目的探讨儿童急性坏死性脑病(acute necrotizing encepha-lopathy of childhood,ANEC)的影像及临床特点,为早期识别ANEC提供参考依据。方法选取2010年9月~2020年12月本院ANEC患儿的临床及影像资料,分析本病的临床表现、实验室检查及MRI...目的探讨儿童急性坏死性脑病(acute necrotizing encepha-lopathy of childhood,ANEC)的影像及临床特点,为早期识别ANEC提供参考依据。方法选取2010年9月~2020年12月本院ANEC患儿的临床及影像资料,分析本病的临床表现、实验室检查及MRI特点。结果21例患儿实验室检查血小板计数降低,转氨酶、乳酸脱氢酶、肌酸激酶同工酶不同程度升高,脑脊液细胞计数正常、蛋白定量明显升高,MRI显示病变呈双侧对称性分布,病灶为丘脑21例、基底节区15例、脑干14例、大脑白质14例、小脑8例、胼胝体2例和海马1例,病死率38.1%(8/21)。结论ANEC早期无特异性临床表现,病情进展快,病死率高,在冬季(12月~2月)对于存在高热、意识障碍并伴转氨酶、肌酸激酶同工酶升高的婴幼儿,应尽早完善MRI检查,以早期识别、诊断,为后续治疗、护理争取时间,提高存活率。展开更多
目的探讨拉莫三嗪辅助治疗前庭性偏头痛的临床效果及对血清神经递质水平的影响。方法选择本院2018年4月-2019年7月接诊的前庭性偏头痛患者85例,通过随机数表法分为观察组45例和对照组40例,对照组给予盐酸氟桂利嗪胶囊治疗,观察组给予盐...目的探讨拉莫三嗪辅助治疗前庭性偏头痛的临床效果及对血清神经递质水平的影响。方法选择本院2018年4月-2019年7月接诊的前庭性偏头痛患者85例,通过随机数表法分为观察组45例和对照组40例,对照组给予盐酸氟桂利嗪胶囊治疗,观察组给予盐酸氟桂利嗪胶囊联合拉莫三嗪治疗,均连续治疗2个月,并比较2组临床疗效、眩晕情况、血清神经递质水平的变化及不良反应。结果治疗2个月后观察组总有效率明显高于对照组(91.11%vs 72.50%)(P<0.05);观察组眩晕发作次数、每次眩晕严重程度均明显低于对照组,眩晕持续时间明显短于对照组[(2.05±0.47) vs (2.94±0.61)次/月,(2.43±0.63) vs (3.59±0.88)分,(8.76±1.74) vs (10.09±2.11)h](P<0.05);观察组血清降钙素基因相关肽(CGRP)、P物质(SP)、内皮素-1(ET-1)水平明显低于对照组[(56.75±8.01) vs (66.42±9.65) ng/L,(162.30±15.42) vs (184.21±17.27) ng/L,(72.30±11.38) vs (88.27±13.47) pg/mL](P<0.05);2组不良反应总发生率无明显差异[13.33%vs 12.50%](P>0.05)。结论在氟桂利嗪基础上联合拉莫三嗪辅助治疗前庭性偏头痛的疗效显著,可有效改善血清神经递质表达水平,缓解临床症状,安全性好。展开更多
目的系统评价连续性血液净化非计划下机的影响因素,为预防非计划下机提供参考依据。方法检索中国知网、万方数据库、中国生物医学文献数据库、中文科技期刊全文数据库、PubMed、Web of Science数据库中有关连续性血液净化非计划下机影...目的系统评价连续性血液净化非计划下机的影响因素,为预防非计划下机提供参考依据。方法检索中国知网、万方数据库、中国生物医学文献数据库、中文科技期刊全文数据库、PubMed、Web of Science数据库中有关连续性血液净化非计划下机影响因素的文献,中文数据库检索时间为建库至2021年3月,英文数据库2016年3月至2021年3月。由两名研究者独立进行文献筛选、质量评价及资料提取,采用Stata 14.0软件进行Meta分析。结果共纳入文献11篇,累计连续性血液净化治疗3031例次,发生非计划下机1412例次,各影响因素合并OR值及95%CI分别为:治疗模式2.22(1.06-4.62)、血流速度0.91(0.76-1.09)、意识躁动4.54(2.33-8.86)、使用呼吸机2.67(1.63-4.38)、输入血制品及脂肪乳1.07(0.34-3.36)、一次性置管成功0.26(0.05-1.42)、置管部位(股静脉比颈静脉)2.24(0.83-6.02)。结论非计划下机受多因素影响,本研究显示治疗模式、意识躁动、使用呼吸机是非计划下机的危险因素;血流速度、输入血制品及脂肪乳、一次性置管成功、置管部位与非计划下机无相关性。展开更多
The stochastic resource allocation(SRA) problem is an extensive class of combinatorial optimization problems widely existing in complex systems such as communication networks and unmanned systems. In SRA, the ability ...The stochastic resource allocation(SRA) problem is an extensive class of combinatorial optimization problems widely existing in complex systems such as communication networks and unmanned systems. In SRA, the ability of a resource to complete a task is described by certain probability,and the objective is to maximize the reward by appropriately assigning available resources to different tasks. This paper is aimed at an important branch of SRA, that is, stochastic SRA(SSRA) for which the probability for resources to complete tasks is also uncertain. Firstly, a general SSRA model with multiple independent uncertain parameters(GSSRA-MIUP) is built to formulate the problem. Then,a scenario-based reformulation which can address multi-source uncertainties is proposed to facilitate the problem-solving process. Secondly, in view of the superiority of the differential evolution algorithm in real-valued optimization, a discrete version of this algorithm was originally proposed and further combined with a specialized local search to create an efficient hybrid optimizer. The hybrid algorithm is compared with the discrete differential evolution algorithm, a pure random sampling method, as well as a restart local search method. Experimental results show that the proposed hybrid optimizer has obvious advantages in solving GSSRA-MIUP problems.展开更多
文摘目的探讨儿童急性坏死性脑病(acute necrotizing encepha-lopathy of childhood,ANEC)的影像及临床特点,为早期识别ANEC提供参考依据。方法选取2010年9月~2020年12月本院ANEC患儿的临床及影像资料,分析本病的临床表现、实验室检查及MRI特点。结果21例患儿实验室检查血小板计数降低,转氨酶、乳酸脱氢酶、肌酸激酶同工酶不同程度升高,脑脊液细胞计数正常、蛋白定量明显升高,MRI显示病变呈双侧对称性分布,病灶为丘脑21例、基底节区15例、脑干14例、大脑白质14例、小脑8例、胼胝体2例和海马1例,病死率38.1%(8/21)。结论ANEC早期无特异性临床表现,病情进展快,病死率高,在冬季(12月~2月)对于存在高热、意识障碍并伴转氨酶、肌酸激酶同工酶升高的婴幼儿,应尽早完善MRI检查,以早期识别、诊断,为后续治疗、护理争取时间,提高存活率。
文摘目的探讨拉莫三嗪辅助治疗前庭性偏头痛的临床效果及对血清神经递质水平的影响。方法选择本院2018年4月-2019年7月接诊的前庭性偏头痛患者85例,通过随机数表法分为观察组45例和对照组40例,对照组给予盐酸氟桂利嗪胶囊治疗,观察组给予盐酸氟桂利嗪胶囊联合拉莫三嗪治疗,均连续治疗2个月,并比较2组临床疗效、眩晕情况、血清神经递质水平的变化及不良反应。结果治疗2个月后观察组总有效率明显高于对照组(91.11%vs 72.50%)(P<0.05);观察组眩晕发作次数、每次眩晕严重程度均明显低于对照组,眩晕持续时间明显短于对照组[(2.05±0.47) vs (2.94±0.61)次/月,(2.43±0.63) vs (3.59±0.88)分,(8.76±1.74) vs (10.09±2.11)h](P<0.05);观察组血清降钙素基因相关肽(CGRP)、P物质(SP)、内皮素-1(ET-1)水平明显低于对照组[(56.75±8.01) vs (66.42±9.65) ng/L,(162.30±15.42) vs (184.21±17.27) ng/L,(72.30±11.38) vs (88.27±13.47) pg/mL](P<0.05);2组不良反应总发生率无明显差异[13.33%vs 12.50%](P>0.05)。结论在氟桂利嗪基础上联合拉莫三嗪辅助治疗前庭性偏头痛的疗效显著,可有效改善血清神经递质表达水平,缓解临床症状,安全性好。
文摘目的系统评价连续性血液净化非计划下机的影响因素,为预防非计划下机提供参考依据。方法检索中国知网、万方数据库、中国生物医学文献数据库、中文科技期刊全文数据库、PubMed、Web of Science数据库中有关连续性血液净化非计划下机影响因素的文献,中文数据库检索时间为建库至2021年3月,英文数据库2016年3月至2021年3月。由两名研究者独立进行文献筛选、质量评价及资料提取,采用Stata 14.0软件进行Meta分析。结果共纳入文献11篇,累计连续性血液净化治疗3031例次,发生非计划下机1412例次,各影响因素合并OR值及95%CI分别为:治疗模式2.22(1.06-4.62)、血流速度0.91(0.76-1.09)、意识躁动4.54(2.33-8.86)、使用呼吸机2.67(1.63-4.38)、输入血制品及脂肪乳1.07(0.34-3.36)、一次性置管成功0.26(0.05-1.42)、置管部位(股静脉比颈静脉)2.24(0.83-6.02)。结论非计划下机受多因素影响,本研究显示治疗模式、意识躁动、使用呼吸机是非计划下机的危险因素;血流速度、输入血制品及脂肪乳、一次性置管成功、置管部位与非计划下机无相关性。
基金supported by the National Natural Science Foundation of China under Grant No.71361130011
文摘The stochastic resource allocation(SRA) problem is an extensive class of combinatorial optimization problems widely existing in complex systems such as communication networks and unmanned systems. In SRA, the ability of a resource to complete a task is described by certain probability,and the objective is to maximize the reward by appropriately assigning available resources to different tasks. This paper is aimed at an important branch of SRA, that is, stochastic SRA(SSRA) for which the probability for resources to complete tasks is also uncertain. Firstly, a general SSRA model with multiple independent uncertain parameters(GSSRA-MIUP) is built to formulate the problem. Then,a scenario-based reformulation which can address multi-source uncertainties is proposed to facilitate the problem-solving process. Secondly, in view of the superiority of the differential evolution algorithm in real-valued optimization, a discrete version of this algorithm was originally proposed and further combined with a specialized local search to create an efficient hybrid optimizer. The hybrid algorithm is compared with the discrete differential evolution algorithm, a pure random sampling method, as well as a restart local search method. Experimental results show that the proposed hybrid optimizer has obvious advantages in solving GSSRA-MIUP problems.
