Human immunodeficiency virus-1 capsid(HIV-1 CA) is involved in different stages of the viral replication cycle. During virion assembly, CA drives the formation of the hexameric lattice in immature viral particles, whi...Human immunodeficiency virus-1 capsid(HIV-1 CA) is involved in different stages of the viral replication cycle. During virion assembly, CA drives the formation of the hexameric lattice in immature viral particles, while in mature virions CA monomers assemble in cone-shaped cores surrounding the viral RNA genome and associated proteins. In addition to its functions in late stages of the viral replication cycle, CA plays key roles in a number of processes during early phases of HIV-1 infection including trafficking, uncoating, recognition by host cellular proteins and nuclear import of the viral preintegration complex. As a result of efficient cooperation of CA with other viral and cellular proteins, integration of the viral genetic material into the host genome, which is an essential step for productive viral infection, successfully occurs. In this review, we will summarize available data on CA functions in HIV-1 replication, describing in detail its roles in late and early phases of the viral replication cycle.展开更多
Viral infections remain a global threat to world health in the twenty-first century. They are caused by both DNA and RNA viruses and can manifest as acute or chronic infections, in some cases causing epidemics or even...Viral infections remain a global threat to world health in the twenty-first century. They are caused by both DNA and RNA viruses and can manifest as acute or chronic infections, in some cases causing epidemics or even global pandemics.Persistent viral infections lead to host immunodeficiency and the development of ~12% of human cancers worldwide.展开更多
基金supported by the Intramural Research Program of the Center for Cancer Research, National Cancer Institute, NIHthe Intramural AIDS Targeted Antiviral Program+4 种基金supported by National Natural Science Foundation of China (No. 31770188)Strategic Priority Research Program of the Chinese Academy of Sciences (XDB29010000)the National Science and Technology Major Project (No. 2018ZX10101004)the Special major program of Wuhan Institute of Virology (No. WIV-135-TP1)the Hundred Talents Program of Chinese Academy of Sciences, and the State Key Laboratory of Virology open projects (No. 2017IOV003)
文摘Human immunodeficiency virus-1 capsid(HIV-1 CA) is involved in different stages of the viral replication cycle. During virion assembly, CA drives the formation of the hexameric lattice in immature viral particles, while in mature virions CA monomers assemble in cone-shaped cores surrounding the viral RNA genome and associated proteins. In addition to its functions in late stages of the viral replication cycle, CA plays key roles in a number of processes during early phases of HIV-1 infection including trafficking, uncoating, recognition by host cellular proteins and nuclear import of the viral preintegration complex. As a result of efficient cooperation of CA with other viral and cellular proteins, integration of the viral genetic material into the host genome, which is an essential step for productive viral infection, successfully occurs. In this review, we will summarize available data on CA functions in HIV-1 replication, describing in detail its roles in late and early phases of the viral replication cycle.
文摘Viral infections remain a global threat to world health in the twenty-first century. They are caused by both DNA and RNA viruses and can manifest as acute or chronic infections, in some cases causing epidemics or even global pandemics.Persistent viral infections lead to host immunodeficiency and the development of ~12% of human cancers worldwide.
