大跨度上承式钢管混凝土拱桥受力性能分析

研究目的:为系统地掌握西北地区大温差、峡谷风、高震区共存的复杂建设条件下上承式钢管混凝土拱桥的力学性能,以一座净跨400 m的公路同类型拱桥为例,按照现行设计规范,采用统一模量法建立三维杆系有限元模型,对概率极限状态设计方法要求的静力性能、稳定性、动力特性、抗震性能的组合工况进行全面、系统地分析和计算,为同类型桥梁设计提供参考。研究结论:(1)温度效应大于汽车荷载效应,拱脚处横风效应突出;(2)双向偏压、偏拉组合受力为单弦杆控制设计状态,拱顶为桁式拱肋承载力的薄弱位置;(3)腹杆、横撑、平联等构件与弦杆构造匹配性较好时,承载力及疲劳性能等易满足受力需求;(4)温度、徐变预拱度比车道荷载大很多;(5)主拱圈在材料、几何、双重非线性下稳定性分别下降了5.5%、11.9%、17.1%;(6)振型相对密集、频率值较小,主振型为面外弯扭振动,具有多方向和多角度耦联性;(7)时程分析结果大于反应谱分析结果,但小于静力工况,拱桥抗震性能好;(8)上承式钢管混凝土拱桥在复杂建设条件下具有良好的受力性能。

寒区特长隧道斜井对隧道内温度影响实测研究

研究目的:寒区隧道内温度分布是保温设计和冻害防治的关键和前提,其影响因素可归纳为三类,即环境气象、工程结构以及交通因素。相较于环境气象和交通因素,目前针对工程因素,尤其特长隧道通风设施对隧道内温度分布影响的研究不足。结合青藏高原东南缘某高速公路特长隧道,系统开展了隧址区环境气象与不同建设阶段隧道内气温的空间分布与季节变化的连续观测,重点论述了通风斜井对隧道内温度环境的影响。研究结论:(1)隧道贯通前,洞内通风差,环境气温对隧道内温度的影响进深为300~400 m,隧道洞口段气温年平均值和振幅随进深增加呈指数形式增加和减小;(2)隧道开挖至斜井并与其连通后,在烟囱效应作用下,冷季时自进口至斜井形成稳定的单向风,洞内气温基本呈线性分布,梯度约为0.5℃/100 m;(3)隧道贯通后,冷季时斜井烟囱效应引发隧道内形成稳定的自进口、出口至斜井的双向通风,洞内温度呈现基本以斜井为中心的对称分布,全隧道范围内出现显著负温;(4)通风斜井对隧道内温度分布规律及负温段长度均有显著的影响,在寒区隧道保温设防和冻害防治中应予以考虑。

氧化石墨烯/罗丹明6G改性滤纸的制备及性能

利用氧化石墨烯(GO)和罗丹明6G-聚乙烯亚胺(R6G-PEI)对滤纸(FP)进行物理改性,制备了纸基传感器FP/GO/R6G-PEI。利用扫描电子显微镜、X-射线衍射仪、伺服材料多功能高低温控制试验机、紫外光谱仪和荧光光谱仪等,对FP/GO/R6G-PEI的形貌、力学性能和传感性能进行表征。结果表明,与FP、FP/GO相比,FP/GO/R6G-PEI的表面平滑度提高,透气度降低,力学性能增大。将FP/GO/R6G-PEI浸泡于Fe^(3+)溶液中时,观察到FP/GO/R6G-PEI变为淡粉红色,且荧光强度显著增强,可实现FP/GO/R6G-PEI对水中的Fe^(3+)肉眼可见和荧光检测。理想识别单元Structure 3与Fe^(3+)的能级差(0.53 eV)小于Structure 3的能极差(3.12 eV),说明Structure 3与Fe^(3+)的螯合体系更稳定。

Experimental Study on Wire Melting Control Ability of Twin-Body Plasma Arc

The twin-body plasma arc has the decoupling control ability of heat transfer and mass transfer,which is beneficial to shape and property control in wire arc additive manufacturing.In this paper,with the wire feeding speed as a characteristic quantity,the wire melting control ability of twin-body plasma arc was studied by adjusting the current separation ratio(under the condition of a constant total current),the wire current/main current and the position of the wire in the arc axial direction.The results showed that under the premise that the total current remains unchanged(100 A),as the current separation ratio increased,the middle and minimum melting amounts increased approximately synchronously under the effect of anode effect power,the first melting mass range remained constant;the maximum melting amount increased twice as fast as the middle melting amount under the effect of the wire feeding speed,and the second melting mass range was expanded.When the wire current increased,the anode effect power and the plasma arc power were both factors causing the increase in the wire melting amount;however,when the main current increased,the plasma arc power was the only factor causing the increase in the wire melting amount.The average wire melting increment caused by the anode effect power was approximately 2.7 times that caused by the plasma arc power.The minimum melting amount was not affected by the wire-torch distance under any current separation ratio tested.When the current separation ratio increased and reached a threshold,the middle melting amount remained constant with increasing wire-torch distance.When the current separation ratio continued to increase and reached the next threshold,the maximum melting amount remained constant with the increasing wire-torch distance.The effect of the wire-torch distance on the wire melting amount reduced with the increase in the current separation ratio.Through this study,the decoupling mechanism and ability of this innovative arc heat source is more clearly.

胃肠间质瘤术前靶向治疗后的病理学评估与影像学评估的一致性分析

目的:探讨Choi标准及病理学效应对胃肠间质瘤(gastrointestinal stromal tumor, GIST)术前靶向治疗后疗效及预后的评估价值,并观察两者的一致性。方法:回顾性分析于昆明医科大学第三附属医院收治37例术前伊马替尼(imatinib,IM)靶向治疗GIST患者的临床病理资料,Kaplan-Meier法和Log-rank检验对Choi标准及病理学效应进行生存分析,Spearman等级相关及Kappa检验分析Choi标准与病理学效应的一致性。结果:37例患者术前中位治疗时间为10(2~36)个月。Choi标准评估无完全缓解(complete response,CR)病例,部分缓解(partial response,PR)26例,疾病稳定(stable disease,SD)5例,疾病进展(progressive disease,PD)6例;Choi标准疗效有效组(CR+PR)与无效组(SD+PD)之间总生存期的差异具有统计学意义(P<0.01)。病理学效应评估完全效应1例,高度效应11例,部分效应18例,零级效应7例;病理效应有效组(完全效应+高度效应+部分效应)与无效组(零级效应)之间总生存期的差异具有统计学意义(P<0.01)。Choi标准与病理学效应有相关性(r=0.592,P<0.01)及中度一致性(κappa=0.566)。结论:Choi标准与病理学效应有中等程度的相关性及一致性,两者均可作为胃肠间质瘤术前靶向治疗疗效评估及预后判断的参考指标,联合应用两者评估具有更高的临床应用价值。

1344吡啶羧酸配体构筑的Cu(Ⅱ)-MOFs及其染料吸附降解性能

为探究不同反应条件对MOFs微观结构和宏观性能的影响,在不同反应条件下,以硫酸铜(CuSO_(4)·5H_(2)O)和6-(吡啶-3′-基)间苯二甲酸(H_(2)L)为材料,制备了2种金属有机框架材料(MOFs){[Cu_(2)(L)_(2)·C _(2) H _(3) N]}n(1)和{[Cu(HL)_(2)]}n(2),并对合成的金属有机框架材料1和2进行了结构分析、TGA和FTIR表征以及对染料的吸附性能研究。单晶衍射数据分析表明:配合物1和2都属单斜晶系,P 21/c空间群。配合物1是一种基于双核轮桨次级构筑单元[Cu_(2)(COO)_(4)]构筑的三维紧密堆积化合物,配合物2由于配体部分质子化,结构中存在氢键[O_(3)—H…O_(4)],将二维层状网络结构连接成三维结构。配合物1是rtl拓扑类型的网络结构,拓扑符号为(42.610.83);配合物2是sql拓扑类型的网络结构,拓扑符号为(4^(4).6^(2))。2种配合物在相同时间间隔下对不同染料降解性能表明配合物2对水溶液中的孔雀石绿具有一定的化学吸附降解能力。

罗丹明6G-聚乙烯亚胺改性纤维素纳米晶的制备及性能

利用罗丹明6G-聚乙烯亚胺(R6G-PEI)对纤维素纳米晶(CNC)化学改性,制备了传感器CNC-PEI-R6G。利用FT-IR、XRD、XPS、UV-vis和PL等分析手段对CNC-PEI-R6G的组成结构和检测性能进行表征。研究表明,氧化时间的长短对双醛纤维素纳米晶(D-CNC)中醛基的含量影响很大。加入Fe^(3+)时,观察到CNC-PEI-R6G溶液变为粉红色,且在566nm处的荧光强度显著增强,实现对水介质中Fe^(3+)的肉眼检测和荧光选择性识别,检测限为0.03mg/kg。此外,CNC-PEI-R6G还可用于准确识别自来水和泳池水等实际水样中的Fe^(3+)。

Analysis on the Effect of Yiqi Huoxue Decoction Combined with Neuromuscular Electrical Stimulation in Improving ICU-Acquired Debility in Mechanically Ventilated Patients

Objective:To investigate the effect of Yiqi Huoxue decoction combined with neuromuscular electrical stimulation on improving intensive care unit(ICU)acquired debility in mechanically ventilated patients.Methods:50 patients who were admitted to the ICU and received mechanical ventilation treatment in our hospital from June 2022 to June 2023 and were complicated with ICU-acquired neurasthenia were selected,and randomly grouped using the randomized envelope method into two groups:control group with 25 patients who received neuromuscular electrical stimulation alone;observation group with 25 patients who received the traditional Chinese medicine Yiqi Huoxue decoction.Comparison indexes:treatment efficiency,degree of emotional recovery(APACHEⅡscore),muscle strength status(MRC score),motor status(FAC rating),and self-care ability(BI index score).Results:The treatment efficiency of patients in the observation group patients was higher as compared to those in the control group(P<0.05).There was no significant difference in the comparison of the results of the scores(ratings)of each index between the two groups before treatment(P>0.05).After the treatment,the APACHEⅡscores of patients in the observation group were significantly lower as compared to those in the control group,while the MRC scores,FAC ratings,and BI index scores were higher in the observation group than those of the control group patients(P<0.05).Conclusion:The combined application of Yiqi Huoxue decoction and neuromuscular electrical stimulation in the treatment of patients with ICU-acquired neurasthenia complicated by mechanical ventilation significantly enhanced the clinical efficacy,the patient’s muscle strength,motor status,and ability of self-care.Hence,it has high application value and is worthy to be popularized.

改进型简支组合箱梁破坏机理及设计问题研究

改进型组合箱梁是以平钢板置换传统波纹钢腹板组合箱梁下翼板(RC板)而建造的新型钢混结构。为完善该类结构设计理论,其更为精准的力学分析尤为必要。对改进型组合箱梁悬臂板和上下翼板设置了2个不同的剪滞纵向位移差函数,同时引入剪滞翘曲应力和弯矩自平衡条件,进而建立该类组合箱梁的弹性控制微分方程,基于此实现改进型组合箱梁力学性能弹性阶段的精细化分析,其破坏模式则主要以试验研究为主。研究表明:简支改进型组合箱梁,其钢底板正应力约为顶板的20倍,而钢底板与顶板的设计强度之比为13.6,因此,竖向弯曲状态该类结构钢底板将会发生屈服破坏;由于剪力滞效应影响,钢底板与腹板相交处,钢底板首先发生屈服,继而随着竖向荷载增加,其屈服点逐渐向钢底板横向中心延伸;改进型组合箱梁破坏形式,钢底板首先屈服,且其挠度快速增加,继而上翼板(RC板)压溃;基于改进型组合箱梁破坏特点,通过施加预应力筋,并合理调整箱梁材料和断面几何参数,进而实现顶板和钢底板的协调破坏。因而,本文方法是对改进型组合箱梁力学性能演化规律的探索,其分析成果将对该类结构设计具有指导作用。

聚乙烯醇纤维钢筋复合梁抗弯性能试验研究

掺入聚乙烯醇纤维(简称“PVA纤维”)的钢筋混凝土梁具有优良的抵抗变形能力和抗裂性能,在工程结构中具有良好的应用前景。为研究PVA纤维的掺入对PVA纤维钢筋复合梁(简称“PRC梁”)抗弯性能的影响,进行了4根PVA纤维体积掺量不同的PRC梁的静态三点弯曲加载试验。结果表明:PVA纤维的掺入并没有改变PRC梁的破坏形态,且破坏过程相似;但是掺入PVA纤维极大增强了PRC梁的抗裂性,延缓了裂缝的出现。相比于普通RC梁,0.75%(体积分数)掺量下的PRC梁开裂荷载提高了2.1倍;同时,掺入PVA纤维能够小幅增加PRC梁的抗弯承载力,在加载过程中,PVA纤维混凝土与钢筋能够更好地协同工作,从而增强了PRC梁的持荷变形能力;荷载位移曲线的积分面积表明(利用Origin曲线积分发现)PRC梁在加载过程中吸收的能量更多,因此,掺入PVA纤维能够有效增强PRC梁的延性。

QoS-Aware Offloading Based on Communication-Computation Resource Coordination for 6G Edge Intelligence

Driven by the demands of diverse artificial intelligence(AI)-enabled application,Mobile Edge Computing(MEC)is considered one of the key technologies for 6G edge intelligence.In this paper,we consider a serial task model and design a quality of service(QoS)-aware task offloading via communication-computation resource coordination for multi-user MEC systems,which can mitigate the I/O interference brought by resource reuse among virtual machines.Then we construct the system utility measuring QoS based on application latency and user devices’energy consumption.We also propose a heuristic offloading algorithm to maximize the system utility function with the constraints of task priority and I/O interference.Simulation results demonstrate the proposed algorithm’s significant advantages in terms of task completion time,terminal energy consumption and system resource utilization.

考虑温度影响的干摩擦接触分子动力学研究

基于多尺度方法对干摩擦行为进行预测已成为当前研究热点。对于航空发动机等高温机械系统,温度对干摩擦行为影响至关重要。针对高温影响下微动界面摩擦行为开展分子动力学建模与分析,研究不同温度下微凸体的切向碰撞过程;考虑温度的升高使摩擦界面微凸体黏着作用增强,提出不同于赫兹接触理论预测的真实面积计算方法;基于所建的分子动力学模型和G-W接触模型,研究不同温度下接触面的摩擦系数,与实验测量的摩擦系数结果吻合,验证所提方法的正确性。对于在高温环境下接触、摩擦及微动等界面力学问题的研究提供了可借鉴的方法,同时为高温旋转机械动力学多尺度方法提供了可参考的解决手段。

Inhibition of H_(2)O_(2)-induced apoptosis of GC2-spg cells by functionalized selenium nanoparticles with lentinan through ROSmediated ERK/p53 signaling pathways

AH_(2)O_(2)-induced oxidative stress injury cell model was established to investigate the antioxidant effect of nanoselenium on mouse spermatocyte lines and the regulation mechanism of the expression level and activity of seleniumcontaining antioxidant enzymes induced by oxidative stress.A safe and effective nano-drug system of functionalized selenium-containing nanoparticles(SeNPs)was developed with lentinan(LNT)(SeNPs@LNT).Mice spermatocyte line GC2-spg cells were treated with SeNPs@LNT(1,2,4,8,16,32μM)for 24-72 h to evaluate the cytotoxicity of selenium.GC2-spg cells were randomly divided into the following groups:control,hydrogen peroxide(H_(2)O_(2)),SeNPs@LNT,and H_(2)O_(2)+SeNPs@LNT groups.H_(2)O_(2)+SeNPs@LNT group was pretreated with SeNPs@LNT 4μM for 12 h,followed by H_(2)O_(2)600μM for 8 h.The cell viability decreased in the H_(2)O_(2) group and increased significantly in the SeNPs@LNT group.Compared with the H_(2)O_(2) group,the SeNPs@LNT+H_(2)O_(2) group exhibited obvious red fluorescence,indicating a higher level of mitochondrial membrane potential.The content of intracellular reactive oxygen species(ROS)in the SeNPs@LNT group reduced significantly,and the intensity of green fluorescence in the SeNPs@LNT+H_(2)O_(2) group decreased significantly compared with the H_(2)O_(2) group,indicating the inhibitory effect of SeNPs@LNT on the generation of ROS-induced oxidative stress.The activity of GPx and SOD increased significantly in the SeNPs@LNT group.The expression of p53 decreased significantly under the intervention of nano-selenium,and GPx1 expression increased.In the oxidative stress group,the expressions of DNA damage-related proteins and apoptosis-related proteins were higher than those in other groups.Thus,SeNPs@LNT can promote GC2-spg cell proliferation,improve GPx and SOD activities,remove intracellular ROS,and reduce mitochondrial damage and functional abnormalities caused by oxidative stress by regulating the ERK and p53 protein levels.SeNPs@LNT has good biological activity and antioxidant effect,which can be used to protect the male reproductive system from oxidative stress.

复杂纵隔肿瘤的微创治疗

复杂纵隔肿瘤是指由于位置深、体积巨大、侵犯周围重要结构或存在其他特殊特征,使得手术治疗具有较高难度和复杂性的纵隔肿瘤。复杂纵隔肿瘤最常见的类型有胸腺肿瘤、神经源性肿瘤、畸胎瘤、生殖细胞肿瘤、肉瘤、淋巴瘤和肺癌转移性纵隔淋巴结肿瘤等。良恶性肿瘤都会形成复杂的纵隔肿瘤。

乙烯聚合Ziegler-Natta催化剂在聚乙烯管材专用料的应用

JCES催化剂与装置常用催化剂(Ref催化剂)进行小试对比研究,表明JCES催化剂具有良好的活性、优异的氢调性能及共聚性能。采用JCES催化剂用于CX聚合工艺高密度聚乙烯装置,生产聚乙烯管材专用料(牌号为L7100M)。生产结果表明,由Ref催化剂切换至JCES催化剂生产过程中进料量平稳无明显波动,参数调整稳定。JCES催化剂的活性及聚合物堆密度与Ref催化剂基本一致,JCES催化剂的氢调敏感性及共聚性能优于Ref催化剂,由JCES催化剂生产的聚合物的分布更加集中,细粉含量比Ref催化剂少。JCES催化剂生产的L7100M产品质量属于优级品,表明JCES催化剂适用于CX工艺生产聚乙烯管材专用料。

隧道跟随式照明智能调光系统在高速公路的应用

高速公路隧道照明调光节能技术的发展,能有效实现隧道照明按需调节,减少电能浪费,降低运营成本。本文介绍了隧道跟随式照明智能调光系统在广东云茂高速公路的具体应用,分析其工作机理和实际节能效果,对推动智慧高速公路隧道照明智能化具有现实借鉴意义。

Discovery of Kaempferol,a Novel ADAM10 Inhibitor,as a Potential Treatment for Staphylococcus aureus Infection

Host-directed therapy(HDT)is an emerging novel approach for treating multidrug-resistant Staphylococcus aureus(S.aureus)infection.Functioning as the indispensable specific cellular receptor for a-toxin(Hla),a-disintegrin and metalloproteinase 10(ADAM10)is exploited to accelerate S.aureus infection through diverse mechanisms.The extraordinary contribution of ADAM10 to S.aureus pathogenesis renders it an attractive HDT target for combating S.aureus infection.Our study is the first to demonstrate the indispensable role of ADAM10 in S.aureus-induced necroptosis,and it enhances our knowledge of the role of ADAM10 in S.aureus infection.Using a fluorogenic substrate assay,we further identified kaempferol as a potent ADAM10 inhibitor that effectively protected mice from S.aureus infection by suppressing Hla-mediated barrier disruption and necroptosis.Collectively,our work presents a novel hostdirected therapeutic strategy for using the promising candidate kaempferol to treat S.aureus infection and other diseases relevant to the disordered upregulation of ADAM10.

Inhibition of H_(2)O_(2)-induced TM3 cell apoptosis by oxidative stress by lentinan functionalized selenium nanoparticles through JAK2/STAT-3 and P53 pathways

Background:Nano-selenium has been widely used in antiviral and anticancer therapy,and has the advantages of good targeting and low toxicity.For the first time,we combined male reproduction with nano-selenium to investigate its antioxidant effect.This study investigated the protective effect of lentinan functionalized selenium nanoparticles on oxidative stress injury of the hydrogen peroxide(H_(2)O_(2))-induced Leydig cell line,TM3.Methods:The suitable concentration of nano-selenium treatment to promote cell proliferation was also discussed.The concentration of 4μM could significantly promote the growth of TM3 cells.Oxidative stress damage was caused using an 800μM concentration of hydrogen peroxide.The cells were divided into four groups:normal control group,oxidative stress treatment group,H_(2)O_(2)+SeNPs@LNT group,and SeNPs@LNT group.The H_(2)O_(2)+SeNPs@LNT group was pretreated with 4μM of SeNPs@LNT for 12 h,followed by 800μM of H_(2)O_(2)for 8 h.Results:Nano-selenium could significantly promote the proliferation and viability of TM3 cells.SeNPs@LNT treatment increased the level of mitochondrial membrane potential in normal cells and slowed down the decline in mitochondrial membrane potential level caused by oxidative stress injury.In addition,the increase in reactive oxygen species caused by oxidative stress was inhibited by SeNPs@LNT treatment.The apoptosis of TM3 cells was detected,and SeNPs@LNT alleviated the necrosis and apoptosis of TM3 cells induced by H_(2)O_(2).Nano-selenium plays a protective role against oxidative H_(2)O_(2)-induced stress injury in TM3 cells through the changes in the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway and P53 pathway,and the expression levels of other related proteins,protein kinase B(AKT)and C3.Conclusion:SeNPs@LNT exhibited good biological activity and antioxidant effect and can thus be used to protect the male reproductive system from oxidative stress.

半导体激光穴位照射联合川芎嗪治疗膝骨关节炎的临床研究

目的探讨半导体激光穴位照射联合川芎嗪治疗膝骨关节炎的临床疗效。方法选取符合入组标准的膝骨关节炎患者72例,使用SPSS19.0的随机数字发生器分为3组,分别是半导体激光穴位注射组(A组)、川芎嗪关节内注射组(B组)和半导体激光穴位照射联合川芎嗪关节内注射组(C组),治疗周期为4周。采用Lysholm评分标准和视觉模拟评分量表(VAS)对患者进行膝关节功能和疼痛的评估,并由专业的康复治疗师评估患者治疗后的膝关节活动度(ROM)和疗效缓解情况;采用医院焦虑抑郁量表(HAD)和匹茨堡睡眠质量指数量表(PSQI)评估患者的情绪和睡眠质量;采用股骨头前后位和侧位X射线测量各患者的影像学角度。结果 3组患者的总有效率分别是83.3%、73.1%和93.1%。所有患者治疗后VAS评分、ROM和膝关节功能评分均较治疗前显著改善。A、B两组治疗后VAS评分、ROM、膝关节功能评分、PSQI、HAD-A和HAD-B评分差异无统计学意义(P>0.05)。与A组和B组比较,C组治疗后的VAS评分、膝关节功能评分、PSQI、HAD-A和HAD-B评分降低,ROM角度增加,差异有统计学意义(P <0.05)。A组和B组影像学检测的各个角度参数差异无统计学意义(P>0.05),C组影像学检测的各个角度参数较A组和B组减小,差异有统计学意义(P<0.05)。3组患者治疗后股骨长度、局部肿胀疼痛、照射部位损伤和过敏反应发生率差异无统计学意义(P>0.05)。结论半导体激光穴位照射联合川芎嗪关节内注射能有效改善膝骨关节炎患者的疼痛,促进膝关节功能的恢复,提高患者睡眠质量和情绪。

单箱双室组合箱形梁桥静力学特性的研究

为了准确分析单箱双室波纹钢腹板组合箱梁的竖向弯曲力学性能,考虑了组合箱梁的剪力滞、剪切变形、腹板褶皱效应以及剪滞翘曲应力自平衡等因素,设置了3个剪滞纵向翘曲位移差函数,进而基于能量变分法建立了组合箱梁的弹性控制微分方程和自然边界条件。研究表明,褶皱效应对组合箱梁力学性能具有一定影响,且集中荷载下组合箱梁的褶皱效应更为突出;简支边界条件下,组合箱梁剪力滞效应明显,特别是集中荷载组合箱梁的剪力滞效应趋强;本文方法具有一定的理论和工程实用价值,且对该类结构设计具有重要的指导作用。