Colorectal cancer (CRC) is significant publichealth problem in rich countries of the world, because of its frequency and mostly because of its severity. Our aim was to improve histologic diagnosis of malignancy with t...Colorectal cancer (CRC) is significant publichealth problem in rich countries of the world, because of its frequency and mostly because of its severity. Our aim was to improve histologic diagnosis of malignancy with topographic coloration (HE) and cytokeratins 7, 20 immuno-labeling. The risk for colorectal cancer incease with age, but in our series, 10% of colorectal cancer exist in patients younger than 40 years old. In histological study, adenocarcinoma represented 100% and the evaluation for stage of disease showed that the most dominant isstage IV (32.6%). In our trial, we found that cytokeratins 7 and 20 immunoreactivity in colorectal adenocarcinoma are often positive for cytokeratin-20 and most of time negative for cytokeratin-7.展开更多
文摘Colorectal cancer (CRC) is significant publichealth problem in rich countries of the world, because of its frequency and mostly because of its severity. Our aim was to improve histologic diagnosis of malignancy with topographic coloration (HE) and cytokeratins 7, 20 immuno-labeling. The risk for colorectal cancer incease with age, but in our series, 10% of colorectal cancer exist in patients younger than 40 years old. In histological study, adenocarcinoma represented 100% and the evaluation for stage of disease showed that the most dominant isstage IV (32.6%). In our trial, we found that cytokeratins 7 and 20 immunoreactivity in colorectal adenocarcinoma are often positive for cytokeratin-20 and most of time negative for cytokeratin-7.
