Clear Cell Sarcoma (CCS) is a rare soft tissue sarcoma that corresponds <span style="font-family:Verdana;">to </span><span style="font-family:Verdana;">a less than 1% of all sarco...Clear Cell Sarcoma (CCS) is a rare soft tissue sarcoma that corresponds <span style="font-family:Verdana;">to </span><span style="font-family:Verdana;">a less than 1% of all sarcomas</span><span style="font-family:Verdana;"> and</span><span style="font-family:Verdana;"> is a high degree neoplasm with propensity to disseminate to regional lymph nodes. Regional lymphadenectomies have </span><span style="font-family:Verdana;">a </span><span style="font-family:Verdana;">controversial impact on sarcomas treatment and survival, even though those patients have higher local recurrence and lower survival. So, sentinel lymph node biopsy must be one option for better regional staging to STS with higher propensity to lymph node commitment. The authors demonstrate two cases of CCS submitted to surgery through compartmental resection associated </span><span style="font-family:Verdana;">with</span><span style="font-family:Verdana;"> the sentinel lymph node biopsy. A literature review about soft tissue sarcoma and lymph node sentinel biopsy </span><span style="font-family:Verdana;">is</span><span style="font-family:Verdana;"> show</span><span style="font-family:Verdana;">n </span><span style="font-family:Verdana;">as an initial experience of two cases.</span>展开更多
Soft tissue sarcomas (STS) are rare neoplasm with frequencies around 1% of all neoplasms. Although it consists of a high heterogeneous group of tumors, surgery is the mean treatment. The STS surgery is still challengi...Soft tissue sarcomas (STS) are rare neoplasm with frequencies around 1% of all neoplasms. Although it consists of a high heterogeneous group of tumors, surgery is the mean treatment. The STS surgery is still challenging and complex procedure is usually required: this is because STS requires different types of resection and reconstruction due to various tissue-commitment</span><span style="font-family:"">s</span><span style="font-family:""> (nerve, arteries, skin and muscle). So, a multidisciplinary team must be prepared for STS approach to obtain the maximum local control and a limited extremity functional impairment. We, here, showing our experience, wish to introduce some technical contrivances in STS surgery, with special reference to tissue reconstruction. This may illustrate the necessity of a multidisciplinary team approach in this surgery.展开更多
<strong>Objectives:</strong><span style="font-family:""><span style="font-family:Verdana;"> We aimed to determine the frequency of PTEN (phosphatase with tensin homolog...<strong>Objectives:</strong><span style="font-family:""><span style="font-family:Verdana;"> We aimed to determine the frequency of PTEN (phosphatase with tensin homology deleted in chromosome 10) hypermethylation in renal cell carcinoma (RCC) and its impact on overall (OS) and disease-free survival (DFS). The association between PTEN hypermethylation and clinic and pathologic factors was also analyzed. </span><b><span style="font-family:Verdana;">Materials and Methods: </span></b><span style="font-family:Verdana;">The authors analyzed 137 patients who had undergone a radical or partial nephrectomy between 1997 and 2011. The methylation pattern was quantified individually at multiple CpG islands that are located on the exon 1 of PTEN gene by pyrosequencing.</span></span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Mean follow-up was 32</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;">3 months. PTEN hypermethylation was detected with a low frequency (3.6%). There were no deaths or disease recurrence among patients with PTEN hypermethylation. Determining the association between PTEN hypermethylation and clinical and pathological factors was not possible due to the low frequency observed.</span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The results show that the methylation of promoter CpG sites in PTEN is relatively infrequent in renal carcinogenesis and has no prognostic impact on survival.</span>展开更多
文摘Clear Cell Sarcoma (CCS) is a rare soft tissue sarcoma that corresponds <span style="font-family:Verdana;">to </span><span style="font-family:Verdana;">a less than 1% of all sarcomas</span><span style="font-family:Verdana;"> and</span><span style="font-family:Verdana;"> is a high degree neoplasm with propensity to disseminate to regional lymph nodes. Regional lymphadenectomies have </span><span style="font-family:Verdana;">a </span><span style="font-family:Verdana;">controversial impact on sarcomas treatment and survival, even though those patients have higher local recurrence and lower survival. So, sentinel lymph node biopsy must be one option for better regional staging to STS with higher propensity to lymph node commitment. The authors demonstrate two cases of CCS submitted to surgery through compartmental resection associated </span><span style="font-family:Verdana;">with</span><span style="font-family:Verdana;"> the sentinel lymph node biopsy. A literature review about soft tissue sarcoma and lymph node sentinel biopsy </span><span style="font-family:Verdana;">is</span><span style="font-family:Verdana;"> show</span><span style="font-family:Verdana;">n </span><span style="font-family:Verdana;">as an initial experience of two cases.</span>
文摘Soft tissue sarcomas (STS) are rare neoplasm with frequencies around 1% of all neoplasms. Although it consists of a high heterogeneous group of tumors, surgery is the mean treatment. The STS surgery is still challenging and complex procedure is usually required: this is because STS requires different types of resection and reconstruction due to various tissue-commitment</span><span style="font-family:"">s</span><span style="font-family:""> (nerve, arteries, skin and muscle). So, a multidisciplinary team must be prepared for STS approach to obtain the maximum local control and a limited extremity functional impairment. We, here, showing our experience, wish to introduce some technical contrivances in STS surgery, with special reference to tissue reconstruction. This may illustrate the necessity of a multidisciplinary team approach in this surgery.
文摘<strong>Objectives:</strong><span style="font-family:""><span style="font-family:Verdana;"> We aimed to determine the frequency of PTEN (phosphatase with tensin homology deleted in chromosome 10) hypermethylation in renal cell carcinoma (RCC) and its impact on overall (OS) and disease-free survival (DFS). The association between PTEN hypermethylation and clinic and pathologic factors was also analyzed. </span><b><span style="font-family:Verdana;">Materials and Methods: </span></b><span style="font-family:Verdana;">The authors analyzed 137 patients who had undergone a radical or partial nephrectomy between 1997 and 2011. The methylation pattern was quantified individually at multiple CpG islands that are located on the exon 1 of PTEN gene by pyrosequencing.</span></span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Mean follow-up was 32</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;">3 months. PTEN hypermethylation was detected with a low frequency (3.6%). There were no deaths or disease recurrence among patients with PTEN hypermethylation. Determining the association between PTEN hypermethylation and clinical and pathological factors was not possible due to the low frequency observed.</span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The results show that the methylation of promoter CpG sites in PTEN is relatively infrequent in renal carcinogenesis and has no prognostic impact on survival.</span>