The Schiff base, 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L<sub>1</sub>) has been synthesized by the condensation reaction between 2-aminopyrimidine and 2-benzoylpyridine and char...The Schiff base, 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L<sub>1</sub>) has been synthesized by the condensation reaction between 2-aminopyrimidine and 2-benzoylpyridine and characterized using <sup>13</sup>C-NMR, <sup>1</sup>H-NMR, microanalysis, FT-IR, DEPT-135, HSQC, HMBC, COZY, NOESY. The reaction of 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L<sub>1</sub>) with salts of V(IV), Co(II) and Cu(II), however, resulted in the hydrolysis of L<sub>1</sub> to give binuclear metal complexes of 2-benzoylpyridine (L<sub>2</sub>) and phenyl(pyridin-2-yl)methanediol (L<sub>3</sub>) which were characterized using UV-visible spectroscopy, and TGA. The single crystal x-ray structure determined for the Copper(II) complex revealed that we obtained a compound previously obtained using a different method of synthesis. The Schiff base ligand (L<sub>1</sub>) is soluble in methanol, ethanol, DMSO, acetone and DMF. Microanalysis and Spectroscopic studies indicated that binuclear metal complexes were obtained by the coordination of metal ion to 2-benzoylpyridine (L<sub>2</sub>) and phenyl(pyridin-2-yl)methanediol (L<sub>3</sub>) from the hydrolysis of L<sub>1</sub>. Spectroscopic and elemental analysis reveal the formation of square pyramidal complexes of Co(II) and Cu(II) and a square planar complex of V(IV). <i>In vitro</i> antibacterial and antifungal activity against three bacterial strains (<i>Escherichia coli, Klebsiella pneumoniae</i> and <i>Staphylococcus aureus</i>) and three fungal stains (<i>Candida albicans, Candida glabrata and Candida parapsilosis</i>) showed moderate biological activity. Antioxidant studies reveal that only the binuclear Co(II) and oxovanadium(II) complexes are potent to eliminate free radicals.展开更多
文摘The Schiff base, 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L<sub>1</sub>) has been synthesized by the condensation reaction between 2-aminopyrimidine and 2-benzoylpyridine and characterized using <sup>13</sup>C-NMR, <sup>1</sup>H-NMR, microanalysis, FT-IR, DEPT-135, HSQC, HMBC, COZY, NOESY. The reaction of 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L<sub>1</sub>) with salts of V(IV), Co(II) and Cu(II), however, resulted in the hydrolysis of L<sub>1</sub> to give binuclear metal complexes of 2-benzoylpyridine (L<sub>2</sub>) and phenyl(pyridin-2-yl)methanediol (L<sub>3</sub>) which were characterized using UV-visible spectroscopy, and TGA. The single crystal x-ray structure determined for the Copper(II) complex revealed that we obtained a compound previously obtained using a different method of synthesis. The Schiff base ligand (L<sub>1</sub>) is soluble in methanol, ethanol, DMSO, acetone and DMF. Microanalysis and Spectroscopic studies indicated that binuclear metal complexes were obtained by the coordination of metal ion to 2-benzoylpyridine (L<sub>2</sub>) and phenyl(pyridin-2-yl)methanediol (L<sub>3</sub>) from the hydrolysis of L<sub>1</sub>. Spectroscopic and elemental analysis reveal the formation of square pyramidal complexes of Co(II) and Cu(II) and a square planar complex of V(IV). <i>In vitro</i> antibacterial and antifungal activity against three bacterial strains (<i>Escherichia coli, Klebsiella pneumoniae</i> and <i>Staphylococcus aureus</i>) and three fungal stains (<i>Candida albicans, Candida glabrata and Candida parapsilosis</i>) showed moderate biological activity. Antioxidant studies reveal that only the binuclear Co(II) and oxovanadium(II) complexes are potent to eliminate free radicals.
