Background: Lichen planus (LP) is classified as a papulosquamous disease. It has been associated with liver disease, particularly hepatitis C virus (HCV) infection, in several studies. Most of these reports, especiall...Background: Lichen planus (LP) is classified as a papulosquamous disease. It has been associated with liver disease, particularly hepatitis C virus (HCV) infection, in several studies. Most of these reports, especially the larger series, were conducted in Europe and Japan. Objective: We conducted a case-control stud y in Kerman, Iran to explore the association between LP andHCV.Methods: The stud y included 66 patients with LP (as cases; mean age=39.7 ±15.8 years; 31 female, 35 male) and 140 volunteer blood donors (as controls; mean age=29.5 ±8.4 years ; 43 females, 97 males). An enzymelinked immunosorbent assay (ELISA) was used to determine the presence of anti-HCV antibodies in all subjects in both groups. To confirm positive diagnoses, a second generation recombinant immunoblot assay (RIBA II) test was performed. Results: Lichen planus lesions were most frequentl y located on the trunk and extremities, and the most common clinical type was ge neralized LP (48.5%). One of the patients with LP (1.5%) and three of the cont rols (2.1%) were HCV-Ab positive. No significant difference was observed in HC V-Ab positive between the two groups (OR=0.7; 95%CI=0.1-6.9). Conclusion: The findings indicate that an investigation for HCV infection should not necessaril y be performed in all patients with LP. It is recommended that further studies s hould focus on larger groups in other regions of Iran to determine whether testi ng for HCV infection is necessary in patients with LP.展开更多
文摘Background: Lichen planus (LP) is classified as a papulosquamous disease. It has been associated with liver disease, particularly hepatitis C virus (HCV) infection, in several studies. Most of these reports, especially the larger series, were conducted in Europe and Japan. Objective: We conducted a case-control stud y in Kerman, Iran to explore the association between LP andHCV.Methods: The stud y included 66 patients with LP (as cases; mean age=39.7 ±15.8 years; 31 female, 35 male) and 140 volunteer blood donors (as controls; mean age=29.5 ±8.4 years ; 43 females, 97 males). An enzymelinked immunosorbent assay (ELISA) was used to determine the presence of anti-HCV antibodies in all subjects in both groups. To confirm positive diagnoses, a second generation recombinant immunoblot assay (RIBA II) test was performed. Results: Lichen planus lesions were most frequentl y located on the trunk and extremities, and the most common clinical type was ge neralized LP (48.5%). One of the patients with LP (1.5%) and three of the cont rols (2.1%) were HCV-Ab positive. No significant difference was observed in HC V-Ab positive between the two groups (OR=0.7; 95%CI=0.1-6.9). Conclusion: The findings indicate that an investigation for HCV infection should not necessaril y be performed in all patients with LP. It is recommended that further studies s hould focus on larger groups in other regions of Iran to determine whether testi ng for HCV infection is necessary in patients with LP.
