramural Research Program of the National Institutes of Health,National Institute of Allergy and Infectious Diseases.
文摘Natural cytotoxicity receptors(NCRs)are expressed on natural killer(NK)cells and other subsets of innate lymphoid cells(ILC).Three NCRs,NKp30,NKp44 and NKp46,are expressed on human NK cells.1 NKp46 is the only NCR shared by primates and rodents,suggesting an essential role for this receptor during evolution.2 While cellular ligands for NKp30 and NKp44 have been identified,a well-characterized non-microbial ligand for NKp46 is still lacking.However,in a recent paper in Science Immunology,Narni-Mancinelli et al.3 reported the identification of complement factor P(CFP,also known as properdin)as a ligand of NKp46.
