The coordinated interplay between neurons and astroglia,the latter producing essential metabolic precursors for neurons,is critical for the precision of neurotransmission in the execution of specific behaviors.Most re...The coordinated interplay between neurons and astroglia,the latter producing essential metabolic precursors for neurons,is critical for the precision of neurotransmission in the execution of specific behaviors.Most recently,Jimenez-Blasco et al.1 identified CB1 cannabinoid receptors in astroglial mitochondria as gatekeepers of lactate production by regulating the stability of mitochondrial complex I through the hypoxia-inducible factor-1 pathway and thus,metabolically tuning neurons that control social behaviors.展开更多
基金supported by the National Brain Research Program of Hungary(2017-1.2.1-NKP-2017-00002 to A.A.)Excellence Program for Higher Education of Hungary(FIKP-2018,A.A.)+6 种基金the Swedish Medical Research Council(Vetenskapsrådet,2018-02838T.H.),Hjärnfonden(F2020-0178T.H.)The Novo Nordisk Foundation(NNF17OC0027294T.H.)the European Research Council(ERC-2015-AdG-695136T.H.).
文摘The coordinated interplay between neurons and astroglia,the latter producing essential metabolic precursors for neurons,is critical for the precision of neurotransmission in the execution of specific behaviors.Most recently,Jimenez-Blasco et al.1 identified CB1 cannabinoid receptors in astroglial mitochondria as gatekeepers of lactate production by regulating the stability of mitochondrial complex I through the hypoxia-inducible factor-1 pathway and thus,metabolically tuning neurons that control social behaviors.
