A recent study attempts to add to the body of evidence that is emerging regarding the fish oil parenteral lipid product OmegavenTM.The authors have shown from explant livers of children on chronic parenteral nutrition...A recent study attempts to add to the body of evidence that is emerging regarding the fish oil parenteral lipid product OmegavenTM.The authors have shown from explant livers of children on chronic parenteral nutrition with OmegavenTM that biochemical improvement in cholestasis does not always reflect improvement in liver histology.These findings support 2 small case series that were previously published.Despite improvement and resolution of hyperbilirubinemia in all six infants,five of six infants had persistent or progressive hepatic fibrosis,while only one infant had regression of fibrosis.The study raises questions of whether there is a window of opportunity for efficacy of this preparation;also,an important question is if this omega-3 fatty acid-rich preparation is superior to newer "blended lipids" containing olive,coconut,soy,and fish oil.展开更多
文摘A recent study attempts to add to the body of evidence that is emerging regarding the fish oil parenteral lipid product OmegavenTM.The authors have shown from explant livers of children on chronic parenteral nutrition with OmegavenTM that biochemical improvement in cholestasis does not always reflect improvement in liver histology.These findings support 2 small case series that were previously published.Despite improvement and resolution of hyperbilirubinemia in all six infants,five of six infants had persistent or progressive hepatic fibrosis,while only one infant had regression of fibrosis.The study raises questions of whether there is a window of opportunity for efficacy of this preparation;also,an important question is if this omega-3 fatty acid-rich preparation is superior to newer "blended lipids" containing olive,coconut,soy,and fish oil.
