The structural basis of the regulation of serotonin(5-hydroxy-tryptamine,5-HT)receptors by ligands and lipids is only emerging.A recent study by Xu and colleagues1 published in Nature addresses this issue by resolving...The structural basis of the regulation of serotonin(5-hydroxy-tryptamine,5-HT)receptors by ligands and lipids is only emerging.A recent study by Xu and colleagues1 published in Nature addresses this issue by resolving five structures of 5-HT;receptor-G protein complexes.These include 5-HT1A in the apostate,i.e.not bound to a ligand,5-HT1A and 5-HT1D bound to serotonin or the atypical antipsychotic aripiprazole(for 5-HT1A),and 5-HT1E bound to its selective agonist BRL-54443.展开更多
基金A.D.was supported by Bundesministerium fur Bildung und Forschung(BMBF:Energl project,TP 5,01GQ1421A),Deutsche Forschungsgemeinschaft(DFG:SFB 1436,TP AOS-Project-ID 425899996)E.P.was supported by DFG grant P0732+1 种基金MZ.was supported by DFG(FOR 2858,TP B1-Project-ID 422185457)the European Research Council(ERC)under the EU Horizon 2020 research and innovation program(grant agreement no.787679).
文摘The structural basis of the regulation of serotonin(5-hydroxy-tryptamine,5-HT)receptors by ligands and lipids is only emerging.A recent study by Xu and colleagues1 published in Nature addresses this issue by resolving five structures of 5-HT;receptor-G protein complexes.These include 5-HT1A in the apostate,i.e.not bound to a ligand,5-HT1A and 5-HT1D bound to serotonin or the atypical antipsychotic aripiprazole(for 5-HT1A),and 5-HT1E bound to its selective agonist BRL-54443.
