Objective: To determine the incidence, natural history, and clinical characte ristics of Hashitoxicosis (Htx) in pediatric patients with autoimmnune thyroidit is. Study design: Medical records of children diagnosed wi...Objective: To determine the incidence, natural history, and clinical characte ristics of Hashitoxicosis (Htx) in pediatric patients with autoimmnune thyroidit is. Study design: Medical records of children diagnosed with Hashimoto thyroidit is between 1993 and 2002 were reviewed. The clinical course of patients presenti ng with hyperthyroidism was determined. Variables including sex, age, family his tory, thyroid hormone levels, anti- thyroid antibody titers, 123I thyroid scan results, and presenting features were investigated as possible predisposing fact ors for the development of Htx. Results: Out of 69 patients with autoimmune thyr oiditis, 8 were diagnosed with Htx. The duration of hyperthyroidism ranged from 31 to 168 days. Three patients became hypothyroid after an average of 46.3 ± 1 3.2 days, and 5 patients became euthyroid after an average of 112.8 ± 59.8 day s. Additional findings included an elevated thyroid stimulating immunoglobulin ( TSI) titer in 3 of the 8 patients with Htx, and increased uptake on 123I scan in 2 patients. Conclusion: Htx is an uncommon yet important cause of hyperthyroidi sm in children that has a variable clinical course. The diagnosis may be complic ated, as presenting features sometimes exhibit significant overlap with Graves disease. No factors predisposing to the development of Htx were identified.展开更多
文摘Objective: To determine the incidence, natural history, and clinical characte ristics of Hashitoxicosis (Htx) in pediatric patients with autoimmnune thyroidit is. Study design: Medical records of children diagnosed with Hashimoto thyroidit is between 1993 and 2002 were reviewed. The clinical course of patients presenti ng with hyperthyroidism was determined. Variables including sex, age, family his tory, thyroid hormone levels, anti- thyroid antibody titers, 123I thyroid scan results, and presenting features were investigated as possible predisposing fact ors for the development of Htx. Results: Out of 69 patients with autoimmune thyr oiditis, 8 were diagnosed with Htx. The duration of hyperthyroidism ranged from 31 to 168 days. Three patients became hypothyroid after an average of 46.3 ± 1 3.2 days, and 5 patients became euthyroid after an average of 112.8 ± 59.8 day s. Additional findings included an elevated thyroid stimulating immunoglobulin ( TSI) titer in 3 of the 8 patients with Htx, and increased uptake on 123I scan in 2 patients. Conclusion: Htx is an uncommon yet important cause of hyperthyroidi sm in children that has a variable clinical course. The diagnosis may be complic ated, as presenting features sometimes exhibit significant overlap with Graves disease. No factors predisposing to the development of Htx were identified.
