Background. Behc.et’s disease (BD) is a multisystemic disease of unknown etio logy characterized by chronic relapsing oral-genital ulcers and uveitis. Some a bnormalities in lipoprotein metabolism have been described...Background. Behc.et’s disease (BD) is a multisystemic disease of unknown etio logy characterized by chronic relapsing oral-genital ulcers and uveitis. Some a bnormalities in lipoprotein metabolism have been described in patients with BD. Methods. In this study, apolipoprotein E (apo E) polymorphism and lipoprotein ch olesterol concentrations in 30 patients with BD were compared with those of 27 c ontrol subjects. Results. Both patients and controls were found to be normolipid emic. Patients with BD had significantly higher concentrations of high-density lipoprotein (HDL) cholesterol than those of controls (P < .0.05); however, there was no difference in serum triglyceride, low-densitylipoprotein(LDL)and very l ow-density lipoprotein (VLDL) cholesterol concentrations. The distribution of a po E genotypes and alleles was the same in both groups. There were slight differ ences in allele frequency between the groups, but this was not statistically sig nificant. Conclusions. The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles.展开更多
It is possible that dietary, environmental factors and/or genetic polymorphism s in xenobiotic-metabolizing enzymes may contribute to the development of Behce t’s disease. As N-acetyltransferase (NAT) 2 is an importa...It is possible that dietary, environmental factors and/or genetic polymorphism s in xenobiotic-metabolizing enzymes may contribute to the development of Behce t’s disease. As N-acetyltransferase (NAT) 2 is an important xenobiotic-metabo lizing enzyme and theoretically the nonacetylated xenobiotics may induce an auto immune mechanism, the aim of the present study was to investigate whether the ge netic polymorphism of NAT2 plays a role in susceptibility to Behcet’s disease. Forty Behcet’s disease patients and 82 control subjects were enrolled in the st udy. NAT2.5A, NAT2.6A, NAT27.A/B and NAT2.14A polymorphisms were detected by usi ng real time PCR with LightCycler (Roche Diagnostics GmbH, Mannheim, Germany). T he NAT2.5A and NAT2.6A mutant genotypes carried an increased risk of developing Behcet’s disease [odds ratio(OR) =66.29,95%confidenceinterval(CI) =8.21-535. 3 3; and OR = 24; 95%CI = 2.04-304.98, respectively]. The NAT2.7A/B and NAT2.14 A gene polymorphisms were not an increased risk for developing Behcet’s disease. As a result of this study we conclude the NAT2 slow acetylator status may be a determinant in susceptibility to Behcet’s disease. This finding may have implic ations for the theories of the pathogenesis of the disease as well as for therap eutic aspects.展开更多
文摘Background. Behc.et’s disease (BD) is a multisystemic disease of unknown etio logy characterized by chronic relapsing oral-genital ulcers and uveitis. Some a bnormalities in lipoprotein metabolism have been described in patients with BD. Methods. In this study, apolipoprotein E (apo E) polymorphism and lipoprotein ch olesterol concentrations in 30 patients with BD were compared with those of 27 c ontrol subjects. Results. Both patients and controls were found to be normolipid emic. Patients with BD had significantly higher concentrations of high-density lipoprotein (HDL) cholesterol than those of controls (P < .0.05); however, there was no difference in serum triglyceride, low-densitylipoprotein(LDL)and very l ow-density lipoprotein (VLDL) cholesterol concentrations. The distribution of a po E genotypes and alleles was the same in both groups. There were slight differ ences in allele frequency between the groups, but this was not statistically sig nificant. Conclusions. The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles.
文摘It is possible that dietary, environmental factors and/or genetic polymorphism s in xenobiotic-metabolizing enzymes may contribute to the development of Behce t’s disease. As N-acetyltransferase (NAT) 2 is an important xenobiotic-metabo lizing enzyme and theoretically the nonacetylated xenobiotics may induce an auto immune mechanism, the aim of the present study was to investigate whether the ge netic polymorphism of NAT2 plays a role in susceptibility to Behcet’s disease. Forty Behcet’s disease patients and 82 control subjects were enrolled in the st udy. NAT2.5A, NAT2.6A, NAT27.A/B and NAT2.14A polymorphisms were detected by usi ng real time PCR with LightCycler (Roche Diagnostics GmbH, Mannheim, Germany). T he NAT2.5A and NAT2.6A mutant genotypes carried an increased risk of developing Behcet’s disease [odds ratio(OR) =66.29,95%confidenceinterval(CI) =8.21-535. 3 3; and OR = 24; 95%CI = 2.04-304.98, respectively]. The NAT2.7A/B and NAT2.14 A gene polymorphisms were not an increased risk for developing Behcet’s disease. As a result of this study we conclude the NAT2 slow acetylator status may be a determinant in susceptibility to Behcet’s disease. This finding may have implic ations for the theories of the pathogenesis of the disease as well as for therap eutic aspects.
