OBJECTIVE:To assess the acute organ toxicity of Strychnos nux-vomica with zebrafish model visually.METHODS:To assess acute toxicity,we initially determined the lethal concentration after Strychnos nux-vomica treatment...OBJECTIVE:To assess the acute organ toxicity of Strychnos nux-vomica with zebrafish model visually.METHODS:To assess acute toxicity,we initially determined the lethal concentration after Strychnos nux-vomica treatment for 24 h.Zebrafish was treated with five concentrations Strychnos nux-≦vo LC10 for 24 h,and the effects ofmica on morphology,function of heart,central nervous system,liver,kidney and organ-specific cell death were assessed.Next,we assessed the reversibility of toxic effect.RESULTS:Strychnos nux-vomica has an effect on the different organs of zebrafish,including heart,central nervous system,liver,and kidney,and cadiotoxicity induced by Strychnos nux-vomica was reversible to some extent.CONCLUSION:Zebrafish model is suitable for confirming the toxic target organs for Chinese traditional medicine.展开更多
In this paper, the problem of quadratic stabilization of multi-input multi-output switched nonlinear systems under an arbitrary switching law is investigated.When switched nonlinear systems have uniform normal form an...In this paper, the problem of quadratic stabilization of multi-input multi-output switched nonlinear systems under an arbitrary switching law is investigated.When switched nonlinear systems have uniform normal form and the zero dynamics of uniform normal form is asymptotically stable under an arbitrary switching law, state feedbacks are designed and a common quadratic Lyapunov function of all the closed-loop subsystems is constructed to realize quadratic stabilizability of the class of switched nonlinear systems under an arbitrary switching law.The results of this paper are also applied to switched linear systems.展开更多
基金Supported by the Scientific Research And Postgraduate Education Joint Project(Key Technology Research and Application of Safety Evaluation for Toxic Chinese Medicinal Materials on the Basis of the Characteristics of Chemical Composition and Zebrafish,No.2050205)
文摘OBJECTIVE:To assess the acute organ toxicity of Strychnos nux-vomica with zebrafish model visually.METHODS:To assess acute toxicity,we initially determined the lethal concentration after Strychnos nux-vomica treatment for 24 h.Zebrafish was treated with five concentrations Strychnos nux-≦vo LC10 for 24 h,and the effects ofmica on morphology,function of heart,central nervous system,liver,kidney and organ-specific cell death were assessed.Next,we assessed the reversibility of toxic effect.RESULTS:Strychnos nux-vomica has an effect on the different organs of zebrafish,including heart,central nervous system,liver,and kidney,and cadiotoxicity induced by Strychnos nux-vomica was reversible to some extent.CONCLUSION:Zebrafish model is suitable for confirming the toxic target organs for Chinese traditional medicine.
基金Supported partially by the National Natural Science Foundation of China (Grant No 50525721)
文摘In this paper, the problem of quadratic stabilization of multi-input multi-output switched nonlinear systems under an arbitrary switching law is investigated.When switched nonlinear systems have uniform normal form and the zero dynamics of uniform normal form is asymptotically stable under an arbitrary switching law, state feedbacks are designed and a common quadratic Lyapunov function of all the closed-loop subsystems is constructed to realize quadratic stabilizability of the class of switched nonlinear systems under an arbitrary switching law.The results of this paper are also applied to switched linear systems.
